Effect of gonadectomy and hormones on sex differences in ketoprofen enantiomer glucuronidation and renal excretion of formed glucuronides in the rat

Pharmaceutical Research

Volumn 21, Issue 6, 2004, Pages 989-995

  Palylyk Colwell, Eugenia L ^a   Jamali, Fakhreddin ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

glucuronidation; gonadectomy; ketoprofen; nonsteroidal anti inflammatory drug; sex differences

Indexed keywords

ESTRADIOL; GLUCURONIDE; KETOPROFEN; SEX HORMONE; TESTOSTERONE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG EXCRETION; DRUG GLUCURONIDATION; ENANTIOMER; FEMALE; GONADECTOMY; HORMONE ACTION; KIDNEY METABOLISM; LIVER METABOLISM; MALE; MICROSOME; NONHUMAN; PRIORITY JOURNAL; RAT; SEX DIFFERENCE; URINARY EXCRETION;

ANIMALS; CANADA; ESTRADIOL; FEMALE; FORECASTING; GLUCURONATES; GONADAL STEROID HORMONES; KETOPROFEN; KIDNEY; MALE; MICROSOMES, LIVER; ORCHIECTOMY; OVARIECTOMY; RATS; RATS, SPRAGUE-DAWLEY; SEX CHARACTERISTICS; STEREOISOMERISM; TESTOSTERONE;

EID: 3042721900     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/B:PHAM.0000029288.48673.c2     Document Type: Article

References (32)

1. B. Meibohm, I. Beierle, and H. Derendorf. How important are sex differences in pharmacokinetics? Clin. Pharmacokinet. 41:329-342 (2002).
2. J. B. Schwartz. The influence of sex on pharmacokinetics. Clin. Pharmacokinet. 42:107-121 (2003).
3. P. Bonate. Sex-related differences in xenobiotic metabolism. J. Clin. Pharmacol. 31:684-690 (1991).
4. G. G. Gibson and P. Skett. Introduction to Drug Metabolism, 3rd ed, Nelson Thornes, Cheltenham, UK, 2001.
5. L. Salphati and L. Z. Benet. Modulation of P-glycoprotein expression by cytochrome P450 3A inducers in male and female rat livers. Biochem. Pharmacol. 55:387-395 (1998).
6. N. Kudo, M. Katakura, Y. Sato, and Y. Kawashima. Sex hormone-regulated renal transport of perfluorooctanoic acid. Chem. Biol. Interact. 139:301-316 (2002).
7. G. J. Mulder. Sex differences in drug conjugation and their consequences for drug toxicity. Sulfation, glucuronidation and glutathione conjugation. Chem. Biol. Interact. 57:1-15 (1986).
8. P. Skett. P. Biochemical basis of sex differences in drug metabolism. Pharmac. Ther. 38:269-304 (1988).
9. E. L. Palylyk and F. Jamali. Influence of sex on the stereoselective probenecid-ketoprofen interaction in the rat. J. Pharm. Sci. 83:1184-1185 (1994).
10. G. F. Rush, J. F. Newton, and J. B. Hook. Sex differences in the excretion of glucuronide conjugates: the role of intrarenal glucuronidation. J. Pharmacol. Exp. Ther. 227:658-662 (1983).
11. R. S. Chhabra and J. R. Fouts. Sex differences in the metabolism of xenobiotics by extrahepatic tissue in rats. Drug Metabol. Disp. 2:375-379 (1974).
12. D. L. Graham and P. Skett. Endocrine regulation of the metabolism of 1-napthol in the rat. J. Pharmacol. Exp. Ther. 242:344-348 (1987).
13. P. Skett, A. Mode, J. Rafter, L. Sahlin, and J. A. Gustafsson. The effects of gonadectomy and hypophysectomy on the metabolism of imipramine and lidocaine by the liver of male and female rats. Biochem. Pharmacol. 29:2759-2762 (1980).
14. Y. Tanaka, Y. Kadoh, and H. Ishikawa. Effects of hypophysectomy and testosterone treatment on the urinary excretion of zenarestat in rats. Xenobiotica 22:51-55 (1992).
15. P. Bertagni, P. C. Hirom, P. Millburn, F. O. Osiyemi, R. L. Smith, H. B. Turbert, and R. T. Williams. Sex and species differences in the biliary excretion of tartrazine and lissamine fast yellow in the rat, guinea-pig and rabbit. The influence of sex hormones on tartrazine excretion in the rat. J. Pharm. Pharmac. 24:620-624 (1972).
16. R. C. Blantz, O. W. Peterson, E. R. Blantz, and C. B. Wilson. Sexual differences in glomerular ultrafiltration: effect of androgen administration in ovarectomized rats. Endocrinology 22:767-773 (1988).
17. S. V. Gothoskar and E. K. Weisburger. Protection by testosterone propionate against the nephrotoxicity of 2-aminoanthraquinone in Fischer rats. Medical Biol. 58:281-284 (1980).
18. P. Skett. Hormonal regulation and sex differences of xenobiotic metabolism. Prog. Drug Metabol. 10:85-139 (1987).
19. H. B. Waynforth. Experimental and Surgical Technique in the Rat, Academic Press, London, 1980.
20. O. H. Lowry, N. J. Rosebrough, A. I. Farr, and R. J. Randall. Protein measurement with the folin phenol reagent. J. Biol. chem. 193:265-275 (1951).
21. E. L. Palylyk and F. Jamali. Simultaneous determination of ketoprofen enantiomers and probenecid in plasma and urine by high-performance liquid chromatography. J. Chromatogr. 568:187-196 (1991).
22. Y. Tanaka, Y. Deguchi, I. Ishi, and T. Terai. Sex differences in excretion of zenarestat in rat. Xenobiotica 21:1119-1125 (1991).
23. E.L. Palylyk and F. Jamali. Gender related differences in the pharmacokinetics of ketoprofen enantiomers in the rat. Pharm. Res. 9, 10:S-263 (1992).
24. E. A. Iatsimirskaia, M. L. Gregory, K. L. Anderes, R. Castillo, K. E. Milgram, D. R. Luthin, V. P. Pathak, L. C. Christie, H. Vazir, M. B. Anderson, and J. M. May. Effect of testosterone suppression on the pharmacokinetics of a potent gnRH receptor antagonist. Pharm. Res. 19:202-208 (2002).
25. R. T. Foster and F. Jamali. F. Stereoselective pharmacokinetics of ketoprofen in the rat: influence of route of administration. Drug Metabol. Disp. 16:623-626 (1988).
26. M. Reis, J. Lundmark, and F. Bengtsson. Therapeutic drug monitoring of racemic citalopram: a 5-year experience in Sweden, 1992-1997. Ther. Drug Monit. 25:183-191 (2003).
27. T. Walle, U. K. Walle, T. D. Cowart, and E. C. Conradi. Pathway-selective sex differences in the metabolic clearance of propranolol in human subjects. Clin. Pharmacol. Ther. 46:257-263 (1989).
28. M. E. Krecic-Shepard, C. R. Barnas, J. Slimko, M. P. Jones, and J. B. Schwartz. Sex-specific effects on verapamil pharmacokinetics and pharmacodynamics in humans. J. Clin. Pharmacol. 40:219-230 (2000).
29. C. J. Richardson, K. L. Blocka, S. G. Ross, and R. K. Verbeeck. Effects of age and sex on piroxicam disposition. Clin. Pharmacol. Ther. 37:13-18 (1985).
30. R. W. Gear, C. Miaskowski, N. C. Gordon, S. M. Paul, P. H. Heller, and J. D. Levine. Kappa-opioids produce significantly greater analgesia in women than in men. Nat. Med. 2:1248-1250 (1996).
31. R. B. Fillingim. Sex differences in analgesic responses: evidence from experimental pain models. Eur. J. Anaesthesiol. Suppl. 26:16-24 (2002).
32. F. Jamali and D. R. Brocks. Clinical pharmacokinetics of ketoprofen and its enantiomers. Clin. Pharmacokinet. 19:197-217 (1990).