Reactions of Nifurtimox with critical sulfhydryl-containing biomolecules: Their potential toxicology relevance

Journal of Applied Toxicology

Volumn 24, Issue 3, 2004, Pages 189-195

  Diaz E G ^a   de Mecca, M Montalto ^a   Castro, José A ^a  

^a Instituto de Investigaciones Cientificas y Tecnicas de Las Fuerzas Armadas   (Argentina)

Author keywords

Adverse effects; Chagas's disease; Chemotherapeutic effects; Nifurtimox; Nitrite anion; Sulfhydryl compounds

Indexed keywords

COENZYME A; CYSTEINE; GLUTATHIONE; GLUTATHIONE TRANSFERASE; NIFURTIMOX; NITRITE; THIOCTIC ACID; THIOL DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CHAGAS DISEASE; CHEMICAL REACTION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DOSE RESPONSE; DRUG DETOXIFICATION; DRUG EFFECT; DRUG EXCRETION; DRUG STRUCTURE; DRUG TRANSFORMATION; DRUG URINE LEVEL; DRUG USE; DRUG WITHDRAWAL; ENDEMIC DISEASE; ENZYME ACTIVITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VIVO STUDY; LIVER CYTOSOL; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SOUTH AND CENTRAL AMERICA; TOXICOLOGY; TRYPANOSOMA CRUZI; URINALYSIS;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG INTERACTIONS; LIVER; MALE; NIFURTIMOX; NITRITES; RATS; RATS, SPRAGUE-DAWLEY; SULFHYDRYL COMPOUNDS;

TRYPANOSOMA; TRYPANOSOMA CRUZI;

EID: 3042536015     PISSN: 0260437X     EISSN: None     Source Type: Journal    
DOI: 10.1002/jat.970     Document Type: Article

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