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For a discussion of the complexation on aluminum ions with polydentate ligands such as ethylene glycol, see: McMahon, C. N.; Alemany, L.; Callender, R. L.; Bott, S. G.; Barron, A. R. Chem. Mater. 1999, 11, 3181.
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3042611644
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1H NMR spectra.
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23
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3042660273
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note
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The difference of boiling temperatures between TMH (bp 59-61°C) and 1,4-dioxane (bp 100°C) would allow obtaining higher concentrations of TMH provided a fractionating column was used.
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24
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0007193238
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The choices of coupling agents were made on the basis of the reported effectiveness of phosphinic reagents in the coupling of hindered amino acids and on the fact that PyBrop had been employed in this coupling with moderate success. See: Humphrey, J. M.; Chamberlin, A. R. Chem. Rev. 1997, 97, 2243.
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25
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3042609841
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note
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2).
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