Simultaneous donor marrow cell transplantation with reduced intensity conditioning prevents tracheal allograft obliteration in a bronchiolitis obliterans murine model

Chest

Volumn 128, Issue 6, 2005, Pages 4024-4029

  Nusair, Samir ^a   Or, Reuven ^a   Junadi, Samer ^a   Amir, Gail ^a   Breuer, Raphael ^a  

^a HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

Author keywords

Airway fibroproliferative lesion; Bone marrow transplantation; Cyclophosphamide; Immune tolerance; Lung transplantation; Murine model; Total lymphoid irradiation; Tracheal transplantation

Indexed keywords

CYCLOPHOSPHAMIDE;

ALLOGRAFT; ALLOIMMUNITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW TRANSPLANTATION; BRONCHIOLITIS OBLITERANS; CHIMERA; CONTROLLED STUDY; FEMALE; GRAFT VERSUS HOST REACTION; HISTOPATHOLOGY; IMMUNOCOMPETENT CELL; IMMUNOSUPPRESSIVE TREATMENT; ISOGRAFT; KIDNEY TRANSPLANTATION; LIVER GRAFT; LUNG PARENCHYMA; NONHUMAN; PRIORITY JOURNAL; RESPIRATORY EPITHELIUM; RESPIRATORY TRACT DISEASE; SURVIVAL; TRACHEA OBSTRUCTION;

EID: 30344477698     PISSN: 00123692     EISSN: None     Source Type: Journal    
DOI: 10.1378/chest.128.6.4024     Document Type: Article

References (21)

1. Trulock EP, Edwards LB, Taylor DO, et al. The Registry of the International Society for Heart and Lung Transplantation: Twentieth official adult lung and heart-lung transplant report-2003. J Heart Lung Transplant 2003; 22:625-635
2. Brock MV, Borja MC, Ferber L, et al. Induction therapy in lung transplantation: a prospective, controlled clinical trial comparing OKT3, anti-thymocyte globulin, and daclizumab. J Heart Lung Transplant 2001; 20:1282-1290
3. Date H, Lynch JP, Sundaresan S, et al. The impact of cytolytic therapy on bronchiolitis obliterans syndrome. J Heart Lung Transplant 1998; 17:869-875
4. Valentine VG, Robbins RC, Wehner JH, et al. Total lymphoid irradiation for refractory acute rejection in heart-lung and lung allografts. Chest 1996; 109:1184-1189
5. Starzl TE, Demetris A, Trucco M, et al. Chimerism and donor specific nonreactivity 27 to 29 years after kidney allotransplantation. Transplantation 1993; 55:1272-1277
6. Starzl TE, Demetris AJ, Trucco M, et al. Cell migration and chimerism after whole-organ transplantation: the basis of graft acceptance. Hepatology 1993; 17:1127-1152
7. Ueda M, Hundrieser J, Hisanaga M, et al. Development of microchimerism in pediatric patients after living-related liver transplantation. Clin Transplant 1997; 11:193-200
8. Hisanaga M, Hundrieser J, Boker K. Development, stability, and clinical correlations of allogeneic microchimerism after solid organ transplantation. Transplantation 1996; 61:40-45
9. Prighozina TB, Gurevitch O, Slavin S. Nonmyeloablative conditioning to induce bilateral tolerance after allogeneic bone marrow transplantation in mice. Exp Hematol 1999; 27:1503-1510
10. Pham SM, Mitruka SN, Youm W, et al. Mixed hematopoietic chimerism induces donor-specific tolerance for lung allografts in rodents. Am J Respir Crit Care Med 1999; 159:199-205
11. Gammie JS, Li S, Kawaharada N, et al. Mixed allogeneic chimerism prevents obstructive airway disease in a rat heterotopic tracheal transplant model. J Heart Lung Transplant 1998; 17:801-808
12. Hertz MI, Jessurun J, King MB, et al. Reproduction of the obliterative bronchiolitis lesion after heterotopic transplantation of mouse airways. Am J Pathol 1993; 142:1945-1951
13. Boehler A, Chamberlain D, Kesten S, et al. Lymphocytic airway infiltration as a precursor to fibrous obliteration in a rat model of bronchiolitis obliterans. Transplantation 1997; 64:311-317
14. Slavin S, Strober S, Fuks Z, et al. Induction of specific tissue transplantation tolerance using fractionated total lymphoid irradiation in adult mice: long-term survival of allogeneic bone marrow and skin grafts. J Exp Med 1977; 146:34-38
15. Snedecor GW, Cochran GW. Statistical methods. 6th ed. Ames, IA: Iowa State University Press, 1967; 258-298
16. Rappaport H, Khalil A, Halle-Pannenko O, et al. Histopathologic sequence of events in adult mice undergoing lethal graft-versus-host reaction developed across H-2 and/or non-H-2 histocompatibility barriers. Am J Pathol 1979; 96:121-142
17. Duncan SR, Valentine V, Roglic M, et al. T cell receptor biases and clonal proliferations among lung transplant recipients with obliterative bronchiolitis. J Clin Invest 1996; 97:2642-2650
18. Pham SM, Keenan RJ, Rao AS, et al. Perioperative donor bone marrow infusion augments chimerism in heart and lung transplant recipients. Ann Thorac Surg 1995; 60:1015-1020
19. Pham SM, Rao AS, Zeevi A, et al. Effects of donor bone marrow infusion in clinical lung transplantation. Ann Thorac Surg 2000; 69:345-350
20. Hengst JC, Kempf RA. Immunomodulation by cyclophosphamide. Clin Immunol Allergy 1984; 4:199-216
21. Slavin S, Strober S. Induction of allograft tolerance after total lymphoid irradiation (TLI): development of suppressor cells of the mixed leukocyte reaction (MLR). J Immunol 1979; 123:942-946