NF-κB in tracheal lavage fluid from intubated premature infants: Association with inflammation, oxygen, and outcome

Archives of Disease in Childhood: Fetal and Neonatal Edition

Volumn 91, Issue 1, 2006, Pages

  Bourbia, A ^b   Cruz, M A ^b   Rozycki, H J ^a,b  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 8; OXYGEN; SECRETORY COMPONENT; TRANSCRIPTION FACTOR; BIOLOGICAL MARKER;

ARTICLE; BIRTH WEIGHT; CELL COUNT; CLINICAL ARTICLE; CONCENTRATION (PARAMETERS); CYTOKINE PRODUCTION; DILUTION; EXPOSURE; GESTATIONAL AGE; HUMAN; HUMAN CELL; INFLAMMATION; INTUBATION; LUNG DYSPLASIA; NEWBORN; NEWBORN INTENSIVE CARE; OXYGEN BREATHING; PATHOGENESIS; PREMATURITY; PRIORITY JOURNAL; RISK FACTOR; TRACHEOBRONCHIAL TOILET; TREATMENT OUTCOME; CHEMISTRY; ENDOTRACHEAL INTUBATION; LEUKOCYTE COUNT; LUNG LAVAGE; METABOLISM; OXYGEN THERAPY; PNEUMONIA; PROGNOSIS; TRACHEA; VERY LOW BIRTH WEIGHT;

BIOLOGICAL MARKERS; BIRTH WEIGHT; BRONCHOALVEOLAR LAVAGE FLUID; BRONCHOPULMONARY DYSPLASIA; GESTATIONAL AGE; HUMANS; INFANT, NEWBORN; INFANT, PREMATURE; INFANT, VERY LOW BIRTH WEIGHT; INTERLEUKIN-8; INTUBATION, INTRATRACHEAL; LEUKOCYTE COUNT; NF-KAPPA B; OXYGEN INHALATION THERAPY; PNEUMONIA; PROGNOSIS; TRACHEA;

EID: 30344441809     PISSN: 13592998     EISSN: 14682052     Source Type: Journal    
DOI: 10.1136/adc.2003.045807     Document Type: Article

References (26)

1. Speer CP. New insights into the pathogenesis of pulmonary inflammation in preterm infants. Biol Neonate 2001;79:205-9.
2. Rozycki HJ. Bronchoalveolar interleukin-1 beta in infants on day 1 of life. South Med J 1994;87:991-6.
3. Bagchi A, Viscardi RM, Taciak V, et al. Increased activity of interleukin-6 but not tumor necrosis factor-alpha in lung lavage of premature infants is associated with the development of bronchopulmonary dysplasia. Pediatr Res 1994;36:244-52.
4. Baier RJ, Loggins J, Kruger TE. Monocyte chemoattractant protein-1 and interleukin-8 are increased in bronchopulmonary dysplasia: relation to isolation of Ureaplasma urealyticum. J Investig Med 2001;49:362-9.
5. Ramsay PL, O'Brian Smith E, Hegemier S, et al. Early clinical markers for the development of bronchopulmonary dysplasia: soluble E-Selectin and ICAM-1. Pediatrics 1998;102:927-32.
6. Fan J, Ye RD, Malik AB. Transcriptional mechanisms of acute lung injury. Am J Physiol Lung Cell Mol Physiol 2001;281:L1037-50.
7. Rothwarf DM, Karin M. The NF-kappa B activation pathway: a paradigm in information transfer from membrane to nucleus. Sci STKE 1999:RE1.
8. Uhlig U, Haitsma JJ, Goldmann T, et al. Ventilation-induced activation of the mitogen-activated protein kinase pathway. Eur Respir J 2002;20:946-56.
9. Li X, Stark GR. NFkappaB-dependent signaling pathways. Exp Hematol 2002;30:285-96.
10. Muraoka RS, Bushdid PB, Brantley DM, et al. Mesenchymal expression of nuclear factor-kappa B inhibits epithelial growth and branching in the embryonic chick lung. Dev Biol 2000;225:322-38.
11. Schwartz MD, Moore EE, Moore FA, et al. Nuclear factor-kappa B is activated in alveolar macrophages from patients with acute respiratory distress syndrome. Crit Care Med 1996;24:1285-92.
12. Paterson RL, Galley HF, Dhillon JK, et al. Increased nuclear factor kappa B activation in critically ill patients who die. Crit Care Med 2000;28:1047-51.
13. Dargaville PA, South M, Vervaart P, et al. Pulmonary surfactant concentration during transition from high frequency oscillation to conventional mechanical ventilation. J Paediatr Child Health 1997;33:517-21.
14. Fisher AB, Al-Mehdi AB, Manevich Y. Shear stress and endothelial cell activation. Crit Care Med 2002;30:S192-7.
15. Rozycki HJ, Eischied AC, Huff TR. Effect of hyperoxia on IL-8 expression in premature versus term rabbit lung explants. Exp Lung Res 2004;30:285-96.
16. D'Angio CT, Finkelstein JN. Oxygen regulation of gene expression: a study in opposites. Mol Genet Metab 2000;71:371-80.
17. Churg A, Wright JL. Airway wall remodeling induced by occupational mineral dusts and air pollutant particles. Chest 2002;122:306S-309S.
18. Li Q, Verma IM. NF-kappaB regulation in the immune system. Nat Rev Immunol 2002;2:725-34.
19. Tullus K, Noack GW, Burman LG, et al. Elevated cytokine levels in tracheobronchial aspirate fluids from ventilator treated neonates with bronchopulmonary dysplasia. Eur J Pediatr 1996;155:112-16.
20. Held HD, Boettcher S, Hamann L, et al. Ventilation-induced chemokine and cytokine release is associated with activation of nuclear factor-kappaB and is blocked by steroids. Am J Respir Crit Care Med 2001;163:711-16.
21. Di Stefano A, Caramori G, Oates T, et al. Increased expression of nuclear factor-kappaB in bronchial biopsies from smokers and patients with COPD. Eur Respir J 2002;20:556-63.
22. Farver CF, Raychaudhuri B, Malur A, et al. Increased alveolar macrophage nuclear factor-kappa B activation and macrophage inhibitory protein-1alpha levels in lung transplant patients. Transplantation 2000;70:1599-603.
23. Hart LA, Krishnan VL, Adcock IM, et al. Activation and localization of transcription factor, nuclear factor-kappaB, in asthma. Am J Respir Crit Care Med 1998;158:1585-92.
24. Uhlig U, Fehrenbach H, Lachmann RA, et al. Phosphoinositide 3-OH kinase inhibition prevents ventilation-induced lung cell activation. Am J Respir Crit Care Med 2004;169:201-08.
25. Sadikot RT, Han W, Everhart MB, et al. Selective IkappaB kinase expression in airway epithelium generates neutrophilic lung inflammation. J Immunol 2003;170:1091-8.
26. Griesenbach U, Scheid P, Hillery E, et al. Anti-inflammatory gene therapy directed at the airway epithelium. Gene Ther 2000;7:306-13.