Direct measurement of BDP and 17-BMP in bronchial and peripheral lung tissue after inhalation of HFA- vs CFC-driven aerosols

Pulmonary Pharmacology and Therapeutics

Volumn 17, Issue 4, 2004, Pages 233-238

  Holz, O ^a   Zuhlke I ^b   Einhaus, M ^a   Welker, L ^a   Kanniess, F ^b   Branscheid, D ^a   Nakashima, M ^a   Harrison, L I ^c   Jorres R A ^a,b   Richter, K ^b   Magnussen, H ^a,b  

^a KRANKENHAUS GROSSHANSDORF   (Germany)

^b Pulmonary Research Institute   (Germany)

^c 3M COMPANY   (United States)

Author keywords

Asthma therapy; Beclomethasone dipropionate; Extrafine aerosol; Inhaled corticosteroid; Lung deposition

Indexed keywords

AEROBEC; BECLOMETASONE DIPROPIONATE; BECLOMETHASONE 17 MONOPROPIONATE; CHLOROFLUOROCARBON; DRUG METABOLITE; NORFLURANE; UNCLASSIFIED DRUG; VENTOLAIR;

ADULT; AEROSOL; AGED; AIRWAY; ANALYTIC METHOD; ARTICLE; BLOOD SAMPLING; BRONCHUS; CLINICAL ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG FORMULATION; DRUG TISSUE LEVEL; FEMALE; HUMAN; HUMAN TISSUE; INHALATION; INTRAOPERATIVE PERIOD; LUNG CARCINOMA; LUNG PARENCHYMA; MALE; MOUTHWASH; POSTOPERATIVE PERIOD; PREOPERATIVE PERIOD; PRIORITY JOURNAL; SERUM; STATISTICAL SIGNIFICANCE; SURGICAL TECHNIQUE; TISSUE DISTRIBUTION;

ADMINISTRATION, INHALATION; ADULT; AEROSOL PROPELLANTS; AGED; BECLOMETHASONE; BRONCHI; CHLOROFLUOROCARBONS; DRUG CARRIERS; FEMALE; GLUCOCORTICOIDS; HUMANS; HYDROCARBONS, FLUORINATED; LUNG; MALE; MIDDLE AGED; PARTICLE SIZE; TIME FACTORS; TISSUE DISTRIBUTION;

EID: 3042578998     PISSN: 10945539     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pupt.2004.04.004     Document Type: Article

References (12)

1. Lipworth B.J. New perspectives on inhaled drug delivery and systemic bioactivity. Thorax. 50:1995;105-110
2. National Heart, Lung, and Blood Institute, National Institute of Health. Global Initiative for Asthma. Global strategy for asthma management and prevention. NHLBI/WHO Workshop report. National Institutes of Health Publication 1995; 95-3659.
3. Partridge M.R. Metered-dose inhalers and CFCs: what respiratory physicians need to know. Respir Med. 88:1994;645-647
4. Leach C.L., Davidson P.J., Boudreau R.J. Improved airway targeting with the CFC-free HFA-beclomethasone metered-dose inhaler compared with CFC-beclomethasone. Eur Respir J. 12:1998;1346-1353
5. Ferron S., Bourg S., Plante G., Beaudry F. Ultra trace analysis of beclomethasone dipropionate and its metabolites in human plasma using high performance liquid chromatographic mass spectrophotometric method. AAPS Pharm Sci. 3:2001;3
6. Harrison L.I., Soria I., Cline A.C., Ekholm B.P. Pharmacokinetic differences between chlorofluorocarbon and chlorofluorocarbon-free metered dose inhalers of beclomethasone dipropionate in adult asthmatics. J Pharm Pharmacol. 51:1999;1235-1240
7. Agertoft L., Laulund W.L., Harrison L.I., Pedersen S. The influence of particle size on lung deposition and pharmacokinetics of beclomethason dipropionate in children. Pediatr Pulmonol. 35:2003;192-199
8. Seale J.P., Harrison L.I. Effect of changing the fine particle mass of inhaled beclomethasone dipropionate on intrapulmonary deposition and pharmacokinetics. Respir Med. 92:1998;9-15
9. Esmailpour N., Hogger P., Rabe K.F., Heitmann U., Nakashima M., Rohdewald P. Distribution of inhaled fluticasone propionate between human lung tissue and serum in vivo. Eur Respir J. 10:1997;1496-1499
10. Marshall B.G., Wangoo A., Wagner C., Harrison L.I., Shaw R.J. Concentration of beclomethasone monopropionate in bronchoalveolar lavage fluid differed following two inhaled preparations of beclomethasone dipropionate. Am J Respir Crit Care Med. 159:1999;A116
11. Foe K., Brown K.F., Seale J.P. Comparative kinetics of metabolism of beclomethasone esters in human lung homogenates and plasma. J Pharm Sci. 89:2000;1143-1150
12. Harrison L.I., Kurup S., Wagner C., Ekholm B.P., Larson J.S., Kaiser H.B. Pharmacokinetics of beclomethasone 17-monopropionate from a beclomethasone dipropionate extrafine aerosol in adults with asthma. Eur J Clin Pharmacol. 58:2002;197-201