Disease- or therapy-related bone marrow damage cannot be overcome by changes in stem cell source or dose in allogeneic transplantation

European Journal of Haematology

Volumn 73, Issue 1, 2004, Pages 1-9

  Novotny, J R ^a,b   Rosenthal, C ^a   Elmaagacli, A H ^a   Durig J ^a   Beelen, D W ^a   Duhrsen U ^a  

^a UNIVERSITY OF DUISBURG ESSEN   (Germany)

^b UNIVERSITY HOSPITAL ESSEN   (Germany)

Author keywords

Allogeneic stem cell transplantation; Bone marrow damage; Bone marrow transplantation; Cobble stone area forming cells; Peripheral blood stem cell transplantation; Stem cell dose; Stem cell source

Indexed keywords

IMMUNOSUPPRESSIVE AGENT;

ACUTE GRANULOCYTIC LEUKEMIA; ADULT; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; ARTICLE; BONE MARROW DISEASE; BONE MARROW TRANSPLANTATION; CELL ASSAY; CELL DENSITY; CHRONIC MYELOID LEUKEMIA; CLINICAL ARTICLE; COLONY FORMING CELL; COMPARATIVE STUDY; CONTROLLED STUDY; EARLY CANCER; FEMALE; GRAFT REJECTION; HEMATOPOIETIC STEM CELL; HUMAN; LEUKEMIA REMISSION; MALE; MICROENVIRONMENT; MYELODYSPLASTIC SYNDROME; PRIORITY JOURNAL; STATISTICAL ANALYSIS;

ADOLESCENT; ADULT; BONE MARROW CELLS; BONE MARROW DISEASES; BONE MARROW TRANSPLANTATION; CELL COUNT; FEMALE; GRAFT SURVIVAL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; LEUKEMIA, MYELOCYTIC, ACUTE; LEUKEMIA, MYELOID, CHRONIC; MALE; MIDDLE AGED; PERIPHERAL BLOOD STEM CELL TRANSPLANTATION; TRANSPLANTATION CONDITIONING; TRANSPLANTATION, HOMOLOGOUS;

EID: 3042663018     PISSN: 09024441     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0609.2004.00255.x     Document Type: Article

References (35)

1. PLOEMACHER RE. Stem cells: characterization and measurement. Baillieres Clin Haematol 1997; 10:429-444.
2. ARNOLD R, SCHMEISER T, HEIT W, FRICKHOFEN N, PABST G, HEIMPEL H, KUBANER B. Hemopoietic reconstitution after bone marrow transplantation. Exp Hematol 1986;14:271-277.
3. SELLERI C, MACIEJEWSKI JP, DE ROSA G, et al. Long-lasting decrease of marrow and circulating long-term culture initiating cells after allogeneic bone marrow transplant. Bone Marrow Transplant 1999;23:1029-1037.
4. PODESTA M, PIAGGIO G, FRASSONI F, PITTO A, MORDINI N, BREGANTE S, VALERIANI A, BACIGALUPO A. Deficient reconstitution of early progenitors after allogeneic bone marrow transplantation. Bone Marrow Transplant 1997;19:1011-1017.
5. KIRKLAND MA, SPENCER A, DAVIDSON RJ, MCDONALD C, GOLDMAN JM. Quantitation of mafosfamide-resistant precolony-forming units in allogeneic bone marrow transplantation: relationship with rate of engraftment and evidence for long-lasting reduction in stem cell numbers. Blood 1996;87:3963-3969.
6. DEXTER T, ALLEN T, LAJTHA L. Conditions controlling the proliferation of haemopoietic stem cells in vitro. J Cell Physiol 1977;91:335-344.
7. UDOMSAKDI C, LANSDORP PM, HOGGE DE, REID DS, EAVES AC, EAVES CJ. Characterization of primitive hematopoietic cells in normal human peripheral blood. Blood 1992;80:2513-2521.
8. SUTHERLAND HJ, EAVES CJ, EAVES AC, DRAGOWSKA W, LANSDORP PM. Characterization and partial purification of human marrow cells capable of initiating long-term hematopoiesis in vitro. Blood 1989;74:1563-1570.
9. PLOEMACHER RE, VAN DER SLUIJS JP, VOERMAN JS, BRONS NH. An in vitro limiting-dilution assay of long-term repopulating hematopoietic stem cells in the mouse. Blood 1989;74:2755-2763.
10. BREEMS DA, BLOKLAND EA, NEBEN S, PLOEMACHER RE. Frequency analysis of human primitive haematopoietic stem cell subsets using a cobblestone area forming cell assay. Leukemia 1994;8:1095-1104.
11. SUTHERLAND HJ, EAVES CJ, LANSDORP PM, THACKER JD, HOGGE DE. Differential regulation of primitive human hematopoietic cells in long-term cultures maintained on genetically engineered murine stromal cells. Blood 1991;78:666-672.
12. FAZEKAS S, GROTH S. The evaluation of limiting dilution assays. J Immunol Methods 1982;49:R11-R23.
13. TASWELL C. Limiting dilution assays for the determination of immunocompetent cell frequencies. I. Data analysis. J Immunol 1981;126:1614-1619.
14. DALY F, HAND DJ, JONES MC, LUNN AD, MCCONWAY KJ. Elements of Statistics. London: Addison Wesley, 1995.
15. SINGHAL S, POWLES R, KULKARNI S, et al. Comparison of marrow and blood cell yields from the same donors in a double-blind, randomized study of allogeneic marrow vs blood stem cell transplantation. Bone Marrow Transplant 2000;25:501-505.
16. HASSAN HT, STOCKSCHLADER M, SCHLEIMER B, KRUGER W, ZANDER AR. Comparison of the content and subpopulations of CD3 and CD34 positive cells in bone marrow harvests and G-CSF-mobilized peripheral blood leukapheresis products from healthy adult donors. Transplant Immunol 1996;4:319-323.
17. STEEN R, TJONNFJORD GE, EGELAND T. Comparison of the phenotype and clonogenicity of normal CD34+ cells from umbilical cord blood, granulocyte colony-stimulating factor-mobilized peripheral blood, and adult human bone marrow. J Hematother 1994;3:253-262.
18. THEILGAARD-MONCH K, RAASCHOU-JENSEN K, ANDERSEN H, RUSSELL CA, VINDELOV L, JACOBSEN N, DICKMEISS É. Single leukapheresis products collected from healthy donors after the administration of granulocyte colony-stimulating factor contain ten-fold higher numbers of longterm reconstituting hematopoietic progenitor cells than conventional bone marrow allografts. Bone Marrow Transplant 1999;23:243-249.
19. SCHMITZ N, BARRETT J. Optimizing engraftment - source and dose of stem cells. Semin Hematol 2002;39:3-14.
20. VOERMANS C, VAN HENNIK PB, VAN DER SCHOOT CE. Homing of human hematopoietic stem and progenitor cells: new insights, new challenges? J Hematother Stem Cell Res 2001;10:725-738.
21. GALOTTO M, BERISSO G, DELFINO L, et al. Stromal damage as consequence of high-dose chemo/radiotherapy in bone marrow transplant recipients. Exp Hematol 1999;27:1460-1466.
22. O'FLAHERTY E, SPARROW R, SZER J. Bone marrow stromal function from patients after bone marrow transplantation. Bone Marrow Transplant 1995;15:207-212.
23. DEL CANIZO C, LOPEZ N, CABALLERO D, FERNANDEZ E, BRUFAU A, VAZQUEZ L, MATEOS V, GUTIERREZ N, SAN MIGUEL JF. Haematopoietic damage persists 1 year after autologous peripheral blood stem cell transplantation. Bone Marrow Transplant 1999;23:901-905.
24. DÜHRSEN U, HOSSFELD DK. Stromal abnormalities in neoplastic bone marrow diseases. Ann Hematol 1996;73:53-70.
25. TAURO S, HEPBURN MD, PEDDIE CM, BOWEN DT, PIPPARD MJ. Functional disturbance of marrow stromal microenvironment in the myelodysplastic syndromes. Leukemia 2002;16:785-790.
26. DEEG HJ, BECKHAM C, LOKEN MR, BRYANT E, LESNIKOVA M, SHULMAN HM, GOOLEY T. Negative regulators of hemopoiesis and stroma function in patients with myelodysplastic syndrome. Leuk Lymphoma 2000;37: 405-414.
27. AIZAWA S, NAKANO M, IWASE O, YAGUCHI M, HIRAMOTO M, HOSHI H, NABESHIMA R, SHIMA D, HANDA H, TOYAMA K. Bone marrow stroma from refractory anemia of myelodysplastic syndrome is defective in its ability to support normal CD34-positive cell proliferation and differentiation in vitro. Leuk Res 1999;23:239-246.
28. GIDALI J, FEHER I, HOLLAN SR. Blast colony forming cell-binding capacity of bone marrow stroma from myelodysplastic patients. Stem Cells 1996;14:577-583.
29. TENNANT GB, WALSH V, TRURAN LN, EDWARDS P, MILLS KI, BURNETT AK. Abnormalities of adherent layers grown from bone marrow of patients with myelodysplasia. Br J Haematol 2000;111:853-862.
30. PARKER JE, SHAFI T, PAGLIUCA A, et al. Allogeneic stem cell transplantation in the myelodysplastic syndromes: interim results of outcome following reduced-intensity conditioning compared with standard preparative regimens. Br J Haematol 2002;119:144-154.
31. DUHRSEN U, KNIELING G, BEECKEN W, NEUMANN S, HOSSFELD DK. Chimaeric cultures of human marrow stroma and murine leukaemia cells: evidence for abnormalities in the haemopoietic microenvironment in myeloid malignancies and other infiltrating marrow disorders. Br J Haematol 1995;90:502-511.
32. ZHANG W, KNIELING G, VOHWINKEL G, MARTINEZ T, KUSE R, HOSSFELD DK, DUHRSEN U. Origin of stroma cells in long-term bone marrow cultures from patients with acute myeloid leukemia. Ann Hematol 1999;78:305-314.
33. WETZLER M, KURZROCK R, LOWE DG, KANTARJIAN H, GUTTERMAN JU, TALPAZ M. Alteration in bone marrow adherent layer growth factor expression: a novel mechanism of chronic myelogenous leukemia progression. Blood 1991;78:2400-2406.
34. NOTARO R, CIMMINO A, TABARINI D, ROTOLI B, LUZZATTO L. In vivo telomere dynamics of human hematopoietic stem cells. Proc Natl Acad Sci USA 1997;94:13782-13785.
35. AKIYAMA M, ASAI O, KURAISHI Y, et al. Shortening of telomeres in recipients of both autologous and allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplant 2000;25:441-447.