Internal exposure, health effects, and cancer risk of humans exposed to chloronitrobenzene

Environmental Science and Technology

Volumn 40, Issue 1, 2006, Pages 387-394

  Jones, Christopher R ^a,b,c   Liu, Yu Ying ^d   Sepai, Ovnair ^c,e   Yan, Huifang ^d   Sabbioni, Gabriele ^a,b  

^a Institute of Environmental and Occupational Toxicology   (Switzerland)

^b UNIVERSITY OF MUNICH   (Germany)

^c NEWCASTLE UNIVERSITY   (United Kingdom)

^d CHINESE CENTER FOR DISEASE CONTROL AND PREVENTION   (China)

^e PUBLIC HEALTH ENGLAND   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BENZENE; BLOOD; CARCINOGENS; HEALTH RISKS; HYDROLYSIS; PESTICIDES;

CANCER RISK; CHLORONITROBENZENE (CNB); HEALTH EFFECT; RUBBER CHEMICALS;

TUMORS;

1 CHLORO 4 NITROBENZENE; 2 CHLORONITROBENZENE; AROMATIC AMINE; CARCINOGEN; HEMOGLOBIN; NITROBENZENE DERIVATIVE; SULFINAMIDE; UNCLASSIFIED DRUG;

CARCINOGEN; HEALTH IMPACT; HEALTH RISK; OCCUPATIONAL EXPOSURE; POLLUTION EXPOSURE;

ADULT; AIR MONITORING; ARTICLE; BIOLOGICAL MONITORING; BLOOD ANALYSIS; CANCER RISK; CARDIOVASCULAR DISEASE; CHINESE; CLINICAL ARTICLE; DIZZINESS; DYSPNEA; EYE IRRITATION; FATIGUE; FEMALE; GAS CHROMATOGRAPHY; GENOTOXICITY; HEADACHE; HEPATOMEGALY; HUMAN; HYDROLYSIS; INSOMNIA; LONG TERM EXPOSURE; MALE; MASS SPECTROMETRY; OCCUPATIONAL EXPOSURE; QUANTITATIVE ANALYSIS; QUESTIONNAIRE; SKIN IRRITATION; SPLENOMEGALY; URINALYSIS;

AMIDES; AMINES; BIOLOGICAL MARKERS; CHEMICAL INDUSTRY; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HEMOGLOBINS; HUMANS; NEOPLASMS; NITROBENZENES; OCCUPATIONAL EXPOSURE; RISK ASSESSMENT; SULFINIC ACIDS;

EID: 30344458762     PISSN: 0013936X     EISSN: None     Source Type: Journal    
DOI: 10.1021/es050693p     Document Type: Article

References (40)

1. National Toxicology Program (NTP). 2-Chloronitrobenzene, 3-chloronitrobenzene and 4-chloronitrobenzene; Technical Report; Research Triangle Park, NC, 1993; pp 1-100.
2. Gdch-Advisory Committee on Existing Chemicals of Environmental Relevance. o-Chloronitrobenzene; BUA Report No. 2; Verlag Chemie: Weinheim, Germany, 1992.
3. Gdch-Advisory Committee on Existing Chemicals of Environmental Relevance. m-Chloronitrobenzene, p-Chloronitrobenzene; BUA Report No. 11; Verlag Chemie: Weinheim; Germany, 1992.
4. NIOSH/OSHA. Occupational health guideline for p-chloronitrobenzene; Washington, DC, 1978.
5. Feltes, J.; Levsen, K.; Volmer, D.; Spiekermann, M. Gas Chromatographic and mass spectrometric determination of nitroaromatics in water. J. Chromatogr. 1990, 518, 21-40.
6. Yurawecz, M. P.; Puma, B. J. Identification of chlorinated nitrobenzene residues in the Mississippi River fish. J.-Assoc. Off. Anal. Chem. 1983, 66, 1345-1352.
7. U.S. Environmental Protection Agency. Provisional Peer Reviewed Toxicity Values PPRTV Derivation Support Document for p-Chloronitrobenzene (4-Chloronitrobenzene); SRC TR-02-037/09-05-2002; Office of Superfund Remediation and Technology Innovation: Washington, DC, 2002.
8. United Nations Environment Programme (Processed by UNEP Chemicals). OECD Screening Information DataSet, High Production Volume Chemicals: 1-Chloro-2-nitrobenzene; UNEP Publications: Nairobi, Kenya, 2003; pp 1-106.
9. U.S. Environmental Protection Agency. Provisional Peer Reviewed Toxicity Values Derivation Support Document for o-Chloronitrobenzene (2- Chloronitrobenzene); SRC TR-02-036/ 09-10-2002; Office of Superfund Remediation and Technology Innovation: Washington, DC, 2002.
10. IARC (International Agency for Research on Cancer). 2-Chloronitrobenzene, 3-chloronitrobenzene, and 4-chloronitrobenzene. Printing Processes and Printing Inks, Carbon Black and Some Nitro Compounds; IARC Monographs on the Evaluation of Carcinogenic Risks to Humans; Lyon, France. 1996; Vol. 65, pp 263-296.
11. Mortelmans, K.; Zeiger, E. The Ames Salmonella/microsome mutagenicity assay. Mutat. Res. 2000, 455, 29-60.
12. Yoshida, T. Pharmacokinetic study of p-chloronitrobenzene in rat. Drug Metab. Dispos. 1994, 22, 275-280.
13. Yoshida, T.; Tabuchi, T.; Andoh, K. Pharmacokinetic study of p-chloronitrobenzene in humans suffering from acute poisoning. Drug Metab. Dispos. 1993, 21, 1142-1146.
14. Rickert, D. E.; Held, S. D. Metabolism of chloronitrobenzenes by isolated rat hepatocytes. Drug Metab. Dispos. 1990, 18, 5-9.
15. Delclos, K. B.; Kadlubar, F. F. Carcinogenic aromatic amines and amides. In Comprehensive Toxicology. Volume 12, Chemical carcinogens andanticarcinogens; Bowden, G. T., Fischer, S. M., Eds.; Elsevier Science: New York, 1997; pp 141-170.
16. Beland, F. A.; Kadlubar, F. F. Metabolic activation and DNA adducts of aromatic amines and nitroaromatic hydrocarbons. In Chemical Carcinogenesis and Mutagenesis I; Cooper, C. S., Ed.; Springer: Berlin, 1990; Vol. 1, pp 267-325.
17. Sabbioni, G.; Jones, C. R. Biomonitoring of arylamines and nitroarenes. Biomarkers 2002, 7, 347-421.
18. Skipper, P. I.; Tannenbaum, S. R. Molecular dosimetry of aromatic amines in human populations. Environ. Health Perspect. 1994, 102 (Suppl. 6), 17-21.
19. Ringe, D.; Turesky, R. J.; Skipper, P. L.; Tannenbaum, S. R. Structure of the single stable hemoglobin adduct formed by 4-aminobiphenyl in vivo. Chem. Res. Toxicol. 1988, 1, 22-24.
20. Kazanis, S.; McClelland, R. A. Electrophilic intermediate in the reaction of glutathione and nitrosoarenes. J. Am. Chem. Soc. 1992, 114, 3052-3059.
21. Ehrenberg, L.; Hiesche, K. D.; Osterman-Golkar, S.; Weinberg, I. Evaluation of genetic risks of alkylating agents: Tissue doses in the mouse from air contaminated with ethylene oxide. Mutat. Res. 1974, 24, 83-103.
22. Sabbioni, G. Hemoglobin binding of nitroarenes and quantitative structure-activity relationships. Chem. Res. Toxicol. 1994, 7, 267-274.
23. Sabbioni, G.; Sepai, O. Comparison of hemoglobin binding, mutagenicity and carcinogenicity of arylamines and nitroarenes. Chimia 1995, 49, 374-380.
24. Neumann, H. G.; Birner, G.; Kowallik, P.; Schutze, D.; Zwirner-Baier, I. Hemoglobin adducts of N-substituted aryl compounds in exposure control and risk assessment. Environ. Health Perspect. 1993, 99, 65-69.
25. van Welie, R. T. H.; van Dijck, R. G. J. M.; Vermeulen, N. P. E.; van Sittert, N. J. Mercapturic acids, protein adducts, and DNA adducts as biomarkers of electrophilic chemicals. Crit. Rev. Toxicol. 1992, 22, 271-306.
26. Albertini, R. J.; Anderson, D.; Douglas, G. R.; Hagmar, L.; Hemminki, K.; Merlo, F.; Natarajan, A. T.; Norppa, H.; Shuker, D. E. G.; Tice, R.; Waters, M. D.; Aitio, A. IPCS guidelines for the monitoring of genotoxic effects of carcinogens in humans. Mutat. Res. 2000, 463, 111-172.
27. Timbrell, J. A. Biomarkers in toxicology. Toxicology 1998, 129, 1-12.
28. Sabbioni, G.; Beyerbach, A. Determination of hemoglobin adducts of arylamines in humans. J. Chromatogr., B 1995, 667, 75-83.
29. Jones, C. R.; Liu, Y.-Y.; Sepai, O.; Yan, H.; Sabbioni, G. Hemoglobin adducts in workers exposed to nitrotoluenes. Carcinogenesis 2005, 26, 133-143.
30. Tannenbaum, S. R.; Bryant, M. S.; Skipper, P. L.; Maclure, M. Hemoglobin adducts of tobacco-related aromatic amines: application to molecular epidemiology. BanburyRep. 1986, 26, 63-75.
31. Sabbioni, G.; Liu, Y.-Y.; Yan, H.; Sepai, O. Hemoglobin adducts, urinary metabolites, and health effects in 2,4,6-trinitrotoluene exposed workers. Carcinogenesis 2005, 26, 1272-1279.
32. U.S. Environmental Protection Agency. Risk Characterization Handbook; EPA 100-B-00-002; Science Policy Council, U.S. Environmental Protection Agency: Washington, DC, 2000.
33. U.S. Department of Energy-Oak Ridge Operations (DOE-ORO). Guidance for Conducting Risk Assessments and Related Risk Activities for the DOE-ORO Environmental Management Program; BJC/OR-271; Oak Ridge, TN, 1999.
34. Gold, L. S.; Slone, T. H.; Ames, B. N. What do animal cancer tests tell us about human cancer risk? Overview of analyses of the carcinogenic potency database. Drug Metab. Rev. 1998, 30, 359-404.
35. Gold, L. S.; Sawyer, C. B.; Magaw, R.; Backman, G. M.; deVeciana, M.; Levinson, R.; Hooper, N. K.; Havender, W. R.; Bernstein, L., Peto, R.; Pike, M. C.; Ames, B. N. A carcinogenic potency database of the standardized results of animal bioassays. Environ. Health Perspect. 1984, 58, 9-319.
36. Gold, L. S.; Backman, G. M.; Hooper, N. K.; Peto, R. Ranking the potential carcinogenic hazards to workers from exposures to chemicals that are tumorigenic in rodents. Environ. Health Perspect. 1987, 76, 211-219.
37. National Institute for Occupational Safety and Health (NIOSH). Pocket Guide to Chemical Hazards; U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention: Cincinnati, OH, 2001.
38. Bus, J. S.; Popp, J. A. Perspectives on the mechanism of action of the splenic toxicity of aniline and structurally-related compounds. Food Chem. Toxicol. 1987, 25, 619-626.
39. Goldstein, R. S.; Rickert, D. E. Macromolecular covalent binding of [14C] nitrobenzene in the erythrocyte and spleen of rats and mice. Chem.-Biol. Interact. 1984, 50, 27-37.
40. Kiese, M. Methemoglobinemia: A comprehensive treatise; CRC Press Inc.: Cleveland, OH, 1974; pp 1-258.