Role of nitric oxide in exercise sympatholysis

Journal of Applied Physiology

Volumn 97, Issue 1, 2004, Pages 417-423

  Buckwalter, John B ^a   Taylor, Jessica C ^a   Hamann, Jason J ^a   Clifford, Philip S ^a  

^a CLEMENT J ZABLOCKI VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Autonomic nervous system; Blood flow; Dogs; Vasoconstriction

Indexed keywords

ALPHA 1 ADRENERGIC RECEPTOR STIMULATING AGENT; ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; CLONIDINE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PHENYLEPHRINE;

ADRENERGIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERY CATHETERIZATION; ARTICLE; ATTENUATION; AUTONOMIC NERVOUS SYSTEM; BOLUS INJECTION; CONDUCTANCE; CONTROLLED STUDY; DOG; ENZYME INHIBITION; EXERCISE; FEMORAL ARTERY; HEMODYNAMICS; HINDLIMB; ILIAC ARTERY; MUSCLE CONTRACTION; NONHUMAN; PRIORITY JOURNAL; SKELETAL MUSCLE; VASCULAR CONDUCTANCE; VASOCONSTRICTION;

ADRENERGIC ALPHA-AGONISTS; ANIMALS; BLOOD PRESSURE; CLONIDINE; DOGS; ENZYME INHIBITORS; EXERTION; HEMODYNAMIC PROCESSES; HINDLIMB; MUSCLE, SKELETAL; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE I; PHENYLEPHRINE; RECEPTORS, ADRENERGIC, ALPHA-1; RECEPTORS, ADRENERGIC, ALPHA-2; REGIONAL BLOOD FLOW; REST; SYMPATHETIC NERVOUS SYSTEM; VASOCONSTRICTOR AGENTS; VASOPRESSINS;

EID: 3042662503     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/japplphysiol.01181.2003     Document Type: Article

References (37)

1. 2-adrenoceptor constriction to metabolic inhibition during rat skeletal muscle contraction. Circ Res 69: 174-184, 1991.
2. Buckwalter JB and Clifford PS. α-Adrenergic vasoconstriction in active skeletal muscles during dynamic exercise. Am J Physiol Heart Circ Physiol 277: H33-H39, 1999.
3. Buckwalter JB and Clifford PS. The paradox of sympathetic vasoconstriction in exercising skeletal muscle. Exerc Sport Sci Rev 29: 159-163, 2001.
4. Buckwalter JB, Mueller PJ, and Clifford PS. Autonomic control of skeletal muscle vasodilation during exercise. J Appl Physiol 83: 2037-2042, 1997.
5. Buckwalter JB, Mueller PJ, and Clifford PS. Sympathetic vasoconstriction in active skeletal muscles during dynamic exercise. J Appl Physiol 83: 1575-1580, 1997.
6. Buckwalter JB, Mueller PJ, and Clifford PS. α-Adrenergic receptor responsiveness in skeletal muscle during dynamic exercise. J Appl Physiol 85: 2277-2283, 1998.
7. Buckwalter JB, Naik JS, Valic Z, and Clifford PS. Exercise attenuates α-adrenergic-receptor responsiveness in skeletal muscle vasculature. J Appl Physiol 90: 172-178, 2001.
8. Buckwalter JB, Ruble SB, Mueller PJ, and Clifford PS. Skeletal muscle vasodilation at the onset of exercise. J Appl Physiol 85: 1649-1654, 1998.
9. Burcher E and Garlick D. Antagonism of vasoconstrictor responses by exercise in the gracilis muscle of the dog. J Pharmacol Exp Ther 187: 78-85, 1973.
10. Chavoshan B, Sander M, Sybert TE, Victor RG, and Thomas GD. Nitric oxide-dependent modulation of sympathetic vasoconstriction in the microvasculature of exercising human skeletal muscle. J Physiol 540: 377-386, 2002.
11. DiCario SE, Chen CY, and Collins HL. Onset of exercise increases lumbar sympathetic nerve activity in rats. Med Sci Sports Exerc 28: 677-684, 1996.
12. Dinenno FA and Joyner MJ. Blunted sympathetic vasoconstriction in contracting skeletal muscle of healthy humans: is nitric oxide obligatory? J Physiol 553: 281-292, 2003.
13. Drew GM and Whiting SB. Evidence for two distinct types of postsynaptic α adrenoceptor in vascular smooth muscle in vivo. Br J Pharmacol 67: 207-215, 1979.
14. Faber JE. In situ analysis of α-adrenoceptors on arteriolar and venular smooth muscle in rat skeletal muscle microcirculation. Circ Res 62: 37-50, 1988.
15. Hamed AT, Jandhyala BS, and Lokhandwala MF. Evaluation of the role of alpha-1 and alpha-2 adrenoceptors in the maintenance of neurogenic tone to the hindlimb vasculature. J Pharmacol Exp Ther 238: 599-605, 1986.
16. Joyner MJ, Nauss LA, Warner MA, and Warner DO. Sympathetic modulation of blood flow and 02 uptake in rhythmically contracting human forearm muscles. Am J Physiol Heart Circ Physiol 263: H1079-H1083, 1992.
17. 2-adrenergic receptors in neural vascular tone of canine skeletal muscle. Am J Physiol Heart Circ Physiol 262: H1705-H1710, 1992.
18. Lautt WW. Resistance or conductance for expression of arterial vascular tone. Microvasc Res 37: 230-236, 1989.
19. LeNoble JL, Struyker-Boudier HA, and Smits JF. Differential effects of general anesthetics on regional vasoconstrictor responses in the rat. Arch Int Pharmacodyn Ther 289: 82-92, 1987.
20. 2- adrenoceptors. Circ Res 66: 1643-1657, 1990.
21. 2-adrenoceptor constriction of rat skeletal muscle microvessels. Circ Res 69: 165-173, 1991.
22. 2-adrenoceptor-mediated vasoconstrictor responses in isolated arteries. Eur J Pharmacol 135: 443-447, 1987.
23. Meier MA and Long DM. Carotid artery loop for repeated catheterization of the left ventricle in dogs. Surgery 70: 797-799, 1971.
24. O'Brien DJ, Chapman WH, Rudd FV, and McRoberts JW. Carotid artery loop method of blood pressure measurement in the dog. J Appl Physiol 30: 161-163, 1971.
25. O'Leary DS. Regional vascular resistance vs. conductance: which index for baroreflex responses? Am J Physiol Heart Circ Physiol 260: H632-H637, 1991.
26. O'Leary DS, Robinson ED, and Butler JL. Is active skeletal muscle functionally vasoconstricted during dynamic exercise in conscious dogs? Am J Physiol Regul Integr Comp Physiol 272: R386-R391, 1997.
27. Peterson DF, Armstrong RB, and Laughlin MH. Sympathetic neural influences on muscle blood flow in rats during submaximal exercise. J Appl Physiol 65: 434-440, 1988.
28. Remensnyder JP, Mitchell JH, and Sarnoff SJ. Functional sympatholysis during muscular activity. Circ Res 11: 370-380, 1962.
29. Ruble SB, Valic Z, Buckwalter JB, and Clifford PS. Dynamic exercise attenuates sympathetic responsiveness of canine vascular smooth muscle. J Appl Physiol 89: 2294-2299, 2000.
30. Ruble SB, Valic Z, Buckwalter JB, Tschakovsky ME, and Clifford PS. Attenuated vascular responsiveness to norepinephrine release during dynamic exercise in dogs. J Physiol 541: 637-644, 2002.
31. Sanders M, Chavoshan B, Harris SA, Iannoccone ST, Stull JT, Thomas GD, and Victor RG. Functional muscle ischemia in neuronal nitric oxide synthase-deficient skeletal muscle of children with Duchenne muscular dystrophy. Proc Natl Acad Sci USA 97: 13818-13823, 2000.
32. 1-adrenoceptor constriction by acidosis and hypoxia in vitro, Am J Physiol Heart Circ Physiol 268: H2068-H2076, 1995,
33. 2- adrenergic vasoconstriction during contraction of glycolytic, not oxidative, rat hindlimb muscle. Am J Physiol Heart Circ Physiol 266: H920-H929, 1994.
34. Thomas GD, Sander M, Lau KS, Huang PL, Stull JT, and Victor RG. Impaired metabolic modulation of α-adrenergic vasoconstriction in dystophin-deficient skeletal muscle, Proc Natl Acad Sci USA 95: 15090-15095, 1998.
35. Thomas GD and Victor RG. Nitric oxide mediates contraction-induced attenuation of sympathetic vasoconstriction in rat skeletal muscle. J Physiol 506: 817-826, 1997.
36. Tschakovsky ME, Sujirattanawimol K, Ruble SB, Valic Z, and Joyner MJ. Is sympathetic neural vasoconstriction blunted in the vascular bed of exercising human muscle? J Physiol 541: 623-635, 2002.
37. Vatner SF, Franklin D, Van Citters RL, and Braunwald E. Effects of carotid sinus nerve stimulation on blood-flow distribution in conscious dogs at rest and during exercise. Circ Res 27: 495-503, 1970.