Tyrphostin-A47 inhibitable tyrosine phosphorylation of flagellar proteins is associated with distinct alteration of motility pattern in hamster spermatozoa

Molecular Reproduction and Development

Volumn 73, Issue 2, 2006, Pages 215-225

  Mariappa, Daniel ^a   Siva, Archana B ^b   Shivaji, Sisinthy ^b   Seshagiri, Polani B ^a  

^a INDIAN INSTITUTE OF SCIENCE   (India)

^b CENTRE FOR CELLULAR AND MOLECULAR BIOLOGY   (India)

Author keywords

Capacitation; Spermatozoa (hamster); Tyrosine phosphorylation; Tyrphostin A47

Indexed keywords

CELL PROTEIN; DETERGENT; FLAGELLAR PROTEIN; PROTEIN TYROSINE KINASE INHIBITOR; TYRPHOSTIN; TYRPHOSTIN A47; UNCLASSIFIED DRUG;

ACROSOME REACTION; ANIMAL CELL; ARTICLE; CELL STRAIN 3T3; CONTROLLED STUDY; FERTILIZATION; FLAGELLUM; HAMSTER; KINEMATICS; MALE; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SPERMATOZOON CAPACITATION; SPERMATOZOON MOTILITY;

ANIMALS; CELLS, CULTURED; COMPUTER SIMULATION; CRICETINAE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; FLAGELLA; MALE; PHOSPHORYLATION; SPERM MOTILITY; SPERMATOZOA; TIME FACTORS; TYROSINE; TYRPHOSTINS;

ANIMALIA; CRICETINAE; MAMMALIA;

EID: 30144436258     PISSN: 1040452X     EISSN: None     Source Type: Journal    
DOI: 10.1002/mrd.20384     Document Type: Article

References (41)

1. Ain R, Umadevi K, Shivaji S, Seshagiri PB. 1999. Pentoxifylline- stimulated capacitation and acrosome reaction in hamster spermatozoa: Involvement of intracellular signalling molecules. Mol Hum Reprod 5:618-626.
2. Aitken EJ, Harkiss D, Knox W, Paterson M, Irvine DS. 1998. A novel signal transduction cascade in capacitating human spermatozoa characterised by a redox regulated, cAMP-mediated induction of tyrosine phosphorylation. J Cell Sci 111:645-656.
3. Bavister BD, Andrews JC. 1988. A rapid sperm motility bioassay procedure for quality-control testing of water and culture media. J In Vitro Fertil Embryo Transfer 5:67-75.
4. Carrera A, Moss J, Ning XP, Gerton GL, Tesarik J, Kopf GS, Moss SB. 1996. Regulation of protein tyrosine phosphorylation in human sperm by a calcium/calmodulin dependent mechanism: Identification of A kinase anchor proteins as major substrates for tyrosine phosphorylation. Dev Biol 180:284-296.
5. Cheiffi P, Barchi M, Agostino SD, Rossi P, Tramontano D, Geremia R. 2003. Proline-rich tyrosine kinase 2 (PYK2) expression and localization in mouse testis. Mol Reprod Dev 65:330-335.
6. - cotransporter in mouse sperm capacitation. J Biol Chem 278:7001-7009.
7. Devi LG, Shivaji S. 1994. Computerized analysis of the motility parameters of hamster spermatozoa during maturation. Mol Reprod Dev 38:94-106.
8. 2+-adenosine triphosphatases. Biol Reprod 67:1538-1545.
9. Fawcett DW. 1975. The mammalian spermatozoon. Dev Biol 44:394-436.
10. Ficarro S, Chertihin O, Westbrook VA, White F, Jayes F, Kalab P, Marto JA, Shabanowitz J, Herr JC, Hunt DF, Visconti PE. 2003. Phosphoproteome analysis of capacitated human sperm. Evidence of tyrosine phosphorylation of a kinase-anchoring protein 3 and valosin-containing protein/p97 during capacitation. J Biol Chem 278:11579-11589.
11. Harayama H, Muroga M, Miyake M. 2004. A cyclic adenosine 3′, 5′ monophosphate-induced tyrosine phosphorylation of Syk protein tyrosine kinase in the flagella of boar spermatozoa. Mol Reprod Dev 69:436-447.
12. Jayaprakash D, Kumar KS, Shivaji S, Seshagiri PB. 1997. Pentoxifylline induces hyperactivation and acrosome reaction in spermatozoa of golden hamster: Changes in motility kinematics. Hum Reprod 12:2192-2199.
13. Jeulin C, Lewin LM, Chevrier C, Schoevaert-Brossault D. 1996. Changes in flagellar movement of rat spermatozoa along the length of the epididymis: Manual and computer-aided image analysis. Cell Motil Cyto 35:147-161.
14. Jha KN, Shivaji S. 2002. Identification of the major tyrosine phosphorylated protein of capacitated hamster spermatozoa as a homologue of mammalian sperm a kinase anchoring protein. Mol Reprod Dev 61:258-270.
15. Jha KN, Kameshwari DB, Shivaji S. 2003. Role of signaling pathways in regulating the capacitation of mammalian spermatozoa. Cell Mol Biol (Noisy-le-grand) 49:329-340.
16. Kovalenko M, Ronnstrand L, Heldin C, Loubtchenkkov M, Gazit A, Levitzki A, Bohmer FD. 1997. Phosphorylation site-specific inhibition of platelet-derived growth factor β-receptor autophosphorylation by the receptor blocking tyrphostin AG1296. Biochem 36:6260-6269.
17. Kulanand J, Shivaji S. 2001. Capacitation-associated changes in protein tyrosine phosphorylation, hyperactivation and acrosome reaction in hamster spermatozoa. Andrologia 33:95-104.
18. Laemmli UK. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685.
19. 2+. Biol Reprod 67:301-307.
20. Leclerc P, de Lamirande E, Gagnon C. 1996. Cyclic adenosine 3′, 5′-monophosphate dependent regulation of protein tyrosine phosphorylation in relation to human sperm capacitation and motility. Biol Reprod 55:684-692.
21. Levitzki A. 1990. Tyrphostins-potential antiproliferative agents and novel molecular tools. Biochem Pharamacol 40:913-918.
22. Leyton L, LeGuen P, Bunch D, Saling PM. 1992. Regulation of mouse gamete interaction by a sperm tyrosine kinase. Proc Natl Acad Sci USA 89:11692-11695.
23. Lyall RM, Zilberstein A, Gazit A, Gilon C, Levitzki A, Schlessinger J. 1989. Tyrphostins inhibit epidermal growth factor (EGF)-receptor tyrosine kinase activity in living cells and EGF-stimulated cell proliferation. J Biol Chem 264:14503-14509.
24. Mandal A, Naaby-Hansen S, Wolkowicz MJ, Klotz K, Shetty J, Retief JD, Coonrod SA, Kinter M, Sherman N, Cesar F, Flickinger CJ, Herr JC. 1999. FSP95, a testis-specific 95-kilodalton fibrous sheath antigen that undergoes tyrosine phosphorylation in capacitated human spermatozoa. Biol Reprod 61:1184-1197.
25. Mitra K, Shivaji S. 2004. Novel tyrosine-phosphorylated post-pyruvate metabolic enzyme, dihydrolipoamide dehydrogenase, involved in capacitation of hamster spermatozoa. Biol Reprod 70:887-899.
26. Mitra K, Rangaraj N, Shivaji S. 2005. Novelty of the pyruvate metabolic enzyme dihydrolipoamide dehydrogenase in spermatozoa: Correlation of its localization, tyrosine phosphorylation and activity during sperm capacitation. J Biol Chem 280:25743-25753.
27. Naaby-Hansen S, Mandal A, Wolkowicz MJ, Sen B, Westbrook VA, Shetty J, Coonrod SA, Klotz KL, Kim Y, Bush LA, Flickinger CJ, Herr JC. 2002. CABYR, a novel calcium-binding tyrosine phosphorylation-regulated fibrous sheath protein involved in capacitation. Dev Biol 242:236-254.
28. Nagdas SK, Winfrey VP, Olson GE. 2005. Tyrosine phosphorylation generates multiple isoforms of the mitochondrial capsule protein, phospholipid hydroperoxide glutathione peroxidase (PHGPx), during hamster sperm capacitation. Biol Reprod 72:164-171.
29. Nolan MA, Babcock DF, Wennemuth G, Brown W, Burton KA, McKnight GS. 2004. Sperm-specific protein kinase A catalytic subunit Cα2 orchestrates cAMP signaling for male fertility. Proc Natl Acad Sci USA 101:13483-13488.
30. Oko R. 1988. Comparitive analysis of proteins from the fibrous sheath and outer dense fibers of rat spermatozoa. Biol Reprod 39:169-182.
31. Phillips DM. 1972. Comparative analysis of mammalian sperm motility. J Cell Biol 53:561-573.
32. Pukashenthi BS, Wildt DE, Ottinger MA, Howard J. 1998. Inhibition of domestic cat spermatozoa acrosome reaction and zona pellucida penetration by tyrosine kinase inhibitors. Mol Reprod Dev 49:48-57.
33. Seshagiri PB, Thomas M, Sreekumar A, Ray PS, Mariappa D. 2003. Pentoxifylline induced signaling events during capacitation of hamster spermatozoa: Significance of protein tyrosine phosphorylation. Cell Mol Biol (Noisy-le-grand) 49:371-380.
34. Si Y, Okuno M. 1999. Role of tyrosine phosphorylation of flagellar proteins in hamster sperm hyperactivation. Biol Reprod 61:240-246.
35. Thundathil J, De Lamirande E, Gagnon C. 2002. Different signal transduction pathways are involved during human sperm capacitation induced by biological and pharmacological agents. Mol Hum Rep 8:811-816.
36. Tomes CN, Roggero CM, De Blas G, Saling PM, Mayorga LS. 2004. Requirement of protein tyrosine kinase and phosphatase activities for human sperm exocytosis. Dev Biol 265:399-415.
37. Uma Devi K, Jha K, Patil SB, Padma P, Shivaji S. 2000. Inhibition of motility of hamster spermatozoa by protein tyrosine kinase inhibitors. Andrologia 32:95-106.
38. Visconti PE, Moore GD, Bailey JL, Leclerc P, Connors SA, Pan D, Olds-Clarke P, Kopf GS. 1995. Capacitation in mouse spermatozoa. I. Correlation between the capacitation state and protein tyrosine phosphorylation. Development 121:1129-1137.
39. Visconti PE, Johnson LR, Oyaski M, Fornes M, Moss SB, Gerton GL, Kopf GS. 1997. Regulation, localization and anchoring of protein kinase A subunits during mouse sperm capacitation. Dev Biol 192: 351-363.
40. Yanagimachi R. 1994. Mammalian fertilization. In: Knobil E, Neill J, editors. Physiol reprod. New York: Raven Press, pp 189-317.
41. Yeung CH, Morrell JM, Cooper TG, Weinbauer GF, Hodges JK, Nieschlag E. 1996. Maturation of sperm motility in the epididymis of the common marmoset (Callithrix jacchus) and the cynomolgus monkey (Macaca fascicularis). Int J Androl 19:113-121.