Endometrial safety with a low-dose intrauterine levonorgestrel-releasing system after 3 years of estrogen substitution therapy

Maturitas

Volumn 48, Issue 1, 2004, Pages 65-70

  Wildemeersch, D ^a   Schacht, E ^b   Wildemeersch, P ^c   Calleweart, K ^b   Pylyser, K ^d   De Wever, N ^d  

^a Gynecologische Dienst   (Belgium)

^b GHENT UNIVERSITY   (Belgium)

^c Gynecological Outpatient Clinic and IUD Training Center   (Belgium)

^d SINT AUGUSTINUS HOSPITAL   (Belgium)

Author keywords

Endometrial histology; Endometrial suppression; Hormone replacement therapy; Intrauterine drug delivery system (IUS); Levonorgestrel

Indexed keywords

ESTRADIOL; LEVONORGESTREL;

ADULT; AMENORRHEA; ARTICLE; ATROPHY; CELL PROLIFERATION; CLINICAL ARTICLE; CLINICAL TRIAL; DECIDUALIZATION; DRUG DELIVERY SYSTEM; DRUG RELEASE; ENDOMETRIUM; ENDOMETRIUM BIOPSY; ESTROGEN THERAPY; FEMALE; HISTOLOGY; HUMAN; HUMAN TISSUE; LONG TERM CARE; MENOPAUSAL SYNDROME; MENSTRUAL CYCLE; OUTCOMES RESEARCH; POSTMENOPAUSE; PROSPECTIVE STUDY; RISK ASSESSMENT; STROMA; TRANSVAGINAL ECHOGRAPHY; UTERUS BLEEDING;

AGED; ENDOMETRIUM; ESTRADIOL; ESTROGEN REPLACEMENT THERAPY; FEMALE; HUMANS; INTRAUTERINE DEVICES, MEDICATED; LEVONORGESTREL; MIDDLE AGED; POSTMENOPAUSE; PROSPECTIVE STUDIES; TREATMENT OUTCOME;

EID: 3042645965     PISSN: 03785122     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.maturitas.2003.07.002     Document Type: Article

References (27)

1. Wildemeersch D., Schacht E., Wildemeersch P. Performance and acceptability of intrauterine release of levonorgestrel with a miniature delivery system for hormonal substitution therapy, contraception and treatment in peri- and postmenopausal women. Maturitas. 44:2002;237-245
2. Wildemeersch D., Schacht E. Treatment of menorrhagia with a novel "frameless" intrauterine levonorgestrel-releasing drug delivery system: A pilot study. Eur. J. Contracept Reprod Health Care. 6:2001;93-101
3. Wildemeersch D., Schacht E. The effect on menstrual blood loss in women with uterine fibroids of a novel 'frameless' intrauterine levonorgestrel- releasing drug delivery system, a pilot study. Eur J Obst Gynecol Reprod Biol. 102(1):2001;74-79
4. Andrade GN, Andrade ATL, Souza JP, Wildemeeersch D. Estudo de perdas sanguínas com FibroPlant, novo sistema intrauterino de levonorgestrel e estoques de ferro orgânico-resultados iniciais. Presented at the XVIII Reunion de Associacion Latinamericana de Investigadores en Reproduccion Humana (ALIRH), Varadero, Cuba, 28-31 May 2003.
5. Wildemeersch D., Dhont M. Treatment of non atypical and atypical endometrial hyperplasia with a levonorgestrel-releasing intrauterine system. Am. J. Obstet. Gynecol. 138:2003;1297-1298
6. Wildemeersch D., Schacht E., Wildemeersch P. Contraception and treatment in the perimenopause with a novel "frameless" intrauterine levonorgestrel-releasing drug delivery system. Contraception. 66:2002;93-99
7. Janssens D., Wildemeersch D., Dhont M. Klinische resultaten met FibroPlant-LNG, een nieuw LNG IUS voor behandeling en anticonceptie. Gunaïkeia. 7:2002;154-158
8. Wildemeersch D., Schacht E. Endometrial suppression with a new "frameless" levonorgestrel releasing intrauterine system in perimenopausal and postmenopausal women: a pilot study. Maturitas. 36:2000;63-68
9. Fleischer AC, Kepple DM. Benign conditions of the uterus, cervix and endometrium. In: Nyberg DA, Hill LM, Böhm-Velez M, Mendelson EB, editors. Transvaginal ultrasound. St Louis: Mosby Year Book; 1992. p. 21-4.
10. Hendrickson MR, Kempson RL. Surgical pathology of the uterine corpus. In: Major problems in pathology, vol 12. London: Saunders; 1980. p. 99-158. ISBN 0-7216-4644-1.
11. Woodruff J.D., Pickar J.H. Incidence of endometrial hyperplasia in postmenopausal women taking conjugated estrogens (Premarin) with medroxyprogesterone acetate or conjugated estrogens alone. Am. J. Obstet. Gynecol. 170:1994;1213-1223
12. The Writing Group for the PEPI Trial. Effect of homone replacement therapy on endometrial hystology in postmenopausal women. J Am Med Assoc 1996;275:370-5.
13. Johannisson E., Holinka C.F., Arrenbrecht S. Transdermal sequential and continuous hormone replacement regimens with estradiol and norethisterone acetate in postmenopausal women. Int. J. Fert. 42(Suppl. 2):1997;288-298
14. Nilsson C.G., Luukainen T., Arco H. Endometrial morphology of women using a D-norgestrel-releasing intrauterine device. Fert. Steril. 29:1978;397-401
15. Silverberg S.G., Haukkamaa M., Arko H., Nilsson C.G., Luukkainen T. Endometrial morphology during long-term use of levonorgestrel-releasing intrauterine devices. Int. J. Gynecol. Pathol. 5:1986;235-241
16. Wollter-Svensson L.O., Stadberg E., Andersson K., Mattsson L.A., Odlind V., Persson I. Intrauterine administration of levonorgestrel in two low doses in HRT. A randomized clinical trial during one year, effects on lipid and lipoprotein metabolism. Maturitas. 22:1995;199-205
17. Raudaskoski T., Tapanainen J., Tomás E., Luotola H., Pekonen F., Ronni-Sivula H., et al. Intrauterine 10 and 20 μg levonorgestrel systems in postmenopausal women receiving oral oestrogen replacement therapy: clinical, endometrial and metabolic response. Br. J. Obstet. Gynecol. 109:2002;136-144
18. Andersson K., Mattsson L.A., Rybo G., Stadberg E. Intrauterine release of levonorgestrel - a new way of adding progestogen in hormone replacement therapy. Obstet Gynecol. 79:1992;963-967
19. Riphagen F.E. Intrauterine application of progestins in hormone replacement therapy: a review. Climacteris. 3:2000;199-211
20. Raudaskoski T.H., Lahti E.I., Kauppila A.J., Apaja-Sarkkinen M.A., Laatikainen T.J. Transdermal estrogen with levonorgestrel-releasing intrauterine device for climacteric complaints: clinical and endometrial responses. Am. J. Obstet. Gynecol. 172:1995;114-117
21. Suhonen S.P., Allonen H.O., Lähteenmäki P. Sustained-release estradiol implants and a levonorgestrel-releasing intrauterine device in hormone replacement therapy. Am. J. Obstset. Gynecol. 172:1995;562-567
22. Suhonen S.P., Allonen H.O., Lähteenmäki P. Three-year follow-up of the use of a levonorgestrel-releasing intrauterine system in hormone replacement therapy. Acta Obstet. Gynecol. Scand. 76:1997;145-150
23. Bain C, Kitchener HC. Post-menopausal bleeding. In: Cameron IT, Fraser IS, Smith SK, editors. Clinical disorders of the endometrium and menstrual cycle Oxford, UK: Oxford University Press; 1998. p. 266-78.
24. Fleischer A.C., Kalemeris G.C., Machin J.E., Entman S.S., James A.E. Sonographic depiction of normal and abnormal endometrium with histopathologic correlation. J. Ultrasound Med. Biol. 5:1986;445-452
25. Writing Group for the Women's Health Initiative Investigators. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial. JAMA 2002;288:321-33.
26. Li C.I., Malone K.E., Porter P.L., Weiss N.S., Tang M.-T.C., Cushing-Haugen K.L., et al. Relationship between long durations of hormone replacement therapy and risk of breast cancer. JAMA. 289:2003;3254-3263
27. Writing Group for the Women's Health Initiative Investigators. Influence of estrogen plus progestin on breast cancer and mammography in healthy postmenopausal women. The Women's Health Initiative randomized trial. JAMA 2002;289:2243-53.