A novel radioligand for imaging the AT1 angiotensin receptor with PET

Nuclear Medicine and Biology

Volumn 31, Issue 5, 2004, Pages 571-574

  Mathews, William B ^a   Yoo, Sung Eun ^b   Lee, Sung Hou ^b,c   Scheffel, Ursula ^a   Rauseo, Paige A ^a   Zober, Tamas G ^a   Gocco, Gerard ^a   Sandberg, Kathryn ^c   Ravert, Hayden T ^a   Dannals, Robert F ^a   Szabo, Zsolt ^a  

^a DEPARTMENT OF PATHOLOGY   (United States)

^b Korea Research Institute of Chemical Technology   (South Korea)

^c GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Angiotensin; AT1; Hypertension; KR31173; Mice; PET

Indexed keywords

2 BUTYL 5 METHOXYMETHYL 6 (1 OXOPYRIDIN 2 YL) 3 [[2' (1H TETRAZOL 5 YL)BIPHENYL 4 YL]METHYL] 3H IMIDAZO[4,5 B]PYRIDINE C 11; ANGIOTENSIN RECEPTOR; KR 31173; METHYL IODIDE; N [[4' [(2 ETHYL 5,7 DIMETHYL 3H IMIDAZO[4,5 B]PYRIDIN 3 YL)METHYL] 2 BIPHENYLYL]SULFONYL]BENZAMIDE; RADIOPHARMACEUTICAL AGENT; TETRAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ADRENAL GLAND; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HEART; HYDROLYSIS; ISOTOPE LABELING; KIDNEY; LUNG; MALE; MOUSE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY;

ADRENAL GLANDS; ANIMALS; CARBON RADIOISOTOPES; IMIDAZOLES; KIDNEY; LIGANDS; LIVER; MALE; MICE; ORGAN SPECIFICITY; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; RECEPTOR, ANGIOTENSIN, TYPE 1; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TETRAZOLES; TISSUE DISTRIBUTION;

EID: 3042532469     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nucmedbio.2003.10.014     Document Type: Article

References (15)

1. Cody R.J. Conceptual and therapeutic approaches to inhibition of the renin-angiotensin system in chronic heart failure. J Cardiovasc Pharmacol. 8:(suppl 1):1986;S58-S65
2. Williams G.H. Converting-enzyme inhibitors in the treatment of hypertension. N Engl J Med. 319:1988;1517-1525
3. Coulter D.M., Edwards I.R. Cough associated with captopril and enalapril. Br Med J. 294:1987;1521-1523
4. Gravas H., Gravas I. Angiotensin converting enzyme inhibitors properties and side effects. Hypertension. 11:(suppl II):1988;II37-II41
5. Roberts J.R., Wuerz R.C. Clinical characteristics of angiotensin- converting enzyme inhibitor-induced angioedema. Ann Emerg Med. 20:1991;555-558
6. Timmermans P.B., Smith R.D. Angiotensin II receptor subtypes selective antagonists and functional correlates. Eur Heart J. 15:(suppl D):1994;79-87
7. Wienen W., Mauz A.B., Van Meel J.C., Entzeroth M. Different types of receptor interaction of peptide and nonpeptide angiotensin II antagonists revealed by receptor binding and functional studies. Mol Pharmacol. 41:1992;1081-1088
8. Wong P.C., Price W.A. Jr, Chiu A.T., Duncia J.V., Carini D.J., Wexler R.R., Johnson A.L., Timmermans P.B. In vivo pharmacology of DuP 753. Am J Hypertens. 4:1991;288S-298S
9. Mathews W.B., Burns H.D., Dannals R.F., Ravert H.T., Naylor E.M. Carbon-11 labeling of the potent nonpeptide angiotensin-II antagonist MK-996. J Label Compds Radiopharm. 36:1995;729-737
10. Hamill T.G., Burns H.D., Dannals R.F., Mathews W.B., Musachio J.L., Ravert H.T., Naylor E.M. Development of [11C] L-159, 884 a radiolabelled, nonpeptide angiotensin II antagonist that is useful for angiotensin II, AT1 receptor imaging. Appl Radiat Isot. 47:1996;211-218
11. Kim S.E., Scheffel U., Szabo Z., Burns H.D., Gibson R.E., Ravert H.T., Mathews W.B., Hamill T.G., Dannals R.F. In vivo labeling of angiotensin II receptors with a carbon-11-labeled selective nonpeptide antagonist. J Nucl Med. 37:1996;307-311
12. Szabo Z., Kao P.F., Burns H.D., Gibson R.E., Hamill T.G., Ravert H.T., Kim S.E., Mathews W.B., Musachio J.L., Scheffel U., Dannals R.F. Investigation of angiotensin II/ AT1 receptors with carbon-11 L-159, 884 a selective AT1 antagonist. J Nucl Med. 39:1998;1209-1213
13. Szabo Z., Speth R.C., Brown P.R., Kerenyi L., Kao P.F., Mathews W.B., Ravert H.T., Hilton J., Rauseo P., Dannals R.F., Zheng W., Lee S., Sandberg K. Use of positron emission tomography to study AT1 receptor regulation in vivo. J Am Soc Nephrol. 12:2001;1350-1358
14. Lee S.H., Jung Y.S., Lee B.H., Yun S.I., Yoo S.E., Shin H.S. Characterization of angiotensin II antagonism displayed by SK-1080, a novel nonpeptide AT1-receptor antagonist. J Cardiovasc Pharmacol. 33:1999;367-374
15. Chang R.S., Lotti V.J. Angiotensin receptor subtypes in rat, rabbit and monkey tissues relative distribution and species dependency. Life Sci. 49:1991;1485-1490