Childhood acute myeloid leukemia with CBFβ-MYH11 rearrangement: Study of incidence, morphology, cytogenetics, and clinical outcomes of Chinese in Hong Kong

American Journal of Hematology

Volumn 76, Issue 3, 2004, Pages 300-303

  Chan, Natalie P H ^a   Wong, W S ^a   Ng, Margaret H L ^a,b   Tsang, K S ^a   Lau, T T ^a   Leung, Yonna ^a   Chik, K W ^a   Shing, Mathew M K ^a   Li, C K ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

AML; CBF MYH11; Children; Chinese; FAB; Inv(16)

Indexed keywords

ANTINEOPLASTIC AGENT; CORE BINDING FACTOR; CORE BINDING FACTOR BETA; MYOSIN HEAVY CHAIN; UNCLASSIFIED DRUG;

ACUTE GRANULOCYTIC LEUKEMIA; ADOLESCENT; ARTICLE; CANCER CHEMOTHERAPY; CANCER RECURRENCE; CASE REPORT; CBFBETA GENE; CHILD; CHILDHOOD LEUKEMIA; CHINESE; CHROMOSOME G BAND; CLINICAL FEATURE; CORD BLOOD STEM CELL TRANSPLANTATION; CYTOGENETICS; DISEASE COURSE; EOSINOPHILIA; FEMALE; FUSION GENE; GENE; GENE REARRANGEMENT; GENE STRUCTURE; HISTOPATHOLOGY; HONG KONG; HUMAN; INFANT; LEUKEMIA REMISSION; MALE; MYH11 GENE; PRIORITY JOURNAL;

ADOLESCENT; BONE MARROW; CHILD; CHILD, PRESCHOOL; CHROMOSOME ABERRATIONS; CHROMOSOMES, HUMAN, PAIR 16; DNA-BINDING PROTEINS; FEMALE; HUMANS; INFANT; LEUKEMIA, MYELOCYTIC, ACUTE; MALE; MYOSIN HEAVY CHAINS; RECURRENCE; REMISSION INDUCTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SURVIVAL RATE; TRANSCRIPTION FACTOR AP-2; TRANSCRIPTION FACTORS;

EID: 3042542951     PISSN: 03618609     EISSN: None     Source Type: Journal    
DOI: 10.1002/ajh.20081     Document Type: Article

References (10)

1. Grimwade D, Walker H, Oliver F, et al., on behalf of the Medical Research Council Adult and Children's Leukaemia Working Parties. The importance of diagnostic cytogenetics on outcome in AML: analysis of 1,612 patients entered into the MRC AML 10 trial. Blood 1998;92:2322-2333.
2. Chang M, Raimondi SC, Ravingranath Y, et al. Prognostic factors in children and adolescents with acute myeloid leukemia (excluding children with Down syndrome and acute promyelocytic leukemia): univariate and recursive partitioning analysis of patients treated on Pediatric Oncology Group (POG) Study 8821. Leukemia 2000;14: 1201-1207.
3. Ng MH, Wong N, Tsang KS, Cheng SH, Chung YF, Lo KW. Recurrent chromosomal rearrangements involving breakpoints 3p21 and 19q13 in Chinese IgD multiple myeloma detected by G-banding and multicolor spectral karyotyping: a review of IgD karyotype literature. Hum Pathol 2001;32:1016-1020.
4. van Dongen JJ, Macintyre EA, Gabert JA, et al. Standardized RT-PCR analysis of fusion gene transcripts from chromosome aberrations in acute leukaemia for detection of minimal residual disease. Report of the BIOMED-1 Concerted Action: investigation of minimal residual disease in acute leukaemia. Leukemia 1999;13: 1901-1928.
5. Raimondi SC, Chang MN, Ravindranath Y, et al., for the Pediatric Oncology Group. Chromosomal abnormalities in 478 children with acute myeloid leukemia: clinical characteristic and treatment outcome in a cooperative pediatric oncology group study-POG 8821. Blood 1999;94:3707-3716.
6. Yang CP, Wu JH, Hung IJ, Jaing TH. Cytogenetic pattern of childhood leukemia in Taiwan. J Formos Med Assoc 2000;99:281-289.
7. Mitterbauer M, Laezika K, Novak M, et al. High concordance of karyotype analysis and RT-PCR for CBFβ/MYH11 in unselected patients with acute myeloid leukemia. A single center study. Am J Clin Pathol 2000;113:406-410.
8. Razzouk BI, Raimondi SC, Srivastava DK, et al. Impact of treatment on the outcome of acute myeloid leukemia with inversion 16: a single institution's experience. Leukemia 2001;15:1326-1330.
9. Hall GW. Childhood myeloid leukemias. Best Pract Res Clin Haematol 2001;3:573-591.
10. Poirel H, Radford-Weiss I, Rack K, et al. Detection of the chromosome 16 CBFβ-MYH11 fusion transcript in myelomonocytic leukemias. Blood 1995;85:1313-1322.