The effects of ecstasy (MDMA) on rat liver bioenergetics

Academic Emergency Medicine

Volumn 11, Issue 7, 2004, Pages 723-729

  Rusyniak, Daniel E ^a,c   Tandy, Stephany L ^a   Kamendulis, Lisa M ^a   Sprague, Jon E ^b   Klaunig, James E ^a  

^a INDIANA UNIVERSITY   (United States)

^b OHIO NORTHERN UNIVERSITY   (United States)

^c REGENSTRIEF INSTITUTE   (United States)

Author keywords

3,4 methylenedioxymethamphetamine; amphetamines; liver; mitochondria; oxidative phosphorylation; uncoupling agents

Indexed keywords

3,4 METHYLENEDIOXYMETHAMPHETAMINE;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOENERGY; CELL LINE; CONTROLLED STUDY; DRUG ABUSE; INCUBATION TIME; LIVER; MALE; MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; NONHUMAN; OXIDATIVE PHOSPHORYLATION UNCOUPLING; OXYGEN CONSUMPTION; PRIORITY JOURNAL; RAT; REACTION TIME;

ANIMALS; CELL RESPIRATION; DOSE-RESPONSE RELATIONSHIP, DRUG; ENERGY METABOLISM; MALE; MEMBRANE POTENTIALS; MITOCHONDRIA, LIVER; N-METHYL-3,4-METHYLENEDIOXYAMPHETAMINE; OXYGEN CONSUMPTION; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY;

EID: 3042513385     PISSN: 10696563     EISSN: None     Source Type: Journal    
DOI: 10.1197/j.aem.2004.03.004     Document Type: Article

References (42)

1. Johnston L.D., O'Malley P.M., Bachman J.G. Monitoring the Future - national survey results on drug use, 1975-2002. 2003;National Institute on Drug Abuse, Bethesda, MD. p 520
2. Mallick A., Bodenham A.R. MDMA induced hyperthermia: a survivor with an initial body temperature of 42.9 degrees C. J Emerg Med. 14:1997;336-338
3. Dar K.J., McBrien M.E. MDMA induced hyperthermia: report of a fatality and review of current therapy. Intensive Care Med. 22:1996;995-996
4. Ball J., Garfield T., Morin C., Steele D. Emergency Department Trends from DAWN: Final Estimates 1995-2002. 2003;Substance Abuse and Mental Health Services Administration, Rockville, MD
5. Randall T. Ecstasy-fueled "rave" parties become dances of death for English youths. JAMA. 268:1992;1505-1506
6. McCann U.D., Ricaurte G.A. Lasting neuropsychiatric sequelae of (+/-) methylenedioxymethamphetamine ("ecstasy") in recreational users. J Clin Psychopharmacol. 11:1991;302-305
7. Gowing L.R., Henry-Edwards S.M., Irvine R.J., Ali R.L. The health effects of ecstasy: a literature review. Drug Alcohol Rev. 21:2002;53-63
8. Henry J.A., Jeffreys K.J., Dawling S. Toxicity and deaths from 3, 4-methylenedioxymethamphetamine ("ecstasy"). Lancet. 340:1992;384-387
9. Nimmo S.M., Kennedy B.W., Tullett W.M., Blyth A.S., Dougall J.R. Drug-induced hyperthermia. Anaesthesia. 48:1993;892-895
10. Simpson D.L., Rumack B.H. Methylenedioxyamphetamine. Clinical description of overdose, death, and review of pharmacology. Arch Intern Med. 141:1981;1507-1509
11. Coore J.R. A fatal trip with ecstasy: a case of 3, 4- methylenedioxymethamphetamine/3, 4-methylenedioxyamphetamine toxicity. J R Soc Med. 89:1996;51P-52P
12. Watson J.D., Ferguson C., Hinds C.J., Skinner R., Coakley J.H. Exertional heat stroke induced by amphetamine analogues. Does dantrolene have a place? Anaesthesia. 48:1993;1057-1060
13. Mueller P.D., Korey W.S. Death by "ecstasy": the serotonin syndrome? Ann Emerg Med. 32:1998;377-380
14. Demirkiran M., Jankovic J., Dean J.M. Ecstasy intoxication: an overlap between serotonin syndrome and neuroleptic malignant syndrome. Clin Neuropharmacol. 19:1996;157-164
15. Denborough M.A., Hopkinson K.C. Dantrolene and "ecstasy" [letter] Med J Aust. 166:1997;165-166
16. Mahmud T., Rafi S.S., Scott D.L., Wrigglesworth J.M., Bjarnason I. Nonsteroidal antiinflammatory drugs and uncoupling of mitochondrial oxidative phosphorylation. Arthritis Rheum. 39:1996;1998-2003
17. Dabadie P., Bendriss P., Erny P., Mazat J.P. Uncoupling effects of local anesthetics on rat liver mitochondria. FEBS Lett. 226:1987;77-82
18. Petrescu I., Tarba C. Uncoupling effects of diclofenac and aspirin in the perfused liver and isolated hepatic mitochondria of rat. Biochim Biophys Acta. 1318:1997;385-394
19. Parascandola J. Dinitrophenol and bioenergetics: an historical perspective. Mol Cell Biochem. 5:1974;69-77
20. Nelson B.D., Drake R., McDaniel O. Effects in vitro and in vivo of methylenedioxyphenyl compounds on oxidative phosphorylation in rat liver mitochondria. Biochem Pharmacol. 20:1971;1139-1149
21. Zychlinski L., Montgomery M.R. Chlorphentermine-induced biochemical alterations in mitochondrial membranes. J Pharmacol Exp Ther. 233:1985;39-44
22. Yeh S.Y. Effects of salicylate on 3, 4-methylenedioxymethamphetamine (MDMA)-induced neurotoxicity in rats. Pharmacol Biochem Behav. 58:1997;701-708
23. Tokumitsu Y., Lee S., Ui M. In vitro effects of nonsteroidal anti-inflammatory drugs on oxidative phosphorylation in rat liver mitochondria. Biochem Pharmacol. 26:1977;2101-2106
24. Starkov A.A., Wallace K.B. Structural determinants of fluorochemical-induced mitochondrial dysfunction. Toxicol Sci. 66:2002;244-252
25. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 72:1976;248-254
26. Estabrook R.W. Mitochondrial respiratory control and the polarographic measurement of ADP/O ratios. Methods Enzymol. 10:1967;41-47
27. Isenberg J.S., Klaunig J.E. Role of the mitochondrial membrane permeability transition (MPT) in rotenone-induced apoptosis in liver cells. Toxicol Sci. 53:2000;340-351
28. Skulachev V.P. Uncoupling: new approaches to an old problem of bioenergetics. Biochim Biophys Acta. 1363:1998;100-124
29. Wallace K.B., Starkov A.A. Mitochondrial targets of drug toxicity. Ann Rev Pharmacol Toxicol. 40:2000;353-388
30. Jorens P.G., Schepens P.J. Human pentachlorophenol poisoning. Hum Exp Toxicol. 12:1993;479-495
31. Leftwich R.B., Floro J.F., Neal R.A., Wood A.J. Dinitrophenol poisoning: a diagnosis to consider in undiagnosed fever. South Med J. 75:1982;182-184
32. Boss O., Hagen T., Lowell B.B. Uncoupling proteins 2 and 3: potential regulators of mitochondrial energy metabolism. Diabetes. 49:2000;143-156
33. Sprague J.E., Banks M.L., Cook V.J., Mills E.M. Hypothalamic-pituitary- thyroid axis and sympathetic nervous system involvement in hyperthermia induced by 3, 4-methylenedioxymethamphetamine (Ecstasy). J Pharmacol Exp Ther. 305:2003;159-166
34. Lanni A., Moreno M., Lombardi A., Goglia F. Thyroid hormone and uncoupling proteins. FEBS Lett. 543:2003;5-10
35. Gong D.W., He Y., Karas M., Reirman M. Uncoupling protein-3 is a mediator of thermogenesis regulated by thyroid hormone, beta3-adrenergic agonists, and leptin. J Biol Chem. 272:1997;24129-24132
36. Mills E.M., Banks M.L., Sprague J.E., Finkel T. Pharmacology: uncoupling the agony from ecstasy. Nature. 426:2003;403-404
37. Fleury C., Neverova M., Collins S., et al. Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia. Nat Genet. 15:1997;269-272
38. Larrouy D., Laharrague P., Carrera G., et al. Kupffer cells are a dominant site of uncoupling protein 2 expression in rat liver. Biochem Biophys Res Commun. 235:1997;760-764
39. Teter C.J., Guthrie S.K. A comprehensive review of MDMA and GHB: two common club drugs. Pharmacotherapy. 21:2001;1486-1513
40. Grisham J.W. Cell types in long-term propagable cultures of rat liver. Ann N Y Acad Sci. 349:1980;128-137
41. Brooks G.A., Hittelman K.J., Faulkner J.A., Beyer R.E. Temperature, liver mitochondrial respiratory functions, and oxygen debt. Med Sci Sports. 3:1971;72-74
42. Tobin R.B., Mackerer C.R., Mehlman M.A. pH effects on oxidative phosphorylation of rat liver mitochondria. Am J Physiol. 223:1972;83-88