Characterization of B- and T-cell responses and HLA-DR4 binding motifs of the latex allergen Hev b 6.01 (prohevein) and its post-transcriptionally formed proteins Hev b 6.02 and Hev b 6.03

Allergy: European Journal of Allergy and Clinical Immunology

Volumn 59, Issue 7, 2004, Pages 724-733

  Raulf Heimsoth, M ^a   Rozynek, P ^a   Bruning T ^a   Rihs, H P ^a  

^a RUHR UNIVERSITY BOCHUM   (Germany)

Author keywords

HLA binding motif; IgE binding capacity; Latex allergy; Prohevein; Recombinant latex allergens; T cell reactive regions

Indexed keywords

AGGLUTININ; ALANINE; ALLERGEN; CYSTEINE; EPITOPE; HEVEIN; HLA ANTIGEN CLASS 2; HLA DP ANTIGEN; HLA DQ ANTIGEN; HLA DR ANTIGEN; HLA DR4 ANTIGEN; HYBRID PROTEIN; IMMUNOGLOBULIN E; IMMUNOGLOBULIN E ANTIBODY; LATEX; MALTOSE; MONOCLONAL ANTIBODY; PROHEVEIN; PROTEIN; PROTEIN HEV B.02; PROTEIN HEV B6.03; PROTEIN PRECURSOR; SERINE; UNCLASSIFIED DRUG;

ADULT; ALGORITHM; ALLERGY; AMINO ACID SUBSTITUTION; ARTICLE; ASTHMA; B LYMPHOCYTE; BINDING AFFINITY; CELL PROLIFERATION; CELL SUSPENSION; CLINICAL ARTICLE; COMPUTER ANALYSIS; CONJUNCTIVITIS; CONTACT URTICARIA; CONTROLLED STUDY; FEMALE; GERM CELL; HEALTH CARE PERSONNEL; HUMAN; HUMAN CELL; LYMPHOCYTE ACTIVATION; LYMPHOCYTE PROLIFERATION; MALE; PATIENT; PERIPHERAL BLOOD MONONUCLEAR CELL; PRECURSOR; PREDICTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN MODIFICATION; PROTEIN MOTIF; RHINITIS; SAMPLE; SERUM; T LYMPHOCYTE;

ADULT; ALGORITHMS; ALLERGENS; AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANTIMICROBIAL CATIONIC PEPTIDES; B-LYMPHOCYTES; EPITOPES, T-LYMPHOCYTE; FEMALE; HEALTH PERSONNEL; HLA-DR4 ANTIGEN; HUMANS; IMMUNOGLOBULIN E; LATEX; LATEX HYPERSENSITIVITY; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PLANT LECTINS; PLANT PROTEINS; PREDICTIVE VALUE OF TESTS; PROTEIN PROCESSING, POST-TRANSLATIONAL; T-LYMPHOCYTES;

EID: 3042701432     PISSN: 01054538     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1398-9995.2004.00475.x     Document Type: Article

References (36)

1. BEEZHOLD DH, SUSSMAN GL, LISS GM, CHANG NS. Latex allergy can induce clinical reactions to specific foods. Clin Exp Allergy 1996;26:416-422.
2. SLATER JE. Latex allergy. J Allergy Clin Immunol 1994;94:139-149.
3. POLEY GE, Jr, SLATER JE. Latex allergy. J Allergy Clin Immunol 2000;105: 1054-1062.
4. TURJANMAA K, ALENIUS H, MAKINEN-KILJUNEN S, REUNALA T, PALOSUO T. Natural rubber latex allergy. Allergy 1996;51:593-602.
5. BREITENEDER H, SCHEINER O. Molecular and immunological characteristics of latex allergens. Int Arch Allergy Immunol 1998;116:83-92.
6. ALENIUS H, KALKKINEN M, LUKKA M, REUNALA T, TURJANMAA K, MÄKINEN-KILJUNEN S et al. Prohevein from the rubber tree (Hevea brasiliensis) is a major latex allergen. Clin Exp Allergy 1995;24:659-665.
7. LEE HI, BROKAERT WF, RAIKHEL NV. Co- and post-translational processing of the hevein preprotein of latex of the rubber tree. J Biol Chem 1991;266:15944-15948.
8. BROEKAERT WF, LEE HI, KUSH A, CHUA NH, RAIKHEL N. Wound-induced accumulation of mRNA containing a hevein sequence in laticifers of rubber tree (Hevea brasiliensis). Proc Natl Acad Sci USA 1990;87:7633-7637.
9. ASENIO JL, CANADA FJ, BRUIX M, RODRIGUEZ-ROMERO A, JIMENEZ-BARBERO J. The interaction of hevein with N-acetylglucosamine-containing oligosaccharides. Solution structure of hevein complexed to chitobiose. Eur J Biochem 1995;230:621-633.
10. RAULF-HEIMSOTH M, POSCH A, CHEN Z, BAUR X. Cross-reactivity between natural rubber latex and food allergens. Environ Toxicol Pharmacol 1997;4: 169-173.
11. ALENIUS H, KALKKINEN M, REUNALA T, TURJANMAA K, PALOSUO T. The main IgE-binding epitope of a major latex allergen, prohevein, is present in its N-terminal 43 amino acid fragment, hevein. J Immunol 1996;156:1618-1625.
12. CHEN Z, POSCH A, LOHAUS C, RAULF-HEIMSOTH M, MEYER H, BAUR X. Isolation and identification of hevein as a major IgE-binding polypeptide in latex from Hevea brasiliensis. J Allergy Clin Immunol 1997;99:402-409.
13. BANERJEE B, WANG X, KELLY KJ, FINK JN, SUSSMAN GL, KURUP VP. IgE from latex-allergic patients binds to cloned and expressed B cell epitopes of prohevein. J Immunol 1997;159:5724-5732.
14. KARISOLA P, ALENIUS H, MIKKOLA J, KALKKINEN N, HELIN J, PENTIKAINEN OT et al. The major conformational IgE-binding epitopes of hevein (Hev b6.02) are identified by a novel chimera-based allergen epitope mapping strategy. J Biol Chem 2002;277:22656-22661.
15. POSCH A, WHEELER CH, CHEN Z, FLAGGE A, DUNN MJ, RAULF-HEIMSOTH M et al. Class I endochitinase containing a hevein domain is the causative allergen in latex-associated avocado allergy. Clin Exp Allergy 1999;29:667-672.
16. MIKKOLA JH, ALENIUS H, KALKKINEN N, TURJANMAA K, PALOSUO T, REUNALA T. Hevein-like protein domains as a possible cause for allergen cross-reactivity between latex and banana. J Allergy Clin Immunol 1998;102:1005-1012.
17. ROZYNEK P, POSCH A, BAUR X. Cloning, expression and characterization of the major latex allergen prohevein. Clin Exp Allergy 1998;28:1418-1426.
18. MAX H, HALDER T, KALBUS M, GNAU V, JUNG G, KALBACHER H. A 16mer peptide of the human autoantigen calreticulin is a most prominent HLA-DR4Dw4-associated self-peptide. Hum Immunol 1994;41:39-45.
19. BROWN J, JARDETZKY T, GORGA JC, STERN LJ, URBAN RG, STROMINGER JL et al. Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1. Nature 1993;364:33-39.
20. STERN LJ, BROWN JH, JARDETZKY TS, GORGA JC, URBAN RG, STROMINGER JL et al. Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide. Nature 1994;368:215-221.
21. HAMMER J, VALSASNINI P, TOLBA K, BOLIN D, HIGELIN J, TAKAES B et al. Promiscuous and allele-specific anchors in HLA-DR-binding peptides. Cell 1993;74:197-203.
22. RAMMENSEE HG, FRIEDE T, STEVANOVIC S. MHC ligands and peptide motifs: first listing. Immunogenetics 1995;41: 178-228.
23. HANDTMANN DS. Untersuchung linearer B-Zell-Epitope des Massernvirus-Fusionsproteins mit Rekonvaleszentenseren. Inaugural-Disseration, University of Tübingen, Tübingen, 1996.
24. RAULF-HEIMSOTH M, CHEN Z, LIEBERS V, ALLMERS H, BAUR X. Lymphocyte proliferation response to extracts from different latex materials and to the purified latex allergen Hev b 1 (rubber elongation factor). J Allergy Clin Immunol 1996;98:640-651.
25. RAULF-HEIMSOTH M, CHEN Z, RIHS HP, KALBACHER H, LIEBERS V, BAUR X. Analysis of T-cell-reactive regions and HLA-DR4 binding motifs on the latex allergen Hev b1 (rubber elongation factor). Clin Exp Allergy 1998;28:339-348.
26. JOHNSON BD, KURUP VP, SUSSMAN GL, ARIF SA, KELLY KJ, BEEZHOLD DH et al. Purified and recombinant latex proteins stimulated peripheral blood lymphocytes of latex allergic patients. Int Arch Allergy Immunol 1999;120: 270-279.
27. RIHS HP, CHEN Z, CREMER R, BAUR X. HLA class II antigens DR4 and DQ8 are associated with allergy to hevein, a major allergen of Hevea latex. Tissue Antigens 1997;49:92-95.
28. RIHS HP, CHEN Z, RUËFF F, CREMER R, RAULF-HEIMSOTH M, BAUR X et al. HLA-DQ8 and the HLA-DQ8-DR4 haplotype are positively associated with the hevein-specific IgE immune response in health care workers with latex allergy. J Allergy Clin Immunol 2002;110: 507-514.
29. CHEN Z, van KAMPEN V, RAULF-HEIMSOTH M, BAUR X. Allergenic and antigenic determinants of latex allergen Hev b 1: peptide mapping of epitopes recognized by human, murine and rabbit antibodies. Clin Exp Allergy 1996;26:406-415.
30. RAMMENSEE HG. Chemistry of peptides associated with MHC class I and class II molecules. Curr Opin Immunol 1995;7:85-96.
31. RAMMENSEE HG. Antigen presentation - recent developments. Int Arch Allergy Immunol 1996;110:299-307.
32. SINIGAGLIA F, HAMMER J. Defining rules for the peptide-MHC class II interaction. Curr Opin Immunol 1994;6:52-56.
33. KAWOK WW, GEBE JA, LIU A, AGAR S, PTACEK N, HAMMER J et al. Rapid epitope identification from complex class-II-restricted T-cell antigens. Trends Immunol 2002;22:583-588.
34. HAMMER J, TAKACS B, SINIGAGLIA F. Identification of a motif for HLA-DR1 binding peptides using M13 display libraries. J Exp Med 1992;176:1007-1013.
35. BEEZHOLD DH, KOSTYAL DA, SUSSMAN GL. IgE epitope analysis of the hevein preprotein: a major latex protein allergen. Clin Exp Immunol 1997;108: 114-121.
36. VIRTANEN T, ZEILER T, MÄNTYJÄRVI R. Important animal allergens are lipocalin proteins: why are they allergenic? Int Arch Allergy Immunol 1999;120: 247-258.