Ghrelin: A striking example of neuroendocrine peptide pleiotropy;La ghréline, un exemple saisissant de pléïotropie des peptides neuroendocriniens

Medecine/Sciences

Volumn 21, Issue 8-9, 2005, Pages 715-721

  Bluet Pajot, Marie Thérèse ^a   Tolle, Virginie ^a,c   Zizzari, Philippe ^a   Tomasetto, Catherine ^b   Grouselle, Dominique ^a   Epelbaum, Jacques ^a  

^a INSERM   (France)

^b CNRS   (France)

^c OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APPETITE STIMULANT; GHRELIN; GROWTH HORMONE; GROWTH HORMONE SECRETAGOGUE RECEPTOR; GROWTH HORMONE SECRETAGOGUE RECEPTOR 1A; PEPTIDE; SERINE; UNCLASSIFIED DRUG;

ACROMEGALY; ACYLATION; ANOREXIA; APPETITE; CARDIOVASCULAR FUNCTION; ENDOCRINOLOGY; GROWTH HORMONE DEFICIENCY; GROWTH HORMONE RELEASE; HORMONE ACTION; INTERNAL MEDICINE; KNOCKOUT MOUSE; METABOLISM; MOUSE; NEUROENDOCRINE SYSTEM; NONHUMAN; OBESITY; PATHOPHYSIOLOGY; PLEIOTROPY; PRADER WILLI SYNDROME; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW; UNDERWEIGHT;

EID: 30344453673     PISSN: 07670974     EISSN: None     Source Type: Journal    
DOI: 10.1051/medsci/2005218-9715     Document Type: Review

References (51)

1. Kojima M, Hoscda H, Date Y, et al. Ghrelin is a growth hormone-releasing peptide from stomach. Nature 1999, 402: 656-60.
2. Bowers CY, Chang J, Momany FA, et al. Effects of enkephalins and enkephalins analogs on release of pituitary hormones in vitro. In: Mc Intyre I, Szelke M, eds. Molecular endocrinology. Amsterdam: Elsevier, 1977: 287-92.
3. Thorner MO, Chapman IM, Gaylinn BD, et al. Growth hormone-releasing hormone and growth hormone-releasing peptide as therapeutic agents to enhance growth hormone secretion in disease and aging. Recent Prog Horm Res 1997; 52: 215-44.
4. Howard AD, Feighner SD, Cully DF, et al. A receptor in pituitary and hypothalamus that functions in growth hormone release. Science 1996; 273: 974-7.
5. Tullin S, Hansen BS, Ankersen M, et at. Adenosine is an agonist of the growth hormone secretagogue receptor. Endocrinology 2000; 141: 3397-402
6. Tomasetto C, Karam SM, Ribieras S, et al. Identification and characterization of a novel gastric peptide hormone: the motilin-related peptide. Gastroenterology 2000; 119: 395-405.
7. Kojima M, Hosoda H, Kaiya H, et al. Discovery of ghrelin, an endogenous ligand for the growth hormone secretagogue receptor. In: Ghigo E, ed. Ghrelin. Boston: Kluwers, 2004: 15-25.
8. Holst B, Cygankiewicz A, Jensen TH, et al. High constitutive signaling of the ghrelin receptor: identification of a potent inverse agonist. Mol Endocrinol 2003; 17: 2201-10.
9. Broglio F, Arvat E, Benso A, et al. Endocrine activities of cortistatin-14 and its interaction with GHRH and ghrelin in humans. J Clin Endocrinol Metab 2002; 87: 3783-90.
10. Beaumont NJ, Skinner VO, Tan TM, et al. Ghrelin can bind to a species of high density lipoprotein associated with paraoxonase. J Biol Chem 2003; 278: 8877-80.
11. De Vriese C, Gregoire F, Lema-Kisoka R, et al. Ghrelin degradation by serum and tissue homogenates: identification of the cleavage sites. Endocrinology 2004; 145: 4997-5005.
12. Bodart V, Febbraio M, Demers A, et al. CD36 mediates the cardiovascular action of growth hormone-releasing peptides in the heart. Circ Res 2002; 90: 844-9.
13. Frieboes RM, Antonijevic IA, Held K, et al. Hexarelin decreases slow-wave sleep and stimulates the secretion of GH, ACTH, cortisol and prolactin during sleep in healthy volunteers. Psychoneuroendocrinology 2004; 29: 851-60.
14. Wren AM, Seal LJ, Cohen MA, et al. Ghrelin enhances appetite and increases food intake in humans. J Clin Endocrinol Metab 2001; 86: 5992-95.
15. Cowley MA, Smith RG, Diano S, et al. The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis. Neuron 2003; 37: 649-61.
16. Wortley KE, Anderson KD, Garcia K, et al. Genetic deletion of ghrelin does not decrease food intake but influences metabolic fuel preference. Proc Natl Acad Sci USA 2004; 101: 8227-32.
17. Tannenbaum GS, Epelbaum J, Bowers CY. Interrelationship between the novel peptide ghrelin and somatostatin/growth hormone-releasing hormone in regulation of pulsatile growth hormone secretion. Endocrinology 2003; 144: 967-74.
18. Nakazato M, Yurakami N, Date Y, et al. A role for ghrelin in the central regulation of feeding. Nature 2001; 409: 194-8.
19. Tolle V, Zizzari P, Tomasetta C, et al. In vivo and in vitro effects of ghrelin/motilin-related peptide on growth hormone secretion in the rat. Neuroendocrinology 2001; 73: 54-61.
20. Date Y, Murakami N, Toshinai K, et al. The role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion in rats. Gastroenterology 2002; 123: 1120-8.
21. Tschop M, Smiley DL, Heiman ML, et al. Ghrelin induces adiposity in rodents. Nature 2000; 407: 908-13.
22. Thompson NM, Gill DA, Davies R, et al. Ghrelin and des-octanoyl ghrelin promote adipogenesis directly in vivo by a mechanism independent of the type 1a growth hormone secretagogue receptor. Endocrinology 2004; 145: 234-42.
23. Sun Y, Ahmed S, Smith RG. Deletion of ghrelin impairs neither growth nor appetite. Mol Cell Biol 2003; 23: 7973-81.
24. Sun Y, Wang P, Zheng H, Smith RG. Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor. Proc Natl Acad Sci USA 2004; 30: 101: 4679-84
25. Masuda Y, Tanaka T, Inomata N, et al. Ghrelin stimulates gastric acid secretion and motility in rats. Biochem Biophys Res Commun 2000; 276: 905-8.
26. Fujino K, Inui A, Asakawa A, et al. Ghrelin induces fasted motor activity of the gastrointestinal tract in conscious fed rats. J Physiol 2003; 550: 227-40.
27. Trudel L, Tomasetto C, Rio MC, et al. Ghrelin/motilin-related peptide is a potent prokinetic to reverse gastric postoperative ileus in rat. Am J Physiol Gastrointest Liver Physiol 2002; 282: G948-52.
28. Sibilia V, Rindi G, Pagani F, et al. Ghrelin protects against ethanol-induced gastric ulcers in rats: studies on the mechanisms of action. Endocrinology 2003; 144: 353-9.
29. Tatsuguchi A, Miyake K, Gudis K, et al. Effect of Helicobacter pylori infection on ghrelin expression in human gastric mucosa. Am J Gastroenterol 2004; 99: 2121-7.
30. Zhang W, Chen M, Chen X, et al. Inhibition of pancreatic protein secretion by ghrelin in the rat. J Physiol 2001; 537: 231-6.
31. Arosia M, Ronchi CL, Gebbia C, et al. Stimulatory effects of ghrelin on circulating somatostatin and pancreatic polypeptide levels. J Clin Endocrinol Metab 2003; 88: 701-4.
32. Broglio F, Gottero C, Prodam F, et al. Non-acylated ghrelin counteracts the metabolic but not the neuroendocrine response to acylated ghrelin in humans. J Clin Endocrinol Metab 2004; 89: 3062-5.
33. Torsello A, Bresciani E, Rossoni G, et al. Ghrelin plays a minor role in the physiological control of cardiac function in the rat. Endocrinology 2003; 144: 1787-92.
34. Bisi G, Podio V, Valetto MR, et al. Cardiac effects of hexarelin in hypopituitary adults. Eur J Pharmacol 1999; 381: 31-8.
35. Korbonits M, Goldstone AP, Gueorguiev M, et al. Ghrelin. A hormone with multiple functions. Front Neuroendocrinol 2004; 25: 27-68.
36. Iglesias MJ, Pineiro R, Blanco M, et al. Growth hormone releasing peptide (ghrelin) is synthesized and secreted by cardiomyocytes. Cardiovasc Res 2004; 62: 481-8.
37. Tolle V, Bassant MH, Zizzari P, et al. Ultradian rhythmicity of ghrelin secretion in relation with GH, feeding behavior, and sleep-wake patterns in rats. Endocrinology 2002; 143: 1353-61.
38. Corbetta S, Peracchi M, Cappiello V, et al. Circulating ghrelin levels in patients with pancreatic and gastrointestinal neuroendocrine tumors: identification of one pancreatic ghrelinoma. J Clin Endocrinol Metab 2003; 88: 3117-20.
39. Camina JP, Carreira MC, El Messari S, et al. Desensitization and endocytosis mechanisms of ghrelin-activated growth hormone secretagogue receptor 1a. Endocrinology 2004; 145: 930-40.
40. Cummings DE, Frayo RS, Marmonier C, et al. Plasma ghrelin levels and hunger scores in humans initiating meals voluntarily without time- and food-related cues. Am J Physiol Endocrinol Metab 2004; 287: E297-304.
41. Hansen TK, Dall R, Hosoda H, et al. Weight loss increases circulating levels of ghrelin in human obesity. Clin Endocrinol 2002; 56: 203-6
42. Tolle V, Kadem M, Bluet-Pajot MT, et al. Balance in ghrelin and leptin plasma levels in anorexia nervosa patients and constitutionally thin women. J Clin Endocrinol Metab 2003; 88: 109-16.
43. Poykko SM, Kellokoski E, Horkko S, et al. Low plasma ghrelin is associated with insulin resistance, hypertension, and the prevalence of type 2 diabetes. Diabetes 2003; 52: 2546-53.
44. Shiiya T, Nakazato M, Mizuta M, et al. Plasma ghrelin levels in lean and obese humans and the effect of glucose on ghrelin secretion. J Clin Endocrinol Metab 2002; 87: 240-4.
45. Pombo M, Leal-Cerro A, Barreiro J, et al. Growth hormone releasing hexapeptide-6 (GHRP-6) test in the diagnosis of GH-deficiency. J Pediatr Endocrinol Metab 1996; 9: 333-8.
46. Tan TM, Vanderpump M, Khoo B, et al. Somatostatin infusion lowers plasma ghrelin without reducing appetite in adults with Prader-Willi syndrome. J Clin Endocrinol Metab 2004; 89: 4162-5.
47. th Annual meeting of the Endocrine Society. New Orleans: Endocrine Society, 2004: 010-6 (abstract).
48. Ariyasu H, Takaya K, Iwakura H, et al. Transgenic mice overexpressing des-acyl ghrelin show small phenotype. Endocrinology 2005; 146: 355-64.
49. Shuto Y, Shibasaki T, Otagiri A, et al. Hypothalamic growth hormone secretagogue receptor regulates growth hormone secretion, feeding, and adiposity. J Clin Invest 2002; 109: 1429-36.
50. Lall S, Balthasar N, Carmignac D, et al. Physiological studies of transgenic mice overexpressing growth hormone (GH) secretagogue receptor 1A in GH-releasing hormone neurons. Endocrinology 2004; 145: 1602-11.
51. Smith RG, Cheng K, Schoen WR, et al. A nonpeptidyl growth hormone secretagogue. Science 1993; 260: 1640-3.