Performance and acceptability of intrauterine release of levonorgestrel with a miniature delivery system for hormonal substitution therapy, contraception and treatment in peri and postmenopausal women

Maturitas

Volumn 44, Issue 3, 2003, Pages 237-245

  Wildemeersch, D ^a   Schacht, E ^b   Wildemeersch, P ^c  

^a Gynecologische Dienst   (Belgium)

^b GHENT UNIVERSITY   (Belgium)

^c Gynecological Outpatient Clinic and IUD Training Center   (Belgium)

Author keywords

Contraception; Hormone substitution therapy; Hyperplasia; Intrauterine drug delivery system (IUS); Levonorgestrel; Menorrhagia

Indexed keywords

ESTRADIOL; LEVONORGESTREL;

ADULT; AGED; AMENORRHEA; ARTICLE; BLEEDING; CLIMACTERIUM; CLINICAL TRIAL; CONTRACEPTION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG RELEASE; DRUG SAFETY; DRUG TOLERABILITY; ECHOGRAPHY; ENDOMETRIUM; FEMALE; FOLLOW UP; HORMONE SUBSTITUTION; HUMAN; MAJOR CLINICAL STUDY; MEDICAL ASSESSMENT; MENOPAUSAL SYNDROME; MENSTRUATION; POSTMENOPAUSE; PREGNANCY; PROSPECTIVE STUDY; SPOTTING;

EID: 0037470769     PISSN: 03785122     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5122(03)00046-X     Document Type: Article

References (41)

1. World Health Organization Scientific Group (WHO) 1996 Research on the Menopause in the 1990s. WHO Technical Services Report Series No. 866, Geneva: World Health Organization.
2. Nillson L. The hormonal situation in the perimenopausal period. Acta Obstet. Gynecol. Scand. Suppl 130:1985;9-11.
3. McKinlay S.M., Brambilla D.J., Posner J.G. The normal menopause transition. Maturitas. 14:1992;103-115.
4. Burger H.G. Pituitary and ovarian changes. Fraser I.S., Jansen R.P.S., Lobo R.A., Whitehead M.I. Estrogens and progestogens in clinical practice. 1998;627-634 Churchill Livingstone, London.
5. Bachman G.A. The change before the 'change': strategies for transition to the menopause. Postgrad. Med. 95:1994;113-124.
6. Santoro N., Rosenberg-Brown J., Adel T., Skurnick J.H. Characterization of reproductive hormonal dynamics in the perimenopause. J. Clin. Endocrinol. Metab. 81:1996;1495-1501.
7. Nesse R.E. Abnormal vaginal bleeding in perimenopausal women. Am. Fam. Phys. 40:1989;185-192.
8. Hallberg L., Högdahl A., Nillson L., Rybo G. Menstrual blood loss - a population study. Acta Obstet. Gynecol. Scand. 45:1966;330-351.
9. Rybo G. Population studies of menorrhagia. Res. Clin. Forums. 5:1983;77-81.
10. Henshaw S.K. Unintended pregnancy in the United States. Fam. Plann. Perspect. 30:1998;24-29.
11. Brzechffa P.R., Judd H.L. Hot flashes. Fraser I.S., Jansen R.P.S., Lobo R.A., Whitehead M.I. Estrogens and progestogens in clinical practice. 1998;635-645 Churchill Livingstone, London.
12. Whitehead M.I. General principles of administration of hormone replacement therapy: indications and contraindications, routes of administration, treatment schedules. Fraser I.S., Jansen R.P.S., Lobo R.A., Whitehead M.I. Estrogen and progestogens in clinical practice. 1998;667-686 Churchill Livingstone, London.
13. Furchgott R.F., Zawadski J.V. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acethylcholine. Nature. 288:1980;373-376.
14. Hulley S., Grady D., Bush T., Furberg C., Herrington D., Riggs B., Vittinghoff E. Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. J. Am. Med. Assoc. 280:1998;605-613.
15. Andersson K., Mattsson L.A., Rybo G., Stadberg E. Intrauterine release of levonorgestrel - a new way of adding progestogen in hormone replacement therapy. Obstet. Gynecol. 79:1992;963-967.
16. Raudaskoski T.H., Lahti E.I., Kauppila A.J., Apaja-Sarkkinen M.A., Laatikainen T.J. Transdermal estrogen with levonorgestrel-releasing intrauterine device for climacteric complaints: clinical and endometrial responses. Am. J. Obstet. Gynecol. 172:1995;114-117.
17. Suhonen S.P., Allonen H.O., Lähteenmäki P. Sustained-release estradiol implants and a levonorgestrel-releasing intrauterine device in hormone replacement therapy. Am. J. Obstset. Gynecol. 172:1995;562-567.
18. Suhonen S.P., Allonen H.O., Lähteenmäki P. Three-year follow-up of the use of a levonorgestrel-releasing intrauterine system in hormone replacement therapy. Acta Obstet. Gynecol. Scand. 76:1997;145-150.
19. Boon J. The LNG intrauterine system as part of continuous combined HRT in perimenopausal women. Dissertation, University Utrecht, Faculty of Medicine, The Netherlands, 1998.
20. Birkhaüser M.H. New routes of HRT administration. Int. J. Fertil. 43:1998;206-207.
21. Wildemeersch D., Schacht E. Endometrial suppression with a new 'frameless' levonorgestrel releasing intrauterine system in perimenopausal and postmenopausal women: a pilot study. Maturitas. 36:2000;63-68.
22. Wildemeersch D. Development of a miniature, frameless intrauterine levonorgestrel-releasing intrauterine system for contraception and treatment: a review of clinical experience. Reprod. BioMed. 4:2002;69-80.
23. Fleischer A.C., Kepple D.M. Benign conditions of the uterus, cervix and endometrium. Nyberg D.A., Hill L.M., Böhm-Velez M., Mendelson E.B. Transvaginal ultrasound. 1992;21-24 Mosby Year Book, St. Louis.
24. SAS Institute Inc. SAS user's guide: basics, version 5 edition. Cary, NC: SAS Institute Inc., 1985.
25. Tietze C., Lewit S. Recommended procedures for the statistical evaluation of intrauterine contraception. Stud. Fam. Plann. 4:1972;35-42.
26. Farley T.M.M. Life-table methods for contraceptive research. Stat. Med. 5:1986;475-489.
27. Hammond C.B. Women's concerns with hormone replacement therapy-compliance issues. Fertil. Steril. 62S2:1994;157S-160S.
28. Hill D.A., Weiss N.S., La Croix A.Z. Adherance to postmenopausal hormone therapy during the year after the initial prescription: a population-based study. Am. J. Obstet. Gynecol. 182:2000;270-276.
29. Castelo-Branco C., Figueras F., Sanjuan A., Vincente J.J., Martinez de Osaba M.J., Pons F., Balasch J., vanrell J.A. Long-term compliance with estrogen replacement therapy in surgical postmenopausal women: benefits to bone and analysis of factors associated with discontinuation. J. North Am. Menopause Soc. 6:1999;307-311.
30. Ettinger B., Pressman A., Silver P. Effec of age on reasons for iniation and discontinuation of hormone replacement therapy. J. North Am. Menopause Soc. 6:1999;282-289.
31. Magoo A.L., Brincat M., Studd J.W.W., Wardle P., Schlesinger P., O'Dowd T. Amenorrhoea and endometrial atrophy with continuous oral estrogen and progestogen therapy in postmenopausal women. Obstet. Gynecol. 65:1985;496-499.
32. Cerin A., Heldaas K., Moeller B. Adverse endometrial effects of long-cycle estrogen and progestogen replacement therapy. New Engl. J. Med. 334:1996;668-669.
33. Whitehead M.I., Hillard T.C., Crook D. The role of progestogens. Obstet. Gynecol. 75:1990;29S-76S.
34. Silverberg S.G., Haukkamaa M., Arko H., Nilsson C.G., Luukkainen T. Endometrial morphology during long-term use of levonorgestrel-releasing intrauterine devices. Int. J. Gynecol. Path. 5:1986;235-241.
35. Smith S.K. The pathophysiology of menstruation. Cameron I.T., Fraser I.S., Smith S.K. Clinical disorders of the endometrium and the menstrual cycle. 1998;105-115 Oxford University Press, Oxford.
36. Voda A.M., Kernoff Mansfield P., Root J.L. Menstruation, surgery, and women. Cameron I.T., Fraser I.S., Smith S.K. Clinical disorders of the endometrium and the menstrual cycle. 1998;67-85 Oxford University Press, Oxford.
37. Wildemeersch D., Schacht E., Wildemeersch P. Treatment of hyperplasia with a new 'frameless' levonorgestrel releasing intrauterine system: a pilot study. Maturitas. 36:2000;63-68.
38. Perino A., Quartararo P., Catinella E., Genova G., Cittadini E. Treatment of endometrial hyperplasia with levonorgestrel releasing intrauterine devices. Acta Europaea Fertilitatis. 18:1987;137-140.
39. Scarcelli G., Tantini C., Colafranceschi M., Taddei G.L., Bargelli G., Venurini N., Branconi F. Levonorgestrel-Nova-T and precancerous lesions of the endometrium. Eur. J. Gynaecol. Oncol. 9:1988;284-286.
40. Fleischer A.C., Kalemeris G.C., Machin J.E., Entman S.S., James A.E. Sonographic depiction of normal and abnormal endometrium with histopathologic correlation. J. Ultrasound Med. 5:1986;445-452.
41. Grimes D. Contraception for women in the perimenopause In The Contraception Report 2001;2001:4-12.