Pharmacologic inhibition of nitric oxide synthases and cyclooxygenases enhances intimal hyperplasia in balloon-injured rat carotid arteries

Journal of Vascular Surgery

Volumn 40, Issue 1, 2004, Pages 115-122

  Fischer, Jens W ^a,c   Hawkins, Suzanne ^b   Clowes, Alexander W ^b  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY HOSPITAL DÜSSELDORF   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BROXURIDINE; DRINKING WATER; FORMALDEHYDE; INDOMETACIN; N(G) NITROARGININE; NITRIC OXIDE SYNTHASE; PARAFFIN; PENTOBARBITAL; PROSTAGLANDIN SYNTHASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY INTIMA PROLIFERATION; ARTICLE; BALLOON CATHETER; CAROTID ARTERY; CAROTID ARTERY INJURY; CELL DENSITY; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; DISEASE COURSE; ENZYME SYNTHESIS; FEEDING; INTIMA; MALE; MORPHOMETRICS; NONHUMAN; PRIORITY JOURNAL; RAT; RAT STRAIN; SMOOTH MUSCLE FIBER; TUNICA MEDIA;

ANGIOPLASTY, BALLOON; ANIMALS; CAROTID ARTERIES; CAROTID ARTERY INJURIES; CYCLOOXYGENASE INHIBITORS; ENZYME INHIBITORS; HYPERPLASIA; INDOMETHACIN; MALE; MODELS, ANIMAL; NITRIC OXIDE SYNTHASE; NITROARGININE; RATS; RATS, INBRED F344; TUNICA INTIMA;

EID: 3042663092     PISSN: 07415214     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jvs.2004.03.037     Document Type: Article

References (41)

1. Lindner V., Reidy M.A. Proliferation of smooth muscle cells after vascular injury is inhibited by an antibody against basic fibroblast growth factor. Proc Natl Acad Sci U S A. 88:1991;3739-3743
2. Jackson C.L., Raines E.W., Ross R., Reidy M.A. Role of endogenous platelet-derived growth factor in arterial smooth muscle cell migration after balloon catheter injury. Arterioscler Thromb. 13:1993;1218-1226
3. Jawien A., Bowen-Pope D.F., Lindner V., Schwartz S.M., Clowes A.W. Platelet-derived growth factor promotes smooth muscle migration and intimal thickening in a rat model of balloon angioplasty. J Clin Invest. 89:1992;507-511
4. Clowes A.W., Reidy M.A., Clowes M.M. Kinetics of cellular proliferation after arterial injury. I Smooth muscle growth in the absence of endothelium. Lab Invest. 49:1983;327-333
5. Clowes A.W., Reidy M.A., Clowes M.M. Mechanisms of stenosis after arterial injury. Lab Invest. 49:1983;208-215
6. Garg U.C., Hassid A. Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells. J Clin Invest. 83:1989;1774-1777
7. Guo K., Andres V., Walsh K. Nitric oxide-induced downregulation of Cdk2 activity and cyclin A gene transcription in vascular smooth muscle cells. Circulation. 97:1998;2066-2072
8. von der Leyen H.E., Gibbons G.H., Morishita R., Lewis N.P., Zhang L., Nakajima M., et al. Gene therapy inhibiting neointimal vascular lesion in vivo transfer of endothelial cell nitric oxide synthase gene. Proc Natl Acad Sci U S A. 92:1995;1137-1141
9. Chen L., Daum G., Forough R., Clowes M., Walter U., Clowes A.W. Overexpression of human endothelial nitric oxide synthase in rat vascular smooth muscle cells and in balloon-injured carotid artery. Circ Res. 82:1998;862-870
10. Janssens S., Flaherty D., Nong Z., Varenne O., van Pelt N., Haustermans C., et al. Human endothelial nitric oxide synthase gene transfer inhibits vascular smooth muscle cell proliferation and neointima formation after balloon injury in rats. Circulation. 97:1998;1274-1281
11. Shears L.L. Jr, Kibbe M.R., Murdock A.D., Billiar T.R., Lizonova A., Kovesdi I., et al. Efficient inhibition of intimal hyperplasia by adenovirus-mediated inducible nitric oxide synthase gene transfer to rats and pigs in vivo. J Am Coll Surg. 187:1998;295-306
12. Morishita T., Tsutsui M., Shimokawa H., Horiuchi M., Tanimoto A., Suda O., et al. Vasculoprotective roles of neuronal nitric oxide synthase. FASEB J. 16:2002;1994-1996
13. Yogo K., Shimokawa H., Funakoshi H., Kandabashi T., Miyata K., Okamoto S., et al. Different vasculoprotective roles of NO synthase isoforms in vascular lesion formation in mice. Arterioscler Thromb Vasc Biol. 20:2000;E96-100
14. Chyu K.Y., Dimayuga P., Zhu J., Nilsson J., Kaul S., Shah P.K., et al. Decreased neointimal thickening after arterial wall injury in inducible nitric oxide synthase knockout mice. Circ Res. 85:1999;1192-1198
15. Mukherjee D., Nissen S.E., Topol E.J. Risk of cardiovascular events associated with selective COX-2 inhibitors. JAMA. 286:2001;954-959
16. Pratico D., Tillmann C., Zhang Z.B., Li H., FitzGerald G.A. Acceleration of atherogenesis by COX-1-dependent prostanoid formation in low density lipoprotein receptor knockout mice. Proc Natl Acad Sci U S A. 98:2001;3358-3363
17. Burleigh M.E., Babaev V.R., Oates J.A., Harris R.C., Gautam S., Riendeau D., et al. Cyclooxygenase-2 promotes early atherosclerotic lesion formation in LDL receptor-deficient mice. Circulation. 105:2002;1816-1823
18. Clowes A.W., Karnovsky M.J. Failure of certain antiplatelet drugs to affect myointimal thickening following arterial endothelial injury in the rat. Lab Invest. 36:1977;452-464
19. Maffia P., Ianaro A., Sorrentino R., Lippolis L., Maiello F.M., del Soldato P., et al. Beneficial effects of NO-releasing derivative of flurbiprofen (HCT-1026) in rat model of vascular injury and restenosis. Arterioscler Thromb Vasc Biol. 22:2002;263-267
20. Schrör K., Weber A.A. Roles of vasodilatory prostaglandins in mitogenesis of vascular smooth muscle cells. Agents Actions Suppl. 48:1997;63-91
21. Hasenstab D., Forough R., Clowes A.W. Plasminogen activator inhibitor type 1 and tissue inhibitor of metalloproteinase-2 increase after arterial injury in rats. Circ Res. 80:1997;490-496
22. Jeremy J.Y., Dandona P. Effect of endothelium removal on stimulatory and inhibitory modulation of rat aortic prostacyclin synthesis. Br J Pharmacol. 96:1989;243-250
23. Williams S.P., Campbell A.K., Roszell N., Myatt L., Leikauf G.D., Rapoport R.M. Modulation of phorbol ester-induced contraction by endogenously released cyclooxygenase products in rat aorta. Am J Physiol. 267:1994;H1654-1662
24. Joly G.A., Schini V.B., Vanhoutte P.M. Balloon injury induces nitric oxide synthase activity in rat carotid arteries. J Cardiovasc Pharmacol. 20:1992;S151-154
25. Yan Z., Hansson G.K. Overexpression of inducible nitric oxide synthase by neointimal smooth muscle cells. Circ Res. 82:1998;21-29
26. Gonzalez-Fernandez F., Lopez-Farre A., Rodriguez-Feo J.A., Farre J., Guerra J., Fortes J., et al. Expression of inducible nitric oxide synthase after endothelial denudation of the rat carotid artery role of platelets. Circ Res. 83:1998;1080-1087
27. Hansson G.K., Geng Y.J., Holm J., Hardhammar P., Wennmalm A., Jennische E. Arterial smooth muscle cells express nitric oxide synthase in response to endothelial injury. J Exp Med. 180:1994;733-738
28. Pritchard K.A. Jr, O'Banion M.K., Miano J.M., Vlasic N., Bhatia U.G., Young D.A., et al. Induction of cyclooxygenase-2 in rat vascular smooth muscle cells in vitro and in vivo. J Biol Chem. 269:1994;8504-8509
29. Rimarachin J.A., Jacobson J.A., Szabo P., Maclouf J., Creminon C., Weksler B.B. Regulation of cyclooxygenase-2 expression in aortic smooth muscle cells. Arterioscler Thromb. 14:1994;1021-1031
30. Bishop-Bailey D., Pepper J.R., Larkin S.W., Mitchell J.A. Differential induction of cyclooxygenase-2 in human arterial and venous smooth muscle role of endogenous prostanoids. Arterioscler Thromb Vasc Biol. 18:1998;1655-1661
31. Bosmans J.M., Vrints C.J., Kockx M.M., Bult H., Cromheeke K.M., Herman A.G. Continuous perivascular L-arginine delivery increases total vessel area and reduces neointimal thickening after experimental balloon dilatation. Arterioscler Thromb Vasc Biol. 19:1999;767-776
32. Nikkari S.T., Järveläinen H.T., Wight T.N., Ferguson M., Clowes A.W. Smooth muscle cell expression of extracellular matrix genes after arterial injury. Am J Pathol. 144:1994;1348-1356
33. Day A.J., Prestwich G.D. Hyaluronan-binding proteins tying up the giant. J Biol Chem. 277:2002;4585-4588
34. Zhang Y., Cao L., Yand B.L., Yang B.B. The G3 domain of versican enhances cell proliferation via epidermal growth factor-like motifs. J Biol Chem. 273:1998;21342-21351
35. Wight T.N., Lara S., Reissen R., LeBaron R., Isner J. Selective deposits of versican in the extracellular matrix of restenotic lesions from human peripheral arteries. Am J Pathol. 151:1997;963-973
36. Studer R.K., DeRubertis F.R., Craven P.A. Nitric oxide suppresses increases in mesangial cell protein kinase C, transforming growth factor beta, and fibronectin synthesis induced by thromboxane. J Am Soc Nephrol. 7:1996;999-1005
37. Chaux A., Ruan X.M., Fishbein M.C., Ouyang Y., Kaul S., Pass J.A., et al. Perivascular delivery of a nitric oxide donor inhibits neointimal hyperplasia in vein grafts implanted in the arterial circulation. J Thorac Cardiovasc Surg. 115:1998;604-612
38. Rizvi M.A., Myers P.R. Nitric oxide modulates basal and endothelin-induced coronary artery vascular smooth muscle cell proliferation and collagen levels. J Mol Cell Cardiol. 29:1997;1779-1789
39. Kolpakov V., Gordon D., Kulik T.J. Nitric oxide-generating compounds inhibit total protein and collagen synthesis in cultured vascular smooth muscle cells. Circ Res. 76:1995;305-309
40. Fitzsimmons C., Proudfoot D., Bowyer D.E. Monocyte prostaglandins inhibit procollagen secretion by human vascular smooth muscle cells implications for plaque stability. Atherosclerosis. 142:1999;287-293
41. Sinzinger H., Fitscha P., Kritz H. Antimitotic actions of vasodilatory prostaglandins clinical aspects. Agents Actions Suppl. 48:1997;92-106