Efficacy of IgG, Fab, and F(ab')2 fragments of horse antivenom in the treatment of local symptoms after Cerastes cerastes (Egyptian snake) bite

African Journal of Biotechnology

Volumn 2, Issue 7, 2003, Pages 197-205

  Abdel Latif, Salwa S ^a   Wanas, Soheir ^a   Malak, George Abdel ^a   Helmy, Madiha H ^b  

^a VACSERA   (Egypt)

^b ALEXANDRIA UNIVERSITY   (Egypt)

Author keywords

Cerastes cerastes; Egyptian snake; F(ab')2; Fab; IgG

Indexed keywords

IMMUNOGLOBULIN F(AB')2 FRAGMENT; IMMUNOGLOBULIN F(AB) FRAGMENT; IMMUNOGLOBULIN G; SNAKE VENOM; SNAKE VENOM ANTISERUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY PRODUCTION; ANTIGEN BINDING; ARTICLE; BLEEDING; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG EFFICACY; EDEMA; ENVENOMATION; HORSE; MOUSE; MUSCLE NECROSIS; NONHUMAN; SNAKE; SNAKEBITE;

ANIMALIA; CERASTES; CERASTES CERASTES; EQUUS CABALLUS; SERPENTES;

EID: 3042693657     PISSN: 16845315     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Chaves F, Borboza M, Gutierrez JM (1995). Pharmacological study of oedema induced by venom of the snake Sanitaria. Panamericana 88:184-196.
2. Choumet V, Audebert F, Riviere G, Sorkine M, Urtizberea M, Sabouraud A, Scherrmann JM, Bon C (1996). Toxicokinetics of vipra aspts in venpming and antivenom therapy, In; Bon. C. Goyffon, M. (Eds), envenomings and their treatments. Edition fondation Marcel Merieux. Lyon. pp. 127-133.
3. 2 Fab in mice. Cancer Res. 46: 3969-3978.
4. Dart RC, Horowitz RS (1996). Use of antibodies as antivenoms: a primitive solution for a complex problem? In: Bon C, Goyffon M (Eds.). Envonoming and their treatments. Editions Fondation Marcel Merieux. Lyon, pp. 83-94.
5. 2 anti-snake venom by caprylic acid: A fast method for obtaining IgG fragments with large neutralization activity, purity and yield. Toxicon. 27: 297-303.
6. Estrada R, Chaves F, Robles A, Rojas E, Gutierrez JM (1992). Valores Hematologicos y de enzymas sericas en caballos inoculados con venenos de Serpients para la produccion de antivenenos en Costa Rica. Rev. Biol. Trop. 40: 95-99.
7. Grechushkina-Sukhorukova VA, Telbukh VP, Stepepanov VM (1984). Proteolysis of horse blood serum proteins at various stages of antitoxic sera production by the Diaferm-3-Method. Prikl. Biokhim. Mikrobiol. 20: 528-533.
8. Gutierrez JM, Arroyo O, Balanos R (1980). Mionecrosis,hemorragia y edema inducidos por el veneno de Bothrops asper en ratio blanco. Toxicon. 18:603-610.
9. Gutierrez JM, Chaves F, Bolanos R, Cerdas L, Rojas e Arroyo O, Portilla E (1981). Neutralizacion de los efectos locales del veneno de Bothrops asper por un antiveneno polivalente. Toxicon. 19:493-500.
10. Gutierrez JM, Ownby CL, Odell GV (1984). Pathogenesis of myonecrosis induced by crude venom and a myotoxin of Bothrops asper. Exp. Mol. Pathol. 40: 367-379.
11. Gutierrez JM, Gene JA, Rojas G, Cerdas L (1985). Neutralization of proteolytic and haemorrhagic activities of Costa Rican snake venoms by a polyvalent antivenom. Toxicon. 23: 887-893.
12. Gutierrez JM, Rojas G, Lomonte B, Gene JA, Cerdas L (1986). Comparative study of the oedema-forming activity of Costa Rican snake venoms and its neutralization of a polyvalent antivenom. Comp. Biochem. Physiol. 85C: 171-175.
13. Gutierrez JM (1995). Clinical toxicology of snake bite in central America. In: Meier. J., White, J. (Eds), Handbook of clinical toxicology of animal venoms and poisons. CRC Press. Boca Raton, Fl. Pp. 645-665.
14. Gutierrez JM, Leon G, Rojas G, Lomonte B, Rucavado A, Chaves F (1998). Neutralization of ocal tissue damage induced by Bothrops asper (terciopelo) snake venom. Toxicon. 36: 1529-1538.
15. Karlson-Stiber C, Presson H, Smith D, Al-abdulla IH, Sjostrom L (1997). First clinical experiences with specific sheep Fab fragments in snake bite. Report of a multicentre study of Vipera berus envenoming. J. Intern. Med. 241: 53-58.
16. Landon J, Smith DC (1996). Development of novel antivenoms based on specific ovine Fab. In: Bon, C., Goyffon, M. (Eds.), Envenomings and Their Tratments. Editions Fondation Marcel Merieux, Lyon, pp. 173-180.
17. Laing GD, Lee L, Smith DC, Landon J, Theakston RGD (1995). Experimental assessment of a new, low-cost antivenom for treatment of carpet viper (Echis ocellatus) envenoming. Toxicon 33, 307-313.
18. Leon G, Valverdo JM, Rojas G, Gutierrez JM (2000). Comparative study on the ability of IgG and Fab sheep antivenoms to neutralize local hemorrhage, oedema and myonecrosis induced by Bothrops asper snake venom. Toxicon. 38: 233-244.
19. Lomonte B, Lundgren J, Johansson B, Bagge U (1994). The dynamics of local tissue damage induced by Bothrops asper snake venom and myotoxin II on the mouse cremaster muscles an intravital and electron microscopic study. Toxicon. 32: 41-55.
20. Meyer WP, Habib AG, Onayade AA, Yakubu A, Smith DC, Naidi A, Daudu IJ, Warrell DA, Theakston RDG (1997). First clinical experiences with a new ovine Fab Echis ocellatus snake bite antivenom in Nigeria: randomized comparative trial with Institute Pasteur serum (IPSER) Africa antivenom. Am. J. Trop. Med. Hyg. 56: 291-300.
21. 2 fragments. Toxicon. 32: 725-734.
22. Moreira L, Gutierrez JM, Borkow G, Ovadia M (1992). Ultrastructural alternations in mouse capillary blood vessels after experimental injection of venom from snake Bothrops asper. Exp. Mol. Pathol. 57: 124-133.
23. Ownby CL (1982). Pathology of rattlesnake envenomation. In: Tu AT (Ed.). Rattlesnake venoms. Their action and treatment. Marcel Dekker, New York. Pp. 163-209.
24. Perez JC, Garcia VE, Huang SY (1984). Production of monoclonal antibody against hemorrhagic activity of Crotatus atrox (Western diamonback rattlesnake) venom. Toxicon 22:967.
25. Pope CG (1939). The action of proteolytic enzymes on antitoxins and protein in immune sera .I. True digestion of the proteins. Br. J. Exp. Path. 20: 132.
26. Raw L., Guidolin, R., Higashi, H.G. and Kelen, E.M.A. (1991). Antivenin in Brazil: Preparation. In: Handbook of Natural toxins, vol.5, Reptile venoms and toxins pp. 557-581. (Tu,A.T.,Ed). New york: Marcel Dekker.
27. Riviere G, Choumet V, Audebert F, Sabouraud A, Debray M, Scherrmann JM, Bon C (1997). Effect of antivenom on venom pharmacokinetics in expermentally envenomed rabbits: toward an optimization of antivenom therapy. J. Pharmacol. Exp. Ther. 281: 1-8.
28. Rojas G, Jimenez JM, Gutierrez JM (1994). Caprylic acid fraction of hyperimmune horse plasma: Description of a simple procedure for antivenom production. Toxicon. 32: 351-363.
29. Scherrmann JM (1994). Antibody treatment of toxic poisoning, recent advances. Clin. Toxicol. 32: 363-375.