Effects of clofazimine on potassium uptake by a Trk-deletion mutant of Mycobacterium tuberculosis

Journal of Antimicrobial Chemotherapy

Volumn 57, Issue 1, 2006, Pages 79-84

  Cholo, M C ^a   Boshoff, H I ^b   Steel, H C ^c   Cockeran, R ^c   Matlola, N M ^c,e   Downing, K J ^d,f   Mizrahi, V ^d   Anderson, R ^c  

^a SOUTH AFRICAN MEDICAL RESEARCH COUNCIL   (South Africa)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^c UNIVERSITY OF PRETORIA   (South Africa)

^d UNIVERSITY OF THE WITWATERSRAND   (South Africa)

^e Schering Plough (Pty) Ltd   (South Africa)

^f UNIVERSITY OF CAPE TOWN   (South Africa)

Author keywords

CeoB and ceoC genes; Growth rate; Uptake of rubidium

Indexed keywords

CLOFAZIMINE; PROTEIN CEOB; PROTEIN CEOC; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE A; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL GROWTH; BACTERIAL MEMBRANE; BACTERIUM MUTANT; CONTROLLED STUDY; DRUG EXPOSURE; ENZYME INACTIVATION; GENE DELETION; GROWTH RATE; HOMOLOGOUS RECOMBINATION; KNOCKOUT GENE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; POTASSIUM TRANSPORT; RADIOASSAY; WILD TYPE;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BASE SEQUENCE; CARRIER PROTEINS; CLOFAZIMINE; MOLECULAR SEQUENCE DATA; MUTATION; MYCOBACTERIUM TUBERCULOSIS; PLASMIDS; POTASSIUM; SEQUENCE DELETION;

EID: 30344480800     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dki409     Document Type: Article

References (27)

1. + transport systems in prokaryotes. In: Bakker EP, ed. Alkaline Cation Transport Systems in Prokaryotes. Boca Raton, USA: CRC Press Inc., 1993; 205-25.
2. Epstein W. The roles and regulation of potassium in bacteria. Prog Nucleic Acid Res Mol Biol 2003; 75: 293-320.
3. Cole ST, Brosch R, Parkhill J et al. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature 1998; 393: 537-44.
4. +-binding proteins in mycobacterial INH resistance. Infect Immun 1998; 66: 5099-106.
5. 37Rv KdpD with members of the Lpr family. Mol Microbiol 2003; 46: 1075-89.
6. + concentration. J Bacteriol 2001; 183: 3800-3.
7. 2 activity. J Antimicrob Chemother 1999; 44: 209-16.
8. Matlola NM, Steel HC, Anderson R. Antimycobacterial action of B4128, a novel tetramethylpiperidyl-substituted phenazine. J Antimicrob Chemother 2001; 47: 199-202.
9. Bopape MC, Steel HC, Cockeran R et al. Antimicrobial activity of clofazimine is not dependent on mycobacterial C-type phospholipases. J Antimicrob Chemother 2004; 53: 971-4.
10. Sambrook J, Maniatis T, Fritsch EE. Molecular Cloning: A Laboratory Manual. Cold Spring Harbor, NY, USA: Cold Spring Harbor Laboratory, 1989; 1.21-1.110.
11. 37Rv bacterial artificial chromosome library for genome mapping, sequencing and comparative genomics. Infect Immun 1998; 66: 2221-9.
12. Parish T, Stoker NG. Use of a flexible cassette method to generate a double unmarked Mycobacterium tuberculosis tlyA plcABC mutant by gene replacement. Microbiology 2000; 146: 1969-75.
13. Blondelet-Rouault MH, Weiser J, Lebrihi A et al. Antibiotic resistance gene cassettes derived from omega interposon for use in Escherichia coli and Streptomyces. Gene 1997; 190: 315-7.
14. Hinds J, Mahenthiralinga M, Kempsell KE et al. Enhanced gene replacement in mycobacteria. Microbiology 1999; 145: 519-27.
15. Belisle JT, Sonnenberg MG. Isolation of genomic DNA from mycobacteria. Methods Mol Biol 1998; 101: 31-44.
16. Gordhan BG, Anderson SJ, De Meyer AR et al. Construction by homologous recombination and phenotypic characterization of a DNA polymerase domain polA mutant of Mycobacterium smegmatis. Gene 1996; 178: 125-30.
17. De Bruyn EE, Steel HC, Van Rensburg CE et al. The riminophenazines, clofazimine and B669, inhibit potassium transport in Gram-positive bacteria by a lysophospholipid-dependent mechanism. J Antimicrob Chemother 1996; 38: 349-62.
18. Oliva B, O'Neill AJ, Miller K et al. Anti-staphylococcal activity and mode of action of clofazimine. J Antimicrob Chemother 2004; 53: 435-40.
19. O'Neill AJ, Miller K, Oliva B et al. Comparison of assays for detection of agents causing membrane damage in Staphylococcus aureus. J Antimicrob Chemother 2004; 54: 1127-9.
20. Russell AD. Whither triclosan? J Antimicrob Chemother 2004; 53: 693-5.
21. Zhang YM, Lu YJ, Rock CO. The reductase steps of the type II fatty acid synthase as antimicrobial targets. Lipids 2004; 39: 1055-60.
22. + transport in Escherichia coli K-12. J Biol Chem 1977; 252: 1394-401.
23. Crowle AJ. Intracellular killing of mycobacteria. Res Microbiol 1990; 141: 231-6.
24. Clemens DL, Horwitz MA. Characterization of the Mycobacterium tuberculosis phagosome and evidence that phagosome maturation is inhibited. J Exp Med 1995; 18: 257-70.
25. Clemens DL, Lee B, Horwitz MA. The Mycobacterium tuberculosis phagosome in human macrophages is isolated from the host cell cytoplasm. Infect Immun 2002; 70: 5800-7.
26. + transport ATPase. Curr Top Mem Transp 1985; 23: 153-75.
27. Rengarajan J, Bloom BR, Rubin EJ. Genome-wide requirements for Mycobacterium tuberculosis adaptation and survival in macrophages. Proc Natl Acad Sci USA 2005; 102: 8327-32.