Ketotifen improves sperm motility and sperm morphology in male patients with leukocytospermia and unexplained infertility

Fertility and Sterility

Volumn 85, Issue 1, 2006, Pages 240-243

  Oliva, Alejandro ^a   Multigner, Luc ^b,c  

^a HOSPITAL ITALIANO DE BUENOS AIRES   (Argentina)

^b INSERM   (France)

^c UNIVERSITÉ DE RENNES 1   (France)

Author keywords

[No Author keywords available]

Indexed keywords

KETOTIFEN;

ADULT; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; HUMAN; LEUKOCYTE COUNT; LEUKOCYTE DISORDER; LEUKOCYTOSPERMIA; MAJOR CLINICAL STUDY; MALE; MALE INFERTILITY; MORPHOLOGY; PRIORITY JOURNAL; SEMEN ABNORMALITY; SEMEN ANALYSIS; SEMINAL PLASMA; SPERMATOZOON MOTILITY;

ADULT; HISTAMINE H1 ANTAGONISTS; HUMANS; INFERTILITY, MALE; KETOTIFEN; LEUKOCYTE COUNT; MALE; MIDDLE AGED; SPERM MOTILITY; SPERMATOZOA;

EID: 30344434060     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2005.06.047     Document Type: Article

References (27)

1. M.I.M. El-Demiry, T.B. Hargreave, A. Busuttil, R. Elton, K. James, G.D. Chisholm Immunocompetent cells in human testis in health and disease Fertil Steril 48 1987 470 479
2. M.J. Tomlinson, A. White, C.L. Barrat, A.E. Bolton, I.D. Cooke The removal of morphologically abnormal sperm forms by phagocytes a positive role for seminal leukocytes? Hum Reprod 7 1992 517 522
3. H. Wolff The biologic significance of white blood cells in semen Fertil Steril 63 1995 1143 1157
4. World Health Organization WHO laboratory manual for the examination of human semen and semen-cervical mucus interaction 1992 Cambridge University Press Cambridge
5. J.W. Trum, B.W. Mol, Y. Pannekoek, L. Spanjaard, P. Wertheim, O.P. Bleker Value of detecting leukocytospermia in the diagnosis of genital tract infection in subfertile men Fertil Steril 70 1998 315 319
6. J.F. Sedor, I.H. Hirsh Evaluation of sperm morphology of electroejaculates of spinal cord injured men by strict criteria Arch Phys Med Rehabil 83 2002 31 34
7. D.J. Anderson Cell-mediated immunity and inflammatory processes in male infertility Arch Immunol Ther Exp (Warsz) 38 1990 79 86
8. S.M. Curi, J.I. Ariagno, P.H. Chenlo, G.R. Mendeluk, M.N. Pugliese, L.M. Sardi Segovia Asthenozoospermia analysis of a large population Arch Androl 49 2003 343 349
9. M.J. Tomlinson, C.L. Barrat, I.D. Cooke Prospective study of leukocytes and leukocyte subpopulation in semen suggests they are not a cause of male infertility Fertil Steril 60 1993 1069 1075
10. M.I.M. El-Demiry, H. Young, R. Elton, T.B. Hargreave, K. James, G.D. Chisholm Leukocytes in the ejaculates from fertile and infertile men Br J Urol 58 1986 715 720
11. E.H. Yanushpolsky, J.A. Politch, J.A. Hill, D.J. Anderson Is leukocytospermia clinically relevant? Fertil Steril 66 1996 822 825
12. G. Arata de Bellabarba, I. Tortero, V. Villarroel, C.Z. Molina, C. Bellabarba, E. Velazquez Nonsperm cells in human semen and their relationship with semen parameters Arch Androl 45 2000 131 136
13. H. Wolff, J.A. Politch, A. Martinez, F. Haimovici, J.A. Hill, D.J. Anderson Leukocytospermia is associated with poor semen quality Fertil Steril 53 1990 528 536
14. N. Aziz, A. Agarwal, I. Iwan Lewis-Jones, R.K. Sharma, A.J. Thomas Jr Novel associations between specific sperm morphological defects and leukocytospermia Fertil Steril 82 2004 621 627
15. M. Vicino, G. Loverro, S. Simonetti, L. Mei, L. Selvaggi The correlation between idiopathic leukocytospermia, embryo quality and outcome in the FIVET and ICSI procedures Minerva Ginecol 51 1999 413 420
16. D. Sanocka, P. Jedrzejczak, A. Szumala-Kaekol, M. Fraczek, M. Kurpisz Male genital tract inflammation the role of selected interleukins in regulation of pro-oxidant and antioxidant enzymatic substances in seminal plasma J Androl 24 2003 448 455
17. M. Maegawa, M. Kamada, M. Irahara, S. Yamamoto, S. Yoshikawa, Y. Kasai A repertoire of cytokines in human seminal plasma J Reprod Immunol 54 2002 33 42
18. K. Whittington, W.C. Ford Relative contribution of leukocytes and of spermatozoa to reactive oxygen species production in human sperm suspensions Int J Androl 22 1999 229 235
19. R.K. Sharma, A.E. Pasqualotto, D.R. Nelson, A.J. Thomas, A. Agarwal Relationship between seminal white blood cell counts and oxidative stress in men treated at an infertility clinic J Androl 22 2001 575 583
20. J.G. Alvarez, R.K. Sharma, M. Ollero, R.A. Saleh, M.C. Lopez, A.J. Thomas Jr Increased DNA damage in sperm from leukocytospermic semen samples as determined by the sperm chromatin structure assay Fertil Steril 78 2002 319 329
21. E. Vicari Effectiveness and limits of antimicrobial treatment on seminal leukocyte concentration and related reactive oxygen species production in patients with male accessory gland infection Hum Reprod 15 2000 2536 2544
22. C.T. Erel, L.M. Senturk, F. Demir, T. Irez, E. Ertungealp Antibiotic therapy in men with leukocytospermia Int J Fertil Womens Med 42 1997 206 210
23. N. Kondo, O. Fukutomi, T. Kameyama, T. Nishida, G.P. Li, H. Agata Suppression of proliferative responses of lymphocytes to food antigens by an anti-allergic drug, ketotifen fumarate, in patients with food-sensitive atopic dermatitis Int Arch Allergy Immunol 103 1994 234 238
24. J.W. Slater, A.D. Zechnich, D.G. Haxby Second-generation antihistamines a comparative review Drugs 57 1999 31 47
25. R. Paschke, D. Schulze Bertelsbeck, S. Bahrs, A. Heinecke, H.M. Behre Seminal sperm antibodies exhibit an unstable spontaneous course and an increased incidence of leucocytospermia Int J Androl 17 1994 135 139
26. W.B. Schill, J. Schneider, J. Ring The use of ketotifen, a mast cell blocker, for treatment of oligo- and asthenozoospermia Andrologia 18 1986 570 573
27. S. Cayan, D.D. Apa, E. Akbay Effect of fexofenadine, a mast cell blocker, in infertile men with significantly increased testicular mast cells Asian J Androl 4 2002 291 294