Endothelium- and nitric oxide-dependent vasorelaxing activities of gamma-butyrobetaine esters: Possible link to the antiischemic activities of mildronate

European Journal of Pharmacology

Volumn 495, Issue 1, 2004, Pages 67-73

  Sjakste, Nikolajs ^a,b   Kleschyov, Andrei L ^c   Boucher, Jean Luc ^d   Baumane, Larisa ^b   Dzintare, Maija ^b   Meirena, Dainuvite ^b   Sjakste, Jelizaveta ^a,b   Sydow, Karsten ^c   Münzel, Thomas ^c   Kalvinsh, Ivars ^b  

^a UNIVERSITY OF LATVIA   (Latvia)

^b LATVIAN INSTITUTE OF ORGANIC SYNTHESIS   (Latvia)

^c UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^d UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

butyrobetaine; butyrobetaine ester; Mildronate; Nitric oxide synthase; NO (Nitric oxide); Vasorelaxation

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; GAMMA BUTYROBETAINE; GAMMA BUTYROBETAINE METHYL ESTER; MILDRONATE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; UNCLASSIFIED DRUG; VASODILATOR AGENT;

ANIMAL TISSUE; ARTICLE; BLOOD LEVEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVE SITE; ENZYME ACTIVITY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; TISSUE LEVEL; VASCULAR ENDOTHELIUM; VASODILATATION;

ANIMALS; AORTA, THORACIC; BETAINE; CARNITINE; DITIOCARB; DRUG COMBINATIONS; DRUG EVALUATION, PRECLINICAL; DRUG SYNERGISM; ELECTRON SPIN RESONANCE SPECTROSCOPY; ENDOTHELIUM; MALE; METHYLHYDRAZINES; MUSCLE, SMOOTH, VASCULAR; MYOCARDIAL ISCHEMIA; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE III; RATS; RATS, WISTAR; VASODILATION;

EID: 3042523841     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2004.05.006     Document Type: Article

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