Analysis of correlation between serum d-serine levels and functional promoter polymorphisms of GRIN2A and GRIN2B genes

Neuroscience Letters

Volumn 394, Issue 2, 2006, Pages 101-104

  Iwayama, Yoshimi ^a   Hashimoto, Kenji ^b   Nakajima, Mizuho ^a,c   Toyota, Tomoko ^a   Yamada, Kazuo ^a   Shimizu, Eiji ^b   Itokawa, Masanari ^d   Hoshika, Akinori ^c   Iyo, Masaomi ^b   Yoshikawa, Takeo ^a,e  

^a RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

^b CHIBA UNIVERSITY   (Japan)

^c TOKYO MEDICAL UNIVERSITY HOSPITAL   (Japan)

^d TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

^e JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

NMDA receptor; NR2A subunit; NR2B subunit; Schizophrenia; Short tandem repeat; SNP

Indexed keywords

DEXTRO SERINE; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2A; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B;

ADULT; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; GENE EXPRESSION; GENETIC ANALYSIS; GENETIC POLYMORPHISM; GENETIC TRANSCRIPTION; GENOTYPE; GENOTYPE PHENOTYPE CORRELATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; NEUROTRANSMISSION; PRIORITY JOURNAL; PROMOTER REGION; SCHIZOPHRENIA; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COHORT STUDIES; FEMALE; GENE FREQUENCY; GENOTYPE; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; PROMOTER REGIONS (GENETICS); PROTEIN SUBUNITS; RECEPTORS, N-METHYL-D-ASPARTATE; SCHIZOPHRENIA; SERINE; STATISTICS;

EID: 30344437921     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2005.10.025     Document Type: Article

References (15)

1. American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders fourth ed. 1994 American Psychiatric Press Washington, DC
2. O. Andersson, A. Stenqvist, A. Attersand, and G. von Euler Nucleotide sequence, genomic organization, and chromosomal localization of genes encoding the human NMDA receptor subunits NR3A and NR3B Genomics 78 2001 178 184
3. W. Danysz, and A.C. Parsons Glycine and N-methyl-d-aspartate receptors: physiological significance and possible therapeutic applications Pharmacol. Rev. 50 1998 597 664
4. T. Fukushima, J. Kawai, K. Imai, and T. Toyo'oka Simultaneous determination of d- and l-serine in rat brain microdialysis sample using a column-switching HPLC with fluorimetric detection Biomed. Chromatogr. 18 2004 813 819
5. K. Hashimoto, T. Fukushima, E. Shimizu, N. Komatsu, H. Watanabe, N. Shinoda, M. Nakazato, C. Kumakiri, S. Okada, H. Hasegawa, K. Imai, and M. Iyo Decreased serum levels of d-serine in patients with schizophrenia: evidence in support of the N-methyl-d-aspartate receptor hypofunction hypothesis of schizophrenia Arch. Gen. Psychiatry 60 2003 572 576
6. A. Hashimoto, T. Nishikawa, T. Hayashi, N. Fujii, K. Harada, T. Oka, and K. Takahashi The presence of free d-serine in rat brain FEBS Lett. 296 1992 33 36
7. M. Itokawa, K. Yamada, K. Yoshitsugu, T. Toyota, T. Suga, H. Ohba, A. Watanabe, E. Hattori, H. Shimizu, T. Kumakura, M. Ebihara, J.M.A. Meerabux, M. Toru, and T. Yoshikawa A microsatellite repeat in the promoter of the N-methyl d-aspartate receptor 2A subunit (GRIN2A) gene suppresses transcriptional activity and correlates with chronic outcome in schizophrenia Pharmacogenetics 13 2003 271 278
8. n polymorphism in the GRIN2A promoter with Japanese schizophrenia Neurosci. Lett. 378 2005 102 105
9. D.C. Javitt, and S.R. Zukin Recent advances in the phencyclidine model of schizophrenia Am. J. Psychiatry 148 1991 1301 1308
10. J.H. Krystal, D.C. D'Souza, I.L. Petrakis, A. Belger, R. Berman, D.S. Charney, W. Abi-Saab, and S. Madonick NMDA agonists and antagonists as probes of glutamatergic dysfunction and pharmacotherapies for neuropsychiatric disorders Harv. Rev. Psychiatry 7 1999 125 133
11. P.D. Leeson, and L.L. Iversen The glycine site on the NMDA receptor: structure-activity relationships and therapeutic potential J. Med. Chem. 37 1994 4053 4067
12. R. Miyatake, A. Furukawa, and H. Suwaki Identification of a novel variant of the human NR2B gene promoter region and its possible association with schizophrenia Mol. Psychiatry 7 2002 1101 1106
13. B. Scatton The NMDA receptor complex Fundam. Clin. Pharmacol. 7 1993 389 400
14. S.H. Snyder, and C.D. Ferris Novel neurotransmitters and their neuropsychiatric relevance Am. J. Psychiatry 157 2000 1738 1751
15. K. Yamada, T. Ohnishi, K. Hashimoto, H. Ohba, Y. Iwayama-Shigeno, M. Toyoshima, A. Okuno, H. Takao, T. Toyota, Y. Minabe, K. Nakamura, E. Shimizu, M. Itokawa, N. Mori, M. Iyo, and T. Yoshikawa Identification of multiple serine racemase (SRR) mRNA isoforms and genetic analyses of SRR and DAO in schizophrenia and d-serine levels Biol. Psychiatry 57 2005 1493 1503