Anti-inflammatory activity of Leontopodium alpinum and its constituents

Planta Medica

Volumn 70, Issue 6, 2004, Pages 502-508

  Dobner, Michael J ^a   Sosa, Silvio ^b   Schwaiger, Stefan ^a   Altinier, Gianmario ^b   Della Loggia, Roberto ^b   Kaneider, Nicole C ^a   Stuppner, Hermann ^a,c  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^b UNIVERSITY OF TRIESTE   (Italy)

^c UNIVERSITY OF INNSBRUCK   (Austria)

Author keywords

Anti inflammatory activity; Asteraceae; Chemotaxis; Leontopodium alpinum; Mouse ear oedema

Indexed keywords

COUMARIN DERIVATIVE; CROTON OIL; DICHLOROMETHANE; FATTY ACID; LENTOPODIUM ALPINUM EXTRACT; LIGNAN DERIVATIVE; METHANOL; PLANT EXTRACT; SESQUITERPENE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DERMATITIS; EAR; EDEMA; INFLAMMATION; INFLAMMATORY CELL; LENTOPODIUM ALPINUM; MALE; MEDICINAL PLANT; MOUSE; NEUTROPHIL; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PLANT ROOT;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ASTERACEAE; CELL MIGRATION INHIBITION; CROTON OIL; DOSE-RESPONSE RELATIONSHIP, DRUG; EDEMA; MALE; MICE; MICE, INBRED STRAINS; PHYTOTHERAPY; PLANT COMPONENTS, AERIAL; PLANT EXTRACTS; PLANT ROOTS;

ANIMALIA; ASTERACEAE; CROTON; LEONTOPODIUM; LEONTOPODIUM ALPINUM;

EID: 3042719111     PISSN: 00320943     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2004-827148     Document Type: Article

References (22)

1. Dobner MJ, Schwaiger S, Jenewein IH, Stuppner H. Antibacterial activity of Leontopodium alpinum (Edelweiss). J Ethnopharm 2003; 89: 301-3
2. Stuppner H, Ellmerer EP, Ongania KH, Dobner M. Bisabolane derivatives from Leontopodium alpinum. Helv Chim Acta 2002; 85: 2982-9
3. Dobner MJ, Ellmerer-Müller EP, Schwaiger S, Batsugh O, Narantuya S, Stütz M, Stuppner H. New lignan, benzofuran and sesquiterpene derivatives from the roots of Leontopodium alpinum and L. leontopodioides. Helv Chim Acta 2003; 86: 733-8
4. Li LY, Ye JM, Yin H, Zhu YM, Tian JM, Gao F. Effect of Leontopodium leontopodioides (Willd.) Beauv, on inflammation induced by animal reversed passive arthus. Chung Kuo Chung Yao Tsa Chih 1994; 19: 174-6
5. Tubaro A, Dri P, Delbello G, Zilli C, Della Loggia R. The Croton oil ear test revisited. Agents Actions 1985; 17: 346-9
6. Bradley PP, Priebat DA, Christensen RD, Rothstein G. Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker. J Invest Dermatol 1982; 78: 206-9
7. Andrews PC, Krinsky NI. The reductive cleavage of myeloperoxidase in half, producing enzymatically active hemi-myeloperoxidase. J Biol Chem 1981; 256: 4211-8
8. Kaneider NC, Reinisch CM, Dunzendorfer S, Meierhofer C, Djanani A, Wiedermann CJ. Induction of apoptosis and inhibition of migration of inflammatory and vascular wall cells by cerivastatin. Atherosclerosis 2001; 158: 23-33
9. Campling BG, Pym J, Galbraith P, Cole S. Use of the MTT assay for rapid determination of chemosensitivity of human leukemic blast cells. Leukemia Res 1988; 12: 823-31
10. Haberstock H, Marotti T, Banfic H, Neutrophil signal transduction in met-enkephalin modulated superoxide anion release. Neuropeptides 1996; 30: 193-201
11. Zidorn C, Dirsch VM, Rüngeler P, Sosa S, Della Loggia R, Merfort I, Pahl HL, Vollmar AM, Stuppner H. Anti-inflammatory activities of hypocretenolides from Leontodon hispidus. Planta Med 1999; 65: 704-8
12. Zitterl-Eglseer K, Sosa S, Jurenitsch J, Schubert-Zsilavecz M, Delia Loggia R, Tubaro A, Bertoldi M, Franz C. Anti-edematous activities of the main triterpendiol esters of marigold (Calendula officinalis L.). J Ethnopharm 1997; 57: 139-44
13. Baricevic D, Sosa S, Della Loggia R, Tubaro A, Simonovska B, Krasna A, Zupancic A. Topical anti-inflammatory activity of Salvia officinalis L. leaves: The relevance of ursolic acid. J Ethnopharm 2001; 75: 125-32
14. Hitziger T, Holl P, Ramadan M, Dettmering D, Imming P, Hempel B. Phytopharmacy: The old and forever young chamomile. Pharm Ztg 2003; 148: 22-30
15. Garcia-Argaez AN, Ramirez Apan TO, Parra Delgado H, Velazquez G, Martinez-Vazquez M. Anti-inflammatory activity of coumarins from Decatropis bicolor on TPA ear mice model. Planta Med 2000; 66: 279-81
16. De Leon EJ; Olmeto DA, Solis PN, Gupta MP, Terencio MC, Diayangambin exerts immunosuppressive and anti-inflammatory effects in vitro and in vivo. Planta Med 2002; 68: 1128-31
17. Cho JY, Kim AR, Park MH. Lignans from the rhizomes of Coptis japonica differentially act as anti-inflammatory principles. Planta Med 2001; 67: 312-6
18. Singh S. Comparative evaluation of anti-inflammatory potential of fixed oil of different Ocimum species and its possible mechanism of action. Indian J Exp Biol 1998; 36: 1028-31
19. Suzuki R, Shimizu T, Kudo T, Ohtsuka Y, Yamashiro Y, Oshida K. Effects of n-3 polyunsaturated fatty acids on dermatitis in NC/Nga mice. Prostaglandins Leukot Essent Fatty Acids, 2002: 435-40
20. Dorsch W, Schneider E, Bayer T, Breu W, Wagner H. Anti-inflammatory effects of onions: Inhibition of chemotaxis of human polymorphonuclear leukocytes by thiosulfinates and cepaenes. Int Arch Allergy Appl Immunol 1990; 92: 39-42
21. Müller AA, Reiter SA, Heider KG, Wagner H. Plant-derived acetophenones with antiasthmatic and anti-inflammatory properties: Inhibitory effects on chemotaxis, right angle light scatter and actin polymerization of polymorphonuclear granulocytes. Planta Med 1999; 65: 590-4
22. Konishi K, Urada M, Adachi I, Tanaka T. Inhibitory effect of sanguiin H-11 on chemotaxis of neutrophils. Biol Pharm Bull 2000; 23: 213-8