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Volumn 8, Issue 3, 2004, Pages 360-362

An improved process for the preparation of trimethylhydrazine and its coupling with an activated acid intermediate

Author keywords

[No Author keywords available]

Indexed keywords

ACID; HYDRAZINE DERIVATIVE; TRIMETHYLHYDRAZINE; UNCLASSIFIED DRUG;

EID: 3042690482     PISSN: 10836160     EISSN: None     Source Type: Journal    
DOI: 10.1021/op0342022     Document Type: Article
Times cited : (9)

References (25)
  • 3
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    • EP 430033 A2 19910605, 1991
    • (c) Riebli, P. EP 430033 A2 19910605, 1991.
    • Riebli, P.1
  • 6
    • 3042513486 scopus 로고    scopus 로고
    • U.S. Patent 19650506, 1967
    • (f) Lowrie, H. S. U.S. Patent 19650506, 1967.
    • Lowrie, H.S.1
  • 7
    • 3042660274 scopus 로고    scopus 로고
    • U.S. Patent 19670509, 1967
    • (g) Levitt, G. U.S. Patent 19670509, 1967.
    • Levitt, G.1
  • 12
    • 3042658396 scopus 로고    scopus 로고
    • U.S. Patent 3,182,087, 1965
    • (a) Horvitz, D. U.S. Patent 3,182,087, 1965.
    • Horvitz, D.1
  • 13
    • 3042613488 scopus 로고    scopus 로고
    • U.S. Patent 3,517,064, 1970
    • (b) Sidi, H.; Paramus, N. J. U.S. Patent 3,517,064, 1970.
    • Sidi, H.1    Paramus, N.J.2
  • 20
    • 3042611644 scopus 로고    scopus 로고
    • note
    • 1H NMR spectra.
  • 21
    • 0017702857 scopus 로고
    • For information on the toxicity of TMH, see: Toth, B. Cancer 1977, 40, 2427.
    • (1977) Cancer , vol.40 , pp. 2427
    • Toth, B.1
  • 23
    • 3042660273 scopus 로고    scopus 로고
    • note
    • The difference of boiling temperatures between TMH (bp 59-61°C) and 1,4-dioxane (bp 100°C) would allow obtaining higher concentrations of TMH provided a fractionating column was used.
  • 24
    • 0007193238 scopus 로고    scopus 로고
    • The choices of coupling agents were made on the basis of the reported effectiveness of phosphinic reagents in the coupling of hindered amino acids and on the fact that PyBrop had been employed in this coupling with moderate success. See: Humphrey, J. M.; Chamberlin, A. R. Chem. Rev. 1997, 97, 2243.
    • (1997) Chem. Rev. , vol.97 , pp. 2243
    • Humphrey, J.M.1    Chamberlin, A.R.2
  • 25
    • 3042609841 scopus 로고    scopus 로고
    • note
    • 2).


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.