Potent gastric acid inhibition in Helicobacter pylori eradication

Drugs

Volumn 65, Issue SUPPL. 1, 2005, Pages 83-96

  Gisbert, Javier P ^a,b  

^a HOSPITAL UNIVERSITARIO DE LA PRINCESA   (Spain)

^b Urb Bonanza   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

AMOXICILLIN; ANTIBIOTIC AGENT; CLARITHROMYCIN; ESOMEPRAZOLE; HISTAMINE H2 RECEPTOR ANTAGONIST; LANSOPRAZOLE; METRONIDAZOLE; OMEPRAZOLE; PANTOPRAZOLE; PROTON PUMP INHIBITOR; RABEPRAZOLE; RANITIDINE; STOMACH SECRETION INHIBITOR;

ANTIBACTERIAL ACTIVITY; CLINICAL TRIAL; COST BENEFIT ANALYSIS; DOSE RESPONSE; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DOSE REDUCTION; DRUG DOSE REGIMEN; DRUG EFFICACY; DRUG MARKETING; DRUG MEGADOSE; DRUG METABOLISM; DRUG POTENCY; ERADICATION THERAPY; ESOPHAGITIS; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HUMAN; INHIBITION KINETICS; META ANALYSIS; MINIMUM INHIBITORY CONCENTRATION; MONOTHERAPY; REVIEW; STOMACH ACID; STOMACH PH; SYSTEMATIC REVIEW;

HELICOBACTER; HELICOBACTER PYLORI;

EID: 30344462994     PISSN: 00126667     EISSN: 00126667     Source Type: Journal    
DOI: 10.2165/00003495-200565001-00012     Document Type: Review

References (147)

1. Sainz R, Borda F, Dominguez E, et al. Helicobacter pylori infection. The Spanish consensus report. The Spanish Consensus Conference Group. Rev Esp Enferm Dig 1999; 91: 777-84
2. Gisbert JP, Calvet X, Gomollon F, et al. Treatment for the eradication of Helicobacter pylori. Recommendations of the Spanish Consensus Conference. Med Clin (Barc) 2000; 114: 185-95
3. Gisbert JP, Pajares JM. Helicobacter pylori therapy: first-line options and rescue regimen. Dig Dis 2001; 19: 134-43
4. Hentschel E, Brandstatter G, Dragosics B, et al. Effect of ranitidine and amoxicillin plus metronidazole on the eradication of Helicobacter pylori and the recurrence of duodenal ulcer [see comments]. N Engl J Med 1993; 328: 308-12
5. Goh KL, Parasakthi N, Chuah SY, et al. Combination amoxycillin and metronidazole with famotidine in the eradication of Helicobacter pylori - a randomized, double-blind comparison of a three times daily and twice daily regimen. Eur J Gastroenterol Hepatol 1997; 9: 1091-5
6. Yousfi MM, El-Zimaity HM, Cole RA, et al. Metronidazole, ranitidine and clarithromycin combination for treatment of Helicobacter pylori infection (modified Bazzoli's triple therapy). Aliment Pharmacol Ther 1996; 10: 119-22
7. Drake IM, Axon TT, Clarke AH. Ranitidine in a twice daily triple-therapy regimen for the eradication of Helicobacter pylori [see comments]. Eur J Gastroenterol Hepatol 1996; 8: 1169-73
8. Breuer T, Kim JG, el-Zimaity HM, et al. Clarithromycin, amoxycillin and H2-receptor antagonist therapy for Helicobacter pylori peptic ulcer disease in Korea [published erratum in Aliment Pharmacol Ther 1999; 13:567]. Aliment Pharmacol Ther 1997; 11: 939-42
9. Gschwantler M, Dragosics B, Wurzer H, et al. Eradication of Helicobacter pylori by a 1-week course of famotidine, amoxicillin and clarithromycin. Eur J Gastroenterol Hepatol 1998; 10: 579-82
10. Hulten K, Jaup B, Stenquist B, et al. Combination treatment with ranitidine is highly efficient against Helicobacter pylori despite negative impact of macrolide resistance. Helicobacter 1997; 2: 188-93
11. Lo WC, Lin HJ, Wang K, et al. Clarithromycin in the combination therapy for the eradication of Helicobacter pylori in peptic ulcer disease. Chung Hua I Hsueh Tsa Chih (Taipei) 1997; 59: 171-6
12. Gotz JM, Veenendaal RA, Veselic M, et al. Triple therapy with ranitidine, clarithromycin, and metronidazole in the treatment of Helicobacter pylori. Scand J Gastroenterol Suppl 1995; 212: 34-7
13. Labenz J. Current role of acid suppressants in Helicobacter pylori eradication therapy. Best Pract Res Clin Gastroenterol 2001; 15: 413-31
14. Savarino V, Sandro Mela G, Zentilin P, et al. Acid inhibition and amoxicillin activity against Helicobacter pylori [Letter; comment]. Am J Gastroenterol 1993; 88: 1975-6
15. Sakaguchi M, Ashida K, Umegaki E, et al. Suppressive action of lansoprazole on gastric acidity and its clinical effect in patients with gastric ulcers: comparison with famotidine. J Clin Gastroenterol 1995; 20: S27-31
16. Holtmann G, Layer P, Goebell H. Are proton pump inhibitors superior to H2 receptor antagonists within the scope of H. pylori eradication therapy? Meta analysis of current parallel group comparisons [see comments] Z Gastroenterol 1996; 34: 267-72
17. Gisbert JP, Khorrami S, Calvet X, et al. Meta-analysis: proton pump inhibitors vs. H2-receptor antagonists - their efficacy with antibiotics in Helicobacter pylori eradication. Aliment Pharmacol Ther 2003; 18: 757-66
18. Adamek RJ, Labenz J. Ranitidine/amoxicillin vs omeprazole/amoxicillin for cure of H. pylori-positive gastric ulcer: role of acid suppression. Gastroenterology 1995; 108: A44
19. Borody TJ, Andrews P, Fracchia G, et al. Omeprazole enhances efficacy of triple therapy in eradicating Helicobacter pylori. Gut 1995; 37: 477-81
20. Cataldo MG, Brancato D, Donatelli M, et al. Treatment of patients with duodenal ulcer positive for Helicobacter pylori infection: ranitidine or omeprazole associated with colloidal bismuth subcitrate plus amoxicillin. Curr Ther Res 1996; 57: 168-74
21. Ell C, Schoerner C, Solbach W, et al. The AMOR study: a randomized, double-blinded trial of omeprazole versus ranitidine together with amoxycillin and metronidazole for eradication of Helicobacter pylori. Eur J Gastroenterol Hepatol 2001; 13: 685-91
22. Grigoriev PY, Zoseeva OV, Jakovenko AV, et al. Zantac (ranitidine) - antimicrobial therapy vs omeprazole - antimicrobial therapy for Helicobacter pylori (HP) associated peptic ulcer (PU). Am J Gastroenterol 1994; 89: 1392
23. Gschwantler M, Dragosics B, Schutze K, et al. Famotidine versus omeprazole in combination with clarithromycin and metronidazole for eradication of Helicobacter pylori - a randomized, controlled trial. Aliment Pharmacol Ther 1999; 13: 1063-9
24. Hsu CC, Chen JJ, Hu TH, et al. Famotidine versus omeprazole, in combination with amoxycillin and tinidazole, for eradication of Helicobacter pylori infection. Eur J Gastroenterol Hepatol 2001; 13: 921-6
25. Lamouliatte H. Controlled study of omeprazole-amoxicillin-tinidazole vs. ranitidine-amoxicillin-tinidazole in Helicobacter pylori associated duodenal ulcers (DU), final and long-term results. Ital J Gastroenterol 1991; 23 Suppl 2: 9
26. Lazzaroni M, Bargiggia S, Porro GB. Triple therapy with ranitidine or lansoprazole in the treatment of Helicobacter pylori-associated duodenal ulcer. Am J Gastroenterol 1997; 92: 649-52
27. Mosca S, Rocco VP, De Caprio M, et al. Comparison of two double therapies (nizatidine plus amoxicilline v/s omeprazole plus amoxicilline) in patients with Helicobacter pylori positive duodenal ulcer. Gut 1995; 37 Suppl 2: A226
28. Murakami K, Sato R, Kubota T, et al. Effects of new triple therapy regimens of inhibition of gastric acid secretion and eradication of Helicobacter pylori in a randomized trial. Gastroenterology 1999; 116: A260
29. Oderda G, Caristo P, Kuvidi M, et al. Evaluation of different treatment schedules in childhood Helicobacter pylori gastritis: a 10 year experience. Gut 1999; 45 Suppl 3: A94
30. Popovic N, Bulajic M, Glisic M, et al. Comparison of two triple therapies (ranitidine plus amoxicilline plus tinidazole v/s omeprazole plus amoxicilline plus tinidazol) in patients with Helicobacter pylori positive duodenal ulcer. Gut 1997; 41 Suppl 1: A102
31. Ruszniewski P, Lamouliatte H, Flejou JF, et al. Evaluation of short-term ranitidine vs omeprazole triple therapy regimens for eradication of Helicobacter pylori (Hp) in duodenal ulcer (DU) patients (pts). Gut 1997; 41 Suppl 1: A94
32. Sacca N, De Medici A, Rodino S, et al. Duodenal ulcer Helicobacter pylori (HP) positive: therapy with ranitidine (R) + clarithromicine (C) + metronidazole (M) versus omeprazole (O) + clarithromicine + metronidazole. Gut 1996; 39 Suppl 2: A34
33. Savarino V, Zentilin P, Bisso G, et al. Head-to-head comparison of 1-week triple regimens combining ranitidine or omeprazole with two antibiotics to eradicate Helicobacter pylori. Aliment Pharmacol Ther 1999; 13: 643-9
34. Shcherbakov PL, Filin VA, Volkov IA, et al. A randomized comparison of triple therapy Helicobacter pylori eradication regimens in children with peptic ulcers. J Int Med Res 2001; 29: 147-53
35. Spadaccini A, De Fanis C, Sciampa G, et al. Omeprazole versus ranitidine: short-term triple-therapy in patients with Helicobacter pylori-positive duodenal ulcers. Aliment Pharmacol Ther 1996; 10: 829-31
36. Tham TC, Collins JS, Molloy C, et al. Randomised controlled trial of ranitidine versus omeprazole in combination with antibiotics for eradication of Helicobacter pylori. Ulster Med J 1996; 65: 131-6
37. Treiber G, Ammon S, Klotz U. Age-dependent eradication of Helicobacter pylori with dual therapy. Aliment Pharmacol Ther 1997; 11: 711-8
38. Peterson WL. The role of antisecretory drugs in the treatment of Helicobacter pylori infection. Aliment Pharmacol Ther 1997; 11 Suppl 1: 21-5
39. Klotz U. Pharmacokinetic considerations in the eradication of Helicobacter pylori. Clin Pharmacokinet 2000; 38: 243-70
40. van Zanten SJ, Goldie J, Hollingsworth J, et al. Secretion of intravenously administered antibiotics in gastric juice: implications for management of Helicobacter pylori. J Clin Pathol 1992; 45: 225-7
41. Meyer-Rosberg K, Scott DR, Rex D, et al. The effect of environmental pH on the proton motive force of Helicobacter pylori. Gastroenterology 1996; 111: 886-900
42. Alarcon T, Domingo D, Sanchez I, et al. In vitro activity of omeprazole in combination with several antimicrobial agents against clinical isolates of Helicobacter pylori. Eur J Clin Microbiol Infect Dis 1996; 15: 937-40
43. Cederbrant G, Kahlmeter G, Schalen C, et al. Additive effect of clarithromycin combined with 14-hydroxy clarithromycin, erythromycin, amoxycillin, metronidazole or omeprazole against Helicobacter pylori. J Antimicrob Chemother 1994; 34: 1025-9
44. Grayson ML, Eliopoulos GM, Ferraro MJ, et al. Effect of varying pH on the susceptibility of Campylobacter pylori to antimicrobial agents. Eur J Clin Microbiol Infect Dis 1989; 8: 888-9
45. Goddard AF, Jessa MJ, Barrett DA, et al. Effect of omeprazole on the distribution of metronidazole, amoxicillin, and clarithromycin in human gastric juice [see comments]. Gastroenterology 1996; 111: 358-67
46. Labenz J, Beker JA, Dekker CP, et al. Doubling the omeprazole dose (40 mg b.d. vs. 20 mg b.d.) in dual therapy with amoxycillin increases the cure rate of Helicobacter pylori infection in duodenal ulcer patients. Aliment Pharmacol Ther 1997; 11: 515-22
47. Miehlke S, Mannes GA, Lehn N, et al. An increasing dose of omeprazole combined with amoxycillin cures Helicobacter pylori infection more effectively. Aliment Pharmacol Ther 1997; 11: 323-9
48. Pommerien W, Schultze V, Braden B, et al. Dose-response of omeprazole combined with amoxycillin on duodenal ulcer healing and eradication of Helicobacter pylori. Aliment Pharmacol Ther 1996; 10: 303-8
49. Bayerdorffer E, Miehlke S, Mannes GA, et al. Double-blind trial of omeprazole and amoxicillin to cure Helicobacter pylori infection in patients with duodenal ulcers. Gastroenterology 1995; 108: 1412-7
50. Labenz J, Stolte M, Blum AL, et al. Intragastric acidity as a predictor of the success of Helicobacter pylori eradication: a study in peptic ulcer patients with omeprazole and amoxicillin. Gut 1995; 37: 39-43
51. Sjostedt S, Sagar M, Lindberg G, et al. Prolonged and profound acid inhibition is crucial in Helicobacter pylori treatment with a proton pump inhibitor combined with amoxicillin [see comments]. Scand J Gastroenterol 1998; 33: 39-43
52. Kleveland PM, Waldum HL, Brenna E, et al. Relationship between the efficacy of amoxicillin and intragastric pH for the treatment of Helicobacter pylori infection. Helicobacter 1997; 2: 144-8
53. van der Hulst RW, Weel JF, Verheul SB, et al. Treatment of Helicobacter pylori infection with low or high dose omeprazole combined with amoxycillin and the effect of early retreatment. Aliment Pharmacol Ther 1996; 10: 165-71
54. Malaty H, el-Zimaity HM, Genta RM, et al. High-dose proton pump inhibitor plus amoxycillin for the treatment or retreatment of Helicobacter pylori infection. Aliment Pharmacol Ther 1996; 10: 1001-4
55. Erah PO, Goddard AF, Barrett DA, et al. The stability of amoxycillin, clarithromycin and metronidazole in gastric juice: relevance to the treatment of Helicobacter pylori infection. J Antimicrob Chemother 1997; 39: 5-12
56. Huang J, Hunt RH. The importance of clarithromycin dose in the management of Helicobacter pylori infection: a meta-analysis of triple therapies with a proton pump inhibitor, clarithromycin and amoxycillin or metronidazole [see comments]. Aliment Pharmacol Ther 1999; 13: 719-29
57. Vallve M, Vergara M, Gisbert JP, et al. Single vs. double dose of a proton pump inhibitor in triple therapy for Helicobacter pylori eradication: a meta-analysis. Aliment Pharmacol Ther 2002; 16: 1149-56
58. Bardhan KD, Dillon J, Axon AT, et al. Triple therapy for Helicobacter pylori eradication: a comparison of pantoprazole once versus twice daily. Aliment Pharmacol Ther 2000; 14: 59-67
59. Chiba N, Marshall CP. Omeprazole once or twice daily with clarithromycin and metronidazole for Helicobacter pylori. Can J Gastroenterol 2000; 14: 27-31
60. Megraud F, Boyanova L, Lamouliatte H. Activity of lansoprazole against Helicobacter pylori [Letter]. Lancet 1991; 337: 1486
61. Alarcon T, Domingo D, Sanchez I, et al. In vitro activity of ebrotidine, ranitidine, omeprazole, lansoprazole, and bismuth citrate against clinical isolates of Helicobacter pylori. Eur J Clin Microbiol Infect Dis 1998; 17: 275-7
62. Stedman CA, Barclay ML. Review article: comparison of the pharmacokinetics, acid suppression and efficacy of proton pump inhibitors. Aliment Pharmacol Ther 2000; 14: 963-78
63. Powell KU, Bell GD, Bowden AF, et al. Helicobacter pylori eradication therapy: a comparison between either omeprazole or ranitidine in combination with amoxycillin plus metronidazole. Br J Clin Res 1995; 6: 163-9
64. Rollan A, Giancaspero R, Acevedo C, et al. Treatment of Helicobacter pylori infection in patients with duodenal ulcer: a cost-benefit study. Rev Med Chil 2000; 128: 367-77
65. Gisbert JP. Lansoprazole: a review of its role in Helicobacter pylori eradication therapy. Rev Esp Enferm Dig 1999; 91: 133-43
66. Huber R, Kohl B, Sachs G, et al. Review article: the continuing development of proton pump inhibitors with particular reference to pantoprazole. Aliment Pharmacol Ther 1995; 9: 363-78
67. Fitton A, Wiseman L, Pantoprazole. A review of its pharmacological properties and therapeutic use in acid-related disorders. Drugs 1996; 51: 460-82
68. Parsons ME. Pantoprazole, a new proton-pump inhibitor, has a precise and predictable profile of activity. Eur J Gastroenterol Hepatol 1996; 8 Suppl 1: S15-20
69. Gisbert JP, Boixeda D, Martin de Argila C, et al. Role of pantoprazole in the eradicating treatment of Helicobacter pylori. Rev Clin Esp 1998; 198: 678-83
70. Thomson AB. Are the orally administered proton pump inhibitors equivalent? a comparison of lansoprazole, omeprazole, pantoprazole, and rabeprazole Curr Gastroenterol Rep 2000; 2: 482-93
71. Horn J. The proton-pump inhibitors: similarities and differences. Clin Ther 2000; 22: 266-80; discussion 265
72. Jungnickel PW. Pantoprazole: a new proton pump inhibitor. Clin Ther 2000; 22: 1268-93
73. Poole P. Pantoprazole. Am J Health Syst Pharm 2001; 58: 999-1008
74. Suerbaum S, Leying H, Klemm K, et al. Antibacterial activity of pantoprazole and omeprazole against Helicobacter pylori [Letter]. Eur J Clin Microbiol Infect Dis 1991; 10: 92-3
75. Nakao M, Malfertheiner P. Growth inhibitory and bactericidal activities of lansoprazole compared with those of omeprazole and pantoprazole against Helicobacter pylori. Helicobacter 1998; 3: 21-7
76. Dattilo M, Figura N. Helicobacter pylori infection, chronic gastritis, and proton pump inhibitors. J Clin Gastroenterol 1998; 27 Suppl 1: S163-9
77. Hartmann M, Theiss U, Huber R, et al. Twenty-four-hour intragastric pH profiles and pharmacokinetics following single and repeated oral administration of the proton pump inhibitor pantoprazole in comparison to omeprazole. Aliment Pharmacol Ther 1996; 10: 359-66
78. Gisbert JP, Khorrami S, Calvet X, et al. Pantoprazole based therapies in Helicobacter pylori eradication: systematic review and meta-analysis. Eur J Gastroenterol Hepatol 2004; 16: 89-99
79. Unge P. What other regimens are under investigation to treat Helicobacter pylori infection? Gastroenterology 1997; 113: S131-48
80. Pipkin GA, Williamson R, Wood JR. Review article: one-week clarithromycin triple therapy regimens for eradication of Helicobacter pylori. Aliment Pharmacol Ther 1998; 12: 823-37
81. Laheij RJ, Rossum LG, Jansen JB, et al. Evaluation of treatment regimens to cure Helicobacter pylori infection - a meta-analysis. Aliment Pharmacol Ther 1999; 13: 857-64
82. Gisbert JP, Carpio D, Marcos S, et al. One-week therapy with pantoprazole versus ranitidine bismuth citrate plus two antibiotics for Helicobacter pylori eradication. Eur J Gastroenterol Hepatol 2000; 12: 489-95
83. Svoboda P, Kantorova I, Ochmann J, et al. Pantoprazole-based dual and triple therapy for the eradication of Helicobacter pylori infection: a randomized controlled trial. Hepatogastroenterology 1997; 44: 886-90
84. Adamek RJ, Bethke TD. Cure of Helicobacter pylori infection and healing of duodenal ulcer: comparison of pantoprazole-based one-week modified triple therapy versus two-week dual therapy. The International Pantoprazole HP Study Group. Am J Gastroenterol 1998; 93: 1919-24
85. Adamek RJ, Suerbaum S, Pfaffenbach B, et al. Primary and acquired Helicobacter pylori resistance to clarithromycin, metronidazole, and amoxicillin - influence on treatment outcome. Am J Gastroenterol 1998; 93: 386-9
86. Dehesa M, Larisch J, Di Silvio M, et al. Comparison of three seven days pantoprazole (panto) based Helicobacter pylori (Hp) eradication schemes in a Mexican population with highly metronidazole (met) resistant Hp strains [Abstract]. Gastroenterology 1998; 114: A288
87. Lamouliatte H, Samoyeau R, De Mascarel A, et al. Double vs. single dose of pantoprazole in combination with clarithromycin and amoxycillin for 7 days, in eradication of Helicobacter pylori in patients with non-ulcer dyspepsia. Aliment Pharmacol Ther 1999; 13: 1523-30
88. Adamek RJ, Szymanski C, Pfaffenbach B. Pantoprazole versus omeprazole in one-week low-dose triple therapy for cure of H. pylori infection. Am J Gastroenterol 1997; 92: 1949-50
89. Cammarota G, Papa A, Cianci R, et al. Three-day antibiotic therapy with azithromycin and tinidazole plus lansoprazole or pantoprazole to cure Helicobacter pylori infection: a pilot study. Eur J Gastroenterol Hepatol 1999; 11: 247-50
90. Catalano F, Branciforte G, Catanzaro R, et al. Comparative treatment of Helicobacter pylori-positive duodenal ulcer using pantoprazole at low and high doses versus omeprazole in triple therapy. Helicobacter 1999; 4: 178-84
91. Catalano F, Catanzaro R, Branciforte G, et al. Five-day triple therapy in Helicobacter pylori-positive duodenal ulcer: an eighteen-month follow-up. J Clin Gastroenterol 2000; 31: 130-6
92. Dominguez-Martin A, Dominguez-Muñoz A, Muñoz S, et al. Efficacy of six days triple therapy with pantoprazole plus clarithromycin and amoxycillin versus omeprazole plus clarithromycin and amoxycillin for H. pylori eradication [Abstract]. Gastroenterology 1998; 114: A107
93. Rinaldi V, Zullo A, De Francesco V, et al. Helicobacter pylori eradication with proton pump inhibitor-based triple therapies and re-treatment with ranitidine bismuth citrate-based triple therapy. Aliment Pharmacol Ther 1999; 13: 163-8
94. Salces I, Soto S, Diaz-Tasende J, et al. Estudio comparativo de 3 pautas de erradicación de H. pylori [Abstract]. Rev Esp Enferm Dig 2001; 93 Suppl I: 156
95. Prakash A, Faulds D. Rabeprazole. Drugs 1998; 55: 261-7
96. Langtry HD, Markham A. Rabeprazole: a review of its use in acid-related gastrointestinal disorders. Drugs 1999; 58: 725-42
97. Williams MP, Pounder RE. Review article: the pharmacology of rabeprazole. Aliment Pharmacol Ther 1999; 13 Suppl 3: 3-10
98. Carswell CI, Goa KL. Rabeprazole: an update of its use in acid-related disorders. Drugs 2001; 61: 2327-56
99. Williams MP, Sercombe J, Hamilton MI, et al. A placebo-controlled trial to assess the effects of 8 days of dosing with rabeprazole versus omeprazole on 24-h intragastric acidity and plasma gastrin concentrations in young healthy male subjects. Aliment Pharmacol Ther 1998; 12: 1079-89
100. Ohning GV, Barbuti RC, Kovacs TO, et al. Rabeprazole produces rapid, potent, and long-acting inhibition of gastric acid secretion in subjects with Helicobacter pylori infection. Aliment Pharmacol Ther 2000; 14: 701-8
101. Hirai M, Azuma T, Ito S, et al. A proton pump inhibitor, E3810, has antibacterial activity through binding to Helicobacter pylori. J Gastroenterol 1995; 30: 461-4
102. Kawakami Y, Akahane T, Yamaguchi M, et al. In vitro activities of rabeprazole, a novel proton pump inhibitor, and its thioether derivative alone and in combination with other antimicrobials against recent clinical isolates of Helicobacter pylori. Antimicrob Agents Chemother 2000; 44: 458-61
103. Fujioka T, Kawasaki H, Su WW, et al. In vitro antimicrobial activity against H. pylori and clinical efficacy of various drugs. Nippon Rinsho 1993; 51: 3255-60
104. Fujiyama K, Fujioka T, Kodama R, et al. Effect of E3810, a novel proton pump inhibitor, against Helicobacter pylori [Abstract]. Am J Gastroenterol 1994; 89: 1371
105. Tsutsui N, Taneike I, Ohara T, et al. A novel action of the proton pump inhibitor rabeprazole and its thioether derivative against the motility of Helicobacter pylori. Antimicrob Agents Chemother 2000; 44: 3069-73
106. Ohara T, Goshi S, Taneike I, et al. Inhibitory action of a novel proton pump inhibitor, rabeprazole, and its thioether derivative against the growth and motility of clarithromycin-resistant Helicobacter pylori. Helicobacter 2001; 6: 125-9
107. Lopez-Brea M, Domingo D, Martinez M, et al. In vitro activity of rabeprazole compared with omeprazole in Helicobacter pylori clinical isolates [Abstract]. Gut 2001; 49 Suppl II: A7
108. Bosques-Padilla FJ, Tijerina-Menchaca R, Maldonado-Garza HJ, et al. Bacteriostatic and bactericidal activity of rabeprazole in Helicobacter pylori clinical isolates [Abstract]. Gut 2002; 51 Suppl II: A100
109. Tsuchiya M, Imamura L, Park JB, et al. Helicobacter pylori urease inhibition by rabeprazole, a proton pump inhibitor. Biol Pharm Bull 1995; 18: 1053-6
110. Park JB, Imamura L, Kobashi K. Kinetic studies of Helicobacter pylori urease inhibition by a novel proton pump inhibitor, rabeprazole. Biol Pharm Bull 1996; 19: 182-7
111. Cloud ML, Enas N, Humphries TJ, et al. Rabeprazole in treatment of acid peptic diseases: results of three placebo-controlled dose-response clinical trials in duodenal ulcer, gastric ulcer, and gastroesophageal reflux disease (GERD). The Rabeprazole Study Group. Dig Dis Sci 1998; 43: 993-1000
112. Gisbert JP, Khorrami S, Calvet X, et al. Systematic review: rabeprazole-based therapies in Helicobacter pylori eradication. Aliment Pharmacol Ther 2003; 17: 751-64
113. Dojo M, Azuma T, Saito T, et al. Effects of CYP2C19 gene polymorphism on cure rates for Helicobacter pylori infection by triple therapy with proton pump inhibitor (omeprazole or rabeprazole), amoxycillin and clarithromycin in Japan. Dig Liver Dis 2001; 33: 671-5
114. Inaba T, Mizuno M, Kawai K, et al. Randomized open trial for comparison of proton pump inhibitors in triple therapy for Helicobacter pylori infection in relation to CYP2C19 genotype. J Gastroenterol Hepatol 2002; 17: 748-53
115. Kawabata H, Khayakumo T, Nakajima M, et al. Effects of different PPIs, genetic difference in CYP2C19 status and antibiotic susceptibility patterns on the cure rate of H. pylori infection by one-week triple therapy: results of a randomized trial in Japan [Abstract]. Gastroenterology 2001; 120 Suppl 1: 2964
116. Kuwayama H, Takahashi M, Takada H, et al. Comparison of standard dose rabeprazole and double dose omeprazole in PPI-based triple therapy for Helicobacter pylori infection - a randomized clinical trial [Abstract]. Gastroenterology 2001; 120 Suppl 1: 2970
117. Miki I, Aoyama N, Sakai T, et al. The key to successful eradication of H. pylori, using lansoprazole or rabeprazole based triple therapy, is clarithromycin resistance, not CYP2C19 polymorphism [Abstract]. Gastroenterology 2001; 120 Suppl 1: 2984
118. Miwa H, Ohkura R, Murai T, et al. Impact of rabeprazole, a new proton pump inhibitor, in triple therapy for Helicobacter pylori infection - comparison with omeprazole and lansoprazole. Aliment Pharmacol Ther 1999; 13: 741-6
119. Miwa H, Yamada T, Sato K, et al. Efficacy of reduced dosage of rabeprazole in PPI/AC therapy for Helicobacter pylori infection: comparison of 20 and 40 mg rabeprazole with 60 mg lansoprazole. Dig Dis Sci 2000; 45: 77-82
120. Miyoshi M, Mizuno M, Ishiki K, et al. A randomized open trial for comparison of proton pump inhibitors, omeprazole versus rabeprazole, in dual therapy for Helicobacter pylori infection in relation to CYP2C19 genetic polymorphism. J Gastroenterol Hepatol 2001; 16: 723-8
121. Murakami K, Fujioka T, Okimoto T, et al. Drug combinations with amoxycillin reduce selection of clarithromycin resistance during Helicobacter pylori eradication therapy. Int J Antimicrob Agents 2002; 19: 67-70
122. Vakil N, Schwartz H.J., Lanza FL, et al. A prospective, controlled, randomized trial of 3-, 7-, and 10-day rabeprazole-based triple therapy for H. pylori eradication in the USA [Abstract]. Gastroenterology 2002; 122: 551
123. Wong BC, Wong WM, Yee YK, et al. Rabeprazole-based 3-day and 7-day triple therapy vs. omeprazole-based 7-day triple therapy for the treatment of Helicobacter pylori infection. Aliment Pharmacol Ther 2001; 15: 1959-65
124. Furuta T, Ohashi K, Kamata T, et al. Effect of genetic differences in omeprazole metabolism on cure rates for Helicobacter pylori infection and peptic ulcer. Ann Intern Med 1998; 129: 1027-30
125. Furuta T, Shirai N, Takashima M, et al. Effects of genotypic differences in CYP2C19 status on cure rates for Helicobacter pylori infection by dual therapy with rabeprazole plus amoxicillin. Pharmacogenetics 2001; 11: 341-8
126. Yasuda S, Horai Y, Tomono Y, et al. Comparison of the kinetic disposition and metabolism of E3810, a new proton pump inhibitor, and omeprazole in relation to S-mephenytoin 4′-hydroxylation status. Clin Pharmacol Ther 1995; 58: 143-54
127. VandenBranden M, Ring BJ, Binkley SN, et al. Interaction of human liver cytochromes P450 in vitro with LY307640, a gastric proton pump inhibitor. Pharmacogenetics 1996; 6: 81-91
128. Ishizaki T, Horai Y. Review article: cytochrome P450 and the metabolism of proton pump inhibitors - emphasis on rabeprazole. Aliment Pharmacol Ther 1999; 13 Suppl 3: 27-36
129. Uchihara M, Izumi N, Noguchi O, et al. Cytochrome P450 2C19 (CYP2C19) genotype status is not associated with cure rates of dual therapy with rabeprazole and amoxicillin for Helicobacter pylori [Abstract]. Gastroenterology 2001; 120 Suppl 1: 2985
130. Kawamura N, Sugiyama T, Saito M, et al. Eradication efficacy of rabeprazole, a new proton pump inhibitor, in triple therapy for Helicobacter pylori does not depend on P450 genotype of the patients [Abstract]. Gut 2000; 47 Suppl I: A105
131. Hokari K, Sugiyama T, Kato M, et al. Efficacy of triple therapy with rabeprazole for Helicobacter pylori infection and CYP2C19 genetic polymorphism. Aliment Pharmacol Ther 2001; 15: 1479-84
132. Kawai T, Ogua K, Kudou T, et al. Comparison of dual therapy of rabeprazole plus amoxicillin and triple therapy for cure of Helicobacter pylori infection [Abstract]. Gastroenterology 2001; 120 Suppl 1: 2971
133. Spencer CM, Faulds D. Esomeprazole. Drugs 2000; 60: 321-9; discussion 330-1
134. Scott LJ, Dunn CJ, Mallarkey G, et al. Esomeprazole: a review of its use in the management of acid-related disorders. Drugs 2002; 62: 1503-38
135. Johnson TJ, Hedge DD. Esomeprazole: a clinical review. Am J Health Syst Pharm 2002; 59: 1333-9
136. Johnson DA. Review of esomeprazole in the treatment of acid disorders. Expert Opin Pharmacother 2003; 4: 253-64
137. Kale-Pradhan PB, Landry HK, Sypula WT. Esomeprazole for acid peptic disorders. Ann Pharmacother 2002; 36: 655-63
138. Miner PB Jr, Katz PO, Chen Y, et al. Esomeprazole 40 mg provides more effective intragastric acid suppression at steady state than standard doses of other proton pump inhibitors. Gastroenterology 2003; 124 Suppl 1: 232A
139. Gatta L, Perna F, Figura N, et al. Antimicrobial activity of esomeprazole versus omeprazole against Helicobacter pylori. J Antimicrob Chemother 2003; 51: 439-42
140. Gisbert JP, Pajares JM. Esomeprazole-based therapy in Helicobacter pylori eradication: a meta-analysis. Dig Liver Dis 2004; 36: 253-9
141. Laine L, Fennerty MB, Osato M, et al. Esomeprazole-based Helicobacter pylori eradication therapy and the effect of antibiotic resistance: results of three US multicenter, double-blind trials. Am J Gastroenterol 2000; 95: 3393-8
142. Tulassay Z, Kryszewski A, Dite P, et al. One week of treatment with esomeprazole-based triple therapy eradicates Helicobacter pylori and heals patients with duodenal ulcer disease. Eur J Gastroenterol Hepatol 2001; 13: 1457-65
143. Vasil'ev Iu V, Kas'ianenko VI. Efficacy of the one week treatment with esomeprazole (nexium), clarythromycin, and amoxycillin of duodenal ulcer associated with Helicobacter pylori. Eksp Klin Gastroenterol 2002; 102: 47-51
144. Veldhuyzen Van Zanten S, Lauritsen K, Delchier JC, et al. One-week triple therapy with esomeprazole provides effective eradication of Helicobacter pylori in duodenal ulcer disease. Aliment Pharmacol Ther 2000; 14: 1605-11
145. Veldhuyzen Van Zanten S, Machado S, Lee J. One-week triple therapy with esomeprazole, clarithromycin and metronidazole provides effective eradication of Helicobacter pylori infection. Aliment Pharmacol Ther 2003; 17: 1381-7
146. Laine L. Review article: esomeprazole in the treatment of Helicobacter pylori. Aliment Pharmacol Ther 2002; 16 Suppl 4: 115-8
147. Miehlke S, Ebert S, Kirsch C, et al. One-week triple therapy with esomeprazole, clarithromycin and metronidazole is highly effective in eradicating Helicobater pylori in the absence of antimicrobial resistance - a prospective randomized multicenter trial. Gastroenterology 2003; 124 Suppl 1: M1493