Activation of phospholipase A2 is associated with generation of placental lipid signals and fetal obesity

Journal of Clinical Endocrinology and Metabolism

Volumn 91, Issue 1, 2006, Pages 248-255

  Varastehpour, Ali ^a   Radaelli, Tatjana ^a   Minium, Judi ^a   Ortega, Henar ^b   Herrera, Emilio ^b   Catalano, Patrick ^a   Hauguel de Mouzon, Sylvie ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSIDAD SAN PABLO CEU   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID; LEPTIN; LIPID; OMEGA 3 FATTY ACID; PHOSPHOLIPASE A2; TUMOR NECROSIS FACTOR ALPHA;

ANTHROPOMETRY; ARTICLE; BIOLOGY; BODY FAT; CESAREAN SECTION; COMPARATIVE STUDY; CONTROLLED STUDY; ENZYME ACTIVATION; FEMALE; FETUS; HUMAN; HUMAN CELL; HUMAN TISSUE; INFORMED CONSENT; LIPID STORAGE; NEWBORN; NUCLEOTIDE SEQUENCE; OBESITY; PLACENTA; PRACTICE GUIDELINE; PREGNANCY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REPRODUCTION; UNIVERSITY;

ADULT; CELL SEPARATION; CELLS, CULTURED; ENZYME ACTIVATION; FATTY ACIDS, OMEGA-3; FATTY ACIDS, OMEGA-6; FEMALE; FETAL DISEASES; HUMANS; INFANT, NEWBORN; LEPTIN; LIPIDS; OBESITY; PHOSPHOLIPASES A; PLACENTA; PREGNANCY; RNA; TUMOR NECROSIS FACTOR-ALPHA;

EID: 30344447530     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2005-0873     Document Type: Article

References (48)

1. Ravelli GP, Stein ZA, Susser MW 1976 Obesity in young men after famine exposure in utero and early infancy. N Engl J Med 295:349-353
2. Hales C, Barker D 1992 Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis. Diabetologia 35:595-601
3. Silverman BL, Rizzo TA, Cho NH, Metzger BE 1998 Long-term effects of the intrauterine environment. The Northwestern University Diabetes in Pregnancy Center. Diabetes Care 21(Suppl 2):B142-B149
4. Catalano P, Drago N, Amini S 1995 Factors affecting fetal growth and body composition. Am J Obstet Gynecol 172:1459-1463
5. Aalinkeel R, Srinivasan M, Song F, Patel M 2001 Programming into adulthood of islet adaptations induced by early nutritional intervention in the rat. Am J Physiol Endocrinol Metab 281:E640-E648
6. Boloker J, Gertz S, Simmons RA 2002 Gestational diabetes leads to the development of diabetes in adulthood in the rat. Diabetes 51:1499-1506
7. Durnwald C, Huston-Presley L, Amini S, Catalano P 2004 Evaluation of body composition of large for gestational age infants of women with gestational diabetes compared with women with normal glucose tolerance. Am J Obstet Gynecol 191:804-808
8. Catalano P, Thomas A, Huston-Presley L, Amini S 2003 Increased fetal adiposity: a very sensitive marker of abnormal in utero development. Am J Obstet Gynecol 189:1698-1704
9. Radaelli T, Varastehpour A, Catalano P, Hauguel-de Mouzon S 2003 Gestational diabetes induces placental genes for chronic stress and inflammatory pathways. Diabetes 52:2951-2958
10. Kirwan J, Hauguel-de Mouzon S, Lepercq J, Challier J, Huston-Presley L, Friedman J, Kalhan S, Catalano P 2002 TNF-α is a primary mediator of insulin resistance in human pregnancy. Diabetes 51:2207-2213
11. Coughlan MT, Oliva K, Georgiou HM, Permezel JM, Rice GE 2001 Glucose-induced release of tumour necrosis factor-α from human placental and adipose tissues in gestational diabetes mellitus. Diabet Med 11:921-927
12. Xu H, Barnes G, Yang Q, Tan G, Yang D, Chou C, Sole J, Nichols A, Ross J, Tartaglia L, Chen H 2003 Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest 112:1821-1830
13. Matarese G, La Cava A 2004 The intricate interface between immune system and metabolism. Trends Immunol 25:193-200
14. Lappas M, Permezel M, Georgiou HM, Rice GE 2001 Type II phospholipase A2 in preterm human gestational tissues. Placenta 22:64-69
15. Lappas M, Rice GE 2004 Phospholipase A2 isozymes in pregnancy and parturition. Prostaglandins Leukot Essent Fatty Acids 70:87-100
16. Oka S, Arita H 1991 Inflammatory factors stimulate expression of group II phospholipase A2 in rat cultured astrocytes. Two distinct pathways of the gene expression. J Biol Chem 266:9956-9960
17. Konieczkowski M, Sedor J 1993 Cell-specific regulation of type II phospholipase A2 expression in rat mesangial cells. J Clin Invest 92:2524-2532
18. Chirgwin JM, Przybyla AE, McDonald RJ, Rutter WJ 1979 Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 18:5294-5299
19. Kliman HJ, Nestler JE, Sermasi E, Sanger JM, Strauss III JF 1986 Purification, characterization and in vitro differentiation of cytotrophoblasts from human term placentae. Endocrinology 118:1567-1582
20. Phillips T, Ni J, Hunt J 2001 Death-inducing tumor necrosis factor (TNF) superfamily ligands and receptors are transcribed in human placentae, cytotrophoblasts, placental macrophages and placental cell lines. Placenta 22:663-672
21. Folch J, Lees M, Sloane Stanley GH 1957 A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 22:24-36
22. Amusquivar E, Herrera E 2003 Influence of changes in dietary fatty acids during pregnancy on placental and fetal fatty acid profile in the rat. Biol Neonate 83:136-145
23. Lepage G, Roy C 1986 Direct transesterification of all classes of lipids in one-step reaction. J Lipid Res 27:114-120
24. Hotamisligil G, Shargill N, Spiegelman B 1993 Adipose expression of tumor necrosis factor-α: direct role in obesity-linked insulin resistance. Science 259:87-91
25. Kern P, Saghizadeh M, Ong J, Bosch R, Deem R, Simsolo R 1995 The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase. J Clin Invest 95:2111-2119
26. Mantzoros C, Moschos S, Avramopoulos I, Kaklamani V, Liolios A, Doulgerakis D, Griveas I, Katsilambros N, Flier J 1997 Leptin concentrations in relation to body mass index and the tumor necrosis factor-α system in humans. J Clin Endocrinol Metab 82:3408-3413
27. Lepercq J, Guerre-Millo M, Vidal H, Cauzac M, Timsit J, Hauguel-de Mouzon S 2001 Prenatal leptin production: evidence that fetal adipose tissue produces leptin. J Clin Endocrinol Metab 86:2409-2413
28. Cauzac M, Czuba D, Girard J, Hauguel-de Mouzon S 2003 Transduction of leptin growth signals in placental cells is independent of JAK-STAT activation. Placenta 24:378-384
29. 2 regulation of arachidonic acid mobilization. FEBS Lett 531:2-6
30. Dennis E 1994 Diversity of group types, regulation, and function of phospholipase A2. J Biol Chem 269:13057-13060
31. 2 group IIA on lipoproteins and in atherogenesis. Eur J Clin Invest 32:381-382
32. Freed K, Moses E, Brennecke S, Rice G 1997 Differential expression of type II, IV and cytosolic PLA2 mRNA in human intrauterine tissues at term. Mol Hum Reprod 3:493-499
33. Farrugia W, Rice G, Wong M, Scott K, Brennecke S 1997 Release of type II phospholipase A2 immunoreactivity and phospholipase A2 enzymatic activity from human placenta. J Endocrinol 153:151-157
34. Crawford M 2000 Placental delivery of arachidonic and docosahexaenoic acids: implications for the lipid nutrition of preterm infants. Am J Clin Nutr 71:275S-284S
35. Matorras R, Lopez De Larrucea A, Sanjurjo P, Ignacio Ruiz J, Echevarria Y, Nieto A, Perteagudo L, Aldamiz-Echevarria J 2001 Increased tissue concentrations of arachidonic acid in umbilical artery and placenta in fetal growth retardation. Acta Obstet Gynecol Scand 80:807-812
36. Kuhn D, Botti J, Cherouny P, Demers L 1990 Eicosanoid production and transfer in placenta of the diabetic pregnancy. Prostaglandins 40:205-214
37. 2 enzymes: classification and characterization. Biochim Biophys Acta 1488:1-19
38. Fonteh A, Samet J, Surette M, Reed W, Chilton F 1998 Mechanisms that account for the selective release of arachidonic acid from intact cells by secretory phospholipase A2. Biophys Biochem Acta 393:253-266
39. Tracey K, Cerami A 1993 Tumor necrosis factor, other cytokines and disease. Annu Rev Cell Biol 9:317-343
40. Loffreda S, Yang SQ, Lin HZ, Karp CL, Brengman ML, Wang DJ, Klein AS, Bulkley GB, Bao C, Noble PW, Lane MD, Diehl AM 1998 Leptin regulates proinflammatory immune responses. FASEB J 12:57-65
41. Lepercq J, Caüzac M, Lahlou J, Timsit J, Girard J, Auwerx J, Hauguel-de Mouzon S 1998 Overexpression of placental leptin in diabetic pregnancies: a critical role for insulin. Diabetes 47:847-850
42. Mancuso P, Canetti C, Gottschalk A, Tithof PK, Peters-Golden M 2004 Leptin augments alveolar macrophage leukotriene synthesis by increasing phospholipase activity and enhancing group IVC iPLA2 (cPLA2γ) protein expression. Am J Physiol Lung Cell Mol Physiol 287:L497-L502
43. Beck S, Lambeau G, Scholz-Pedretti K, Gelb MH, Janssen MJ, Edwards SH, Wilton DC, Pfeilschifter J, Kaszkin M 2003 Potentiation of tumor necrosis factor-α-induced secreted phospholipase A2 (sPLA2)-IIA expression in mesangial cells by an autocrine loop involving sPLA2 and peroxisome proliferator-activated receptor-α activation. J Biol Chem 278:29799-29812
44. Miyashita A, Crystal RG, Hay JG 1995 Identification of a 27 bp 5′-flanking region element responsible for the low level constitutive expression of the human cytosolic phospholipase A2 gene. Nucleic Acids Res 23:293-301
45. Sen A, Ghosh PK, Mukherjea M 1998 Changes in lipid composition and fluidity of human placental basal membrane and modulation of bilayer protein functions with progress of gestation. Mol Cell Biochem 187:183-190
46. Kuhn D, Crawford M, Stuart M, Botti J, Demers L 1990 Alterations in transfer and lipid distribution of arachidonic acid in placenta of diabetic pregnancies. Diabetes 39:914-918
47. Huggins KW, Boileau AC, Hui DY 2002 Protection against diet-induced obesity and obesity-related insulin resistance in group 1B PLA2-deficient mice. Am J Physiol Endocrinol Metab 283:E994-E1001
48. Wolford JK, Konheim YL, Colligan PB, Bogardus C 2003 Association of a F479L variant in the cytosolic phospholipase A2 gene (PLA2G4A) with decreased glucose turnover and oxidation rates in Pima Indians. Mol Genet Metab 79:61-66