Anti-clastogenic activity of two structurally related pterocarpans purified from Bituminaria bituminosa in cultured human lymphocytes

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 561, Issue 1-2, 2004, Pages 75-81

  Maurich, T ^a   Pistelli, L ^b   Turchi, G ^a  

^a CNR   (Italy)

^b UNIVERSITY OF PISA   (Italy)

Author keywords

Anti clastogenicity; Bleomycin; Human lymphocytes; Micronuclei; Mitomycin C; Pterocarpans

Indexed keywords

BITUCARPIN A; BLEOMYCIN; CLASTOGEN; ERYBRAEDIN C; FLAVONOID; MITOMYCIN C; PTEROCARPAN DERIVATIVE; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BITUMINARIA BITUMINOSA; CELL PROLIFERATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG DETERMINATION; DRUG PURIFICATION; DRUG STRUCTURE; HUMAN; HUMAN CELL; INCUBATION TIME; LYMPHOCYTE CULTURE; MALE; MEDICINAL PLANT; MICRONUCLEUS; MITOSIS INDEX; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

ANALYSIS OF VARIANCE; ANTIMUTAGENIC AGENTS; BLEOMYCIN; CELL DIVISION; FABACEAE; HUMANS; LYMPHOCYTES; MICRONUCLEUS TESTS; MITOMYCIN; PTEROCARPANS;

BITUMINARIA BITUMINOSA;

EID: 3042685135     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2004.03.006     Document Type: Article

References (26)

1. Casagrande F., Darbon J.M. Effects of structurally related flavonoids on cell cycle progression of human melanoma cells: regulation of cyclin-dependent kinases. Biochem. Pharmacol. 61:2001;1205-1215
2. Hertog M.G.L., Feskens E.J.M., Hollmann P.C.H., Katan M.B., Kromhout D. Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen elderly study. Lancet. 342:1993;1007-1011
3. Rimm E.B., Katan M.B., Ascherio A., Stampfer M.J., Willet W.C. Relation between intake of flavonoids and risk for coronary heart disease in male health professionals. Ann. Intern. Med. 125:1996;384-389
4. Havsteen B.T. The biochemistry and medical significance of the flavonoids. Pharmacol. Ther. 96:2002;67-202
5. Heim K.E., Tagliaferro A.R., Bobilya D.J. Flavonoid antioxidants: chemistry, metabolism and structure-activity relationships. J. Nutr. Biochem. 13:2002;572-584
6. Cao G., Sofic E., Prior R.L. Antioxidant and prooxidant behaviour of flavonoids: structure-activity relationships. Free Radic. Biol. Med. 22:1997;749-760
7. Steele C.L., Gijzen M., Qutob D., Dixon R.A. Molecular characterization of the enzyme catalyzing the aryl migration reaction of iso-flavonoid biosynthesis in soybean. Arch. Biochem. Biophys. 367:1999;146-150
8. P.M. Dewich, Iso-flavonoids, in: J.B. Harborne (Ed.), The Flavonoids: Advances in Research Since 1980, Chapman and Hall, London, 1988, pp. 125-204.
9. Pistelli L., Noccioli C., Appendino G., Bianchi F., Sterner O., Ballero M. Pterocarpans from Bituminaria morisiana and Bituminaria bituminosa. Phytochemistry. 64:2004;595-598
10. Mitscher L.A., Okwute S.K., Gollapudi S.R., Drake S., Avona E. Antimicrobial pterocarpans of Nigerian Erythrina mildbraedii. Phytochemistry. 27:1988;3449-3452
11. Nkengfack A.E., Vardamides J.C., Formum Z.T., Meyer M. Prenylated isoflavanone from Erythrina eriothricha. Phytochemistry. 40:1995;1803-1808
12. Fenech M. The cytokinesis-block micronucleus technique: a detailed description of the method and its application to genotoxicity studies in human populations. Mutat. Res. 285:1993;35-44
13. Scarpato R., Migliore L., Angotzi G., Fedi A., Militi L., Loprieno N. Cytogenetic monitoring of a group of Italian floriculturists: no evidence of DNA damage related to pesticide exposure. Mutat. Res. 367:1996;73-82
14. Mir L.M., Tounekti O., Orlowski S. Bleomycin: revival of an old drug. Gen. Pharmacol. 27:1996;745-748
15. Stubbe J., Kozarich J.W. Mechanisms of bleomycin-induced DNA degradation. Chem. Rev. 87:1987;1107-1136
16. Burger R.M., Peisach J., Blumberg W.E., Horwitz S.B. Iron-bleomycin interactions with oxygen and oxygen analogues: effects on spectra and drug activity. J. Biol. Chem. 254:1979;10906-10911
17. Povirk L.F. DNA damage and mutagenesis by radiomimetic DNA-cleaving agents: bleomycin, neocarzinostatin an other enediynes. Mutat. Res. 355:1996;71-89
18. Byrnes R.W., Petering D.H. DNA strand breakage in isolated nuclei subjected to bleomycin or hydrogen peroxide. Biochem. Pharmacol. 48:1994;575-582
19. Morel I., Lescoat G., Cogrel P., Sergent O., Pasdeloup N., Brissot P., Cillard P., Cillard J. Antioxidant and iron-chelating activities of the flavonoids catechin, quercitin and diosmetin on iron-loaded rat hepatocyte cultures. Biochem. Pharmacol. 45:1993;13-19
20. Morel I., Lescoat G., Cillard P., Cillard J. Role of flavonoids and iron chelation in antioxidant action. Methods Enzymol. 243:1994;437-443
21. Arora A., Nair M.G., Strasburg G.M. Structure-activity relationships for antioxidant activities of a series of flavonoids in a liposomal system. Free Radic. Biol. Med. 24:1998;1355-1363
22. 4-induced microsomal lipid peroxidation. Experentia. 47:1991;195-199
23. Cook N.C., Sammm S. Flavonoids: chemistry, metabolism, cardioprotective effects, and dietary source. Nutr. Biochem. 7:1995;66-76
24. Sartorelli A.C., Hodnik W.F., Belcourt M.F. Mitomycin C: a prototype bioreductive agent. Oncol. Res. 6:1994;501-508
25. Cummings J., Spanswick V.J., Smyth J.F. Re-evaluation of the molecular pharmacology of mitomycin C. Eur. J. Cancer. 31A:1995;1928-1933
26. Cummings J. The role of reductive enzymes in cancer cell resistance to mitomycin C. Drug Resist. Updat. 3:2000;143-148