Comparative analysis of ATP-binding cassette (ABC) transporter gene expression levels in peripheral blood leukocytes and in liver with hepatocellular carcinoma

Cancer Science

Volumn 95, Issue 6, 2004, Pages 530-536

  Moustafa, Mohsen A ^a,e   Ogino, Daisuke ^a   Nishimura, Masuhiro ^b   Ueda, Nobuhiko ^b   Naito, Shinsaku ^b   Furukawa, Motonobu ^a   Uchida, Takafumi ^a   Ikai, Iwao ^c   Sawada, Hideki ^d   Fukumoto, Manabu ^a  

^a TOHOKU UNIVERSITY   (Japan)

^b OTSUKA PHARMACEUTICAL CO LTD   (Japan)

^c KYOTO UNIVERSITY   (Japan)

^d YAMAGATA UNIVERSITY   (Japan)

^e Assiut Branch   (Egypt)

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER; ABC TRANSPORTER A1; ANTINEOPLASTIC AGENT; BILE ACID; CARRIER PROTEIN; LIPID; PROTEIN A2; PROTEIN B1; PROTEIN B2; PROTEIN B3; PROTEIN B4; PROTEIN C1; PROTEIN C5; PROTEIN G1; PROTEIN G2; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; BILE ACID SYNTHESIS; CANCER RESISTANCE; CELL LEVEL; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE MARKER; DRUG CHOICE; DRUG PROTEIN BINDING; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; LEUKOCYTE; LIPID METABOLISM; LIVER CELL CARCINOMA; LIVER LEVEL; MALE; MONITORING; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FAMILY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADULT; AGED; ATP-BINDING CASSETTE TRANSPORTERS; CARCINOMA, HEPATOCELLULAR; CLUSTER ANALYSIS; FEMALE; GENE EXPRESSION; HUMANS; LEUKOCYTES, MONONUCLEAR; LIVER; LIVER NEOPLASMS; MALE; MIDDLE AGED;

EID: 3042633767     PISSN: 13479032     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2004.tb03244.x     Document Type: Article

References (27)

1. Higgins CF. ABC transporters: from microorganisms to man. Annu Rev Cell Biol 1992; 8: 67-113.
2. Childs S, Ling V. The MDR superfamily of genes and its biological implications. Important Adv Oncol 1994; 21-36.
3. Dean M, Allikmets R. Complete characterization of the human ABC gene family. J Bioenerg Biomembr 2001; 33: 475-9.
4. Gottesman MM, Ambudkar SV. Overview: ABC transporters and human disease. J Bioenerg Biomembr 2001; 33: 453-8.
5. Borst P, Elferink RO. Mammalian ABC transporters in health and disease. Annu Rev Biochem 2002; 71: 537-92.
6. Trauner M, Boyer JL. Bile salt transporters: molecular characterization, function, and regulation. Physiol Rev 2003; 83: 633-71.
7. Faber KN, Muller M, Jansen PL. Drug transport proteins in the liver. Adv Drug Deliv Rev 2003; 55: 107-24.
8. Cherrington NJ, Hartley DP, Li N, Johnson DR, Klaassen CD. Organ distribution of multidrug resistance proteins 1, 2, and 3 (Mrp1, 2, and 3) mRNA and hepatic induction of Mrp3 by constitutive androstane receptor activators in rats. J Pharmacol Exp Ther 2002; 300: 97-104.
9. Klucken J, Buehler JC, Orso E, Kaminski WE, Porsch-Ozcurumez M, Liebisch G, Kapinsky M, Diederich W, Drobnik W, Dean M, Allikmets R, Schmitz G. ABCG1 (ABC8), the human homolog of the Drosophila white gene, is a regulator of macrophage cholesterol and phospholipid transport. Proc Natl Acad Sci USA 2000; 97: 817-22.
10. van Eck M, Bos IS, Kaminski WE, Orso E, Rothe G, Twisk J, Bouttcher A, Van Amersfoort ES, Christiansen-Weber TA, Fung-Leung WP, Van Berkel TJ, Schmitz G. Leukocyte ABCA1 controls susceptibility to atherosclerosis and macrophage recruitment into tissues. Proc Natl Acad Sci USA 2002; 99: 6298-303.
11. Nishimura M, Yoshitsugu H, Naito S, Hiraoka I. Evaluation of gene induction of drug-metabolizing enzymes and transporters in primary culture of human hepatocytes using high-sensitivity real-time reverse transcription PCR. Yakugaku Zasshi 2002; 122: 339-61.
12. Lecureur V, Courtois A, Payen L, Verhnet L, Guillouzo A, Fardel O. Expression and regulation of hepatic drug and bile acid transporters. Toxicology 2000; 153: 203-19.
13. Hooiveld GJ, van Montfoort JE, Meijer DK, Muller M. Function and regulation of ATP-binding cassette transport proteins involved in hepatobiliary transport. Eur J Pharm Sci 200 1; 12: 525-43.
14. Brewer HB, Santamarina-Fojo S. Clinical significance of high-density lipoproteins and the development of atherosclerosis: focus on the role of the adenosine triphosphate-binding cassette protein A1 transporter. Am J Cardiol 2003; 92: 10-6.
15. Langmann T, Mauerer R, Zahn A, Moehle C, Probst M, Stremmel W, Schmitz G. Real-time reverse transcription-PCR expression profiling of the complete human ATP-binding cassette transporter superfamily in various tissues. Clin Chem 2003; 49: 230-8.
16. Zhou S, Schuetz JD, Buntin KD, Colapietro AM, Sampath J, Morris JJ, Lagutina I, Grosveld GC, Osawa M, Nakauchi H, Sorrentino BP. The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype. Nat Med 2001; 7: 1028-34.
17. Schmitz G, Langmann T, Heimerl S. Role of ABCG1 and other ABCG family members in lipid metabolism. J Lipid Res 2001; 42: 1513-20.
18. Doyle LA, Yang W, Abruzzo LV, Krogmann T, Gao Y, Rishi AK, Ross DD. A multidrug resistance transporter from human MCF-7 breast cancer cells. Proc Natl Acad Sci USA 1998; 95: 15665-70.
19. Diestra JE, Scheffer GL, Catala I, Maliepaard M, Schellens JH, Schepe, RJ, Germa-Lluch JR, Izquierdo MA. Frequent expression of the multi-drug resistance-associated protein BCRP/MXR/ABCP/ABCG2 in human tumours detected by the BXP-21 monoclonal antibody in paraffin-embedded material. J Pathol 2002; 198: 213-9.
20. Lankat-Buttgereit B, Tampe R. The transporter associated with antigen processing: function and implications in human diseases. Physiol Rev 2002; 82: 187-204.
21. Giorda E, Sibilio L, Martayan A, Moretti S, Venturo I, Mottolese M, Ferrara GB, Cappellacci S, Eibenschutz L, Catricala C, Grammatico P, Giacomini P. The antigen processing machinery of class I human leukocyte antigens: linked patterns of gene expression in neoplastic cells. Cancer Res 2003; 63: 4119-27.
22. Ros JE, Libbrecht L, Geuken M, Jansen PL, Roskams TA. High expression of MDR1, MRP1, and MRP3 in the hepatic progenitor cell compartment and hepatocytes in severe human liver disease. J Pathol 2003; 200: 553-60.
23. Gerk PM, Vote M. Regulation of expression of the multidrug resistance-associated protein 2 (MRP2) and its role in drug disposition. J Pharmacol Exp Ther 2002; 302: 407-15.
24. Hinoshita E, Taguchi K, Inokuchi A, Uchiumi T, Kinukawa N, Shimada M, Tsuneyoshi M, Sugimachi K, Kuwano M. Decreased expression of an ATP-binding cassette transporter, MRP2, in human livers with hepatitis C virus infection. J Hepatol 2001; 35: 765-73.
25. Zhou C, Zhao L, Inagaki N, Guan J, Nakajo S, Hirabayashi T, Kikuyama S, Shioda S. ATP-binding cassette transporter ABC2/ABCA2 in the rat brain: a novel mammalian lysosome-associated membrane protein and a specific marker for oligodendrocytes but not for myelin sheaths. J Neurosci 2001; 21: 849-57.
26. Laing NM, Belinsky MG, Kruh GD, Bell DW, Boyd JT, Barone L, Testa JR, Tew KD. Amplification of the ATP-binding cassette 2 transporter gene is functionally linked with enhanced efflux of estramustine in ovarian carcinoma cells. Cancer Res 1998; 58: 1332-7.
27. Kaminski WE, Piehler A, Pullmann K, Porsch-Ozcurumez M, Duong C, Bared GM, Buchler C, Schmitz G. Complete coding sequence, promoter region, and genomic structure of the human ABCA2 gene and evidence for sterol-dependent regulation of macrophages. Biochem Biophys Res Commun 2001; 281: 249-58.