Inclusion of unaffected sibs increases power in model-free linkage analysis of a behavioral trait

BMC Genetics

Volumn 6, Issue SUPPL.1, 2005, Pages

  Plancoulaine, Sabine ^a   Alcaïs, Alexandre ^a   Chen, Yue ^b   Abel, Laurent ^a   Gagnon, France ^b  

^a INSERM   (France)

^b UNIVERSITY OF OTTAWA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BEHAVIOR DISORDER; BINOMIAL DISTRIBUTION; CONTROLLED STUDY; FAMILY STUDY; GENE LOCATION; GENE LOCUS; GENETIC ANALYSIS; GENETIC CODE; GENETIC CORRELATION; GENETIC LINKAGE; GENETIC TRAIT; HUMAN; INTERMETHOD COMPARISON; LINKAGE ANALYSIS; MAJOR CLINICAL STUDY; MAXIMUM LIKELIHOOD METHOD; MICROSATELLITE MARKER; PHENOTYPE; SIBLING; SINGLE NUCLEOTIDE POLYMORPHISM; WORKSHOP; BEHAVIOR; BIOLOGICAL MODEL; CHROMOSOME MAP; GENETICS; QUANTITATIVE TRAIT;

MICROSATELLITE DNA;

BEHAVIOR; CHROMOSOME MAPPING; HUMANS; LOD SCORE; MICROSATELLITE REPEATS; MODELS, GENETIC; POLYMORPHISM, SINGLE NUCLEOTIDE; QUANTITATIVE TRAIT, HERITABLE; SIBLINGS;

EID: 30344450706     PISSN: None     EISSN: 14712156     Source Type: Journal    
DOI: 10.1186/1471-2156-6-S1-S22     Document Type: Article

References (8)

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5. Majumder PP, Pal N: Nonrandom segregation: uniformly most powerful test and related considerations. Genet Epidemiol 1987, 4:277-287.
6. Abel L, Alcaids A, Mallet A: Comparison of four sib-pair linkage methods for analyzing sibships with more than two affecteds: interest of the binomial maximum likelihood approach. Genet Epidemiol 1998, 15:371-390.
7. Alcaïs A, Abel L: Maximum-likelihood-binomial method for genetic model-free linkage analysis of quantitative traits in sibships. Genet Epidemiol 1999, 17:102-117.
8. Alacïs A, Philippi A, Abel L: Genetic model-free linkage analysis using the maximum-likelihood-binomial method for categorical traits. Genet Epidemiol 1999, 17(Suppl 1):S467-S472.