High dose magnesium infusions are not associated with increased pressor requirements after carotid endarterectomy

Neurosurgery

Volumn 58, Issue 1, 2006, Pages 71-76

  Chiu, Camay ^a   Heyer, Eric J ^a,c   Rampersad, Anita D ^a   Zurica, Joseph ^a   Ornstein, Eugene ^a   Sahlein, Daniel H ^b   Sciacca, Robert R ^a   Connolly Jr , E Sander ^a  

^a Columbia University College of Physicians and Surgeons ^*  (United States)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c PH 5 523 ^*  (United States)

Author keywords

Carotid endarterectomy; Cerebral protection; Hypotension; Magnesium; Phenylephrine

Indexed keywords

ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; MAGNESIUM SULFATE; PHENYLEPHRINE; PLACEBO;

AGED; ARTICLE; CAROTID ARTERY OBSTRUCTION; CAROTID ENDARTERECTOMY; CLINICAL ARTICLE; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG MEGADOSE; ELECTIVE SURGERY; FEMALE; HUMAN; HYPOTENSION; INCIDENCE; MALE; PHASE 1 CLINICAL TRIAL; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; STATISTICAL SIGNIFICANCE; STROKE; SYSTOLIC BLOOD PRESSURE;

ADRENERGIC ALPHA-AGONISTS; AGED; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; ENDARTERECTOMY, CAROTID; FEMALE; HUMANS; HYPOTENSION; INCIDENCE; INFUSIONS, INTRAVENOUS; MAGNESIUM; MALE; NEUROPROTECTIVE AGENTS; PHENYLEPHRINE; POSTOPERATIVE CARE;

EID: 30144435875     PISSN: 0148396X     EISSN: None     Source Type: Journal    
DOI: 10.1227/01.NEU.0000190662.71046.66     Document Type: Article

References (18)

1. Amadeu E, Lopes E, Barbot J, Meireles A, Amorim P: Magnesium may cross the intact blood brain barrier in humans. J Neurosurg Anesthesiol 11:317, 1999.
2. Bourgeois FJ, Thiagarajah S, Harbert GM Jr, DiFazio C: Profound hypotension complicating magnesium therapy. Am J Obstet Gynecol 154:919-920, 1986.
3. Crowther CA, Hiller JE, Doyle LW, Haslam RR: Effect of magnesium sulfate given for neuroprotection before preterm birth: A randomized controlled trial. JAMA 290:2669-2676, 2003.
4. Crozier TA, Radke J, Weyland A, Sydow M, Seyde W, Markakis E, Kettler D: Haemodynamic and endocrine effects of deliberate hypotension with magnesium sulphate for cerebral-aneurysm surgery. Eur J Anaesthesiol 8:115-121, 1991.
5. Esen F, Erdem T, Aktan D, Kalayci R, Cakar N, Kaya M, Telci L: Effects of magnesium administration on brain edema and blood-brain barrier break-down after experimental traumatic brain injury in rats. J Neurosurg Anesthesiol 15:119-125, 2003.
6. Esen F, Erdem T, Aktan D, Orhan M, Kaya M, Eraksoy H, Cakar N, Telci L: Effect of magnesium sulfate administration on blood-brain barrier in a rat model of intraperitoneal sepsis: A randomized controlled experimental study. Crit Care 9:R18-R23, 2005.
7. Frohlich EP: Profound hypotension complicating magnesium therapy. Am J Obstet Gynecol 157:513, 1987.
8. Heyer EJ, Sharma R, Rampersad A, Winfree CJ, Mack WJ, Solomon RA, Todd GJ, McCormick PC, McMurtry JG, Quest DO, Stern Y, Lazar RM, Connolly ES Jr: A controlled prospective study of neuropsychological dysfunction following carotid endarterectomy. Arch Neurol 59:217-222, 2002.
9. McCombs J: Treatment of preeclampsia and eclampsia. Clin Pharm 11:236-245, 1992.
10. McKee JA, Brewer RP, Macy GE, Phillips-Bute B, Campbell KA, Borel CO, Reynolds JD, Warner DS: Analysis of the brain bioavailability of peripherally administered magnesium sulfate: A study in humans with acute brain injury undergoing prolonged induced hypermagnesemia. Crit Care Med 33:661-666, 2005.
11. McKevitt FM, Sivaguru A, Venables GS, Cleveland TJ, Gaines PA, Beard JD, Charmer KS: Effect of treatment of carotid artery stenosis on blood pressure: A comparison of hemodynamic disturbances after carotid endarterectomy and endovascular treatment. Stroke 34:2576-2581, 2003.
12. Mittendorf R, Pryde PG: A review of the role for magnesium sulphate in preterm labour. BJOG 112[Suppl 1]:84-88, 2005.
13. Muir KW: Magnesium in stroke treatment. Postgrad Med J 78:641-645, 2002.
14. Muir KW, Lees KR, Ford I, Davis S: Magnesium for acute stroke (Intravenous Magnesium Efficacy in Stroke trial): Randomised controlled trial. Lancet 363:439-445, 2004.
15. Ransom BR, Stys PK, Waxman SG: The pathophysiology of anoxic injury in central nervous system white matter. Stroke 21[Suppl 11]:III52-57, 1990.
16. Vanninen E, Vanninen R, Aikia M, Tulla H, Kononen M, Koivisto K, Partanen J, Partanen K, Hippelainen M, Kuikka JT: Frequency of carotid endarterectomy-related subclinical cerebral complications. Cerebrovascular Diseases 6:272-280, 1996.
17. Zausinger S, Scholler K, Plesnila N, Schmid-Elsaesser R: Combination, drug therapy and mild hypothermia after transient focal cerebral ischemia in rats. Stroke 34:2246-2251, 2003.
18. Zausinger S, Westermaier T, Plesnila N, Steiger HJ, Schmid-Elsaesser R: Neuroprotection in transient focal cerebral ischemia by combination drug therapy and mild hypothermia: Comparison with customary therapeutic regimen. Stroke 34:1526-1532, 2003.