MEL1S, not MEL1, is overexpressed in myelodysplastic syndromes patients with t(1;3)(p36;q21)

Leukemia Research

Volumn 30, Issue 3, 2006, Pages 332-334

  Xiao, Zhijian ^a   Zhang, Meirong ^a   Liu, Xuping ^a   Zhang, Yue ^a   Yang, Lin ^a   Hao, Yushu ^a  

^a INSTITUTE OF HEMATOLOGY AND BLOOD DISEASES HOSPITAL   (China)

Author keywords

MEL1; MEL1S; Myelodysplastic syndromes; t(1 ; 3)(p36 ; q21)

Indexed keywords

ARTICLE; BONE MARROW; CHINESE; CHROMOSOME ANALYSIS; CHROMOSOME TRANSLOCATION; GENE EXPRESSION; GENE OVEREXPRESSION; HUMAN; KARYOTYPING; LABORATORY TEST; MEL 1 GENE; MEL1S GENE; MYELODYSPLASTIC SYNDROME; ONCOGENE; PRIORITY JOURNAL;

AGED; CHROMOSOMES, HUMAN, PAIR 1; CHROMOSOMES, HUMAN, PAIR 3; DNA-BINDING PROTEINS; FEMALE; GENE EXPRESSION REGULATION; HUMANS; MALE; MIDDLE AGED; MYELODYSPLASTIC SYNDROMES; PROTEIN STRUCTURE, TERTIARY; RNA, MESSENGER; SEQUENCE DELETION; TRANSCRIPTION FACTORS; TRANSLOCATION, GENETIC;

EID: 30144431840     PISSN: 01452126     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.leukres.2005.07.002     Document Type: Article

References (5)

1. D.J. Moir, P.A.E. Jones, and J.J. Pearson A new translocation, t(1;3)(p36;q21), in myelodysplastic disorders Blood 64 1984 553 555
2. S. Shimizu, K. Suzukawa, and T. Kodera Identification of breakpoint cluster regions at 1p36.3 and 3q21 in hematologic malignancies with t(1;3)(p36;q21) Genes Chromosomes Cancer 27 2000 229 238
3. N. Mochizuki, S. Shimizu, and T. Nagasawa A novel gene, MEL1, mapped to 1p36.3 is highly homologous to the MDS1/EVI1 gene and is transcriptionally activated in t(1;3)(p36;q21)-positive leukemia cells Blood 96 2000 3209 3214
4. I. Nishikata, H. Sasaki, and M. Iga A novel EVI1 gene family, MEL1, lacking a PR domain (MEL1S) is expressed mainly in t(1;3)(p36;q21)-positive AML and blocks G-CSF-induced myeloid differentiation Blood 102 2003 3323 3332
5. I. Lahortiga, X. Agirre, and E. Belloni Molecular characterization of a t(1;3)(p36;q21) in a patient with MDS. MEL1 is widely expressed in normal tissues, including bone marrow, and it is not overexpressed in the t(1;3) cells Oncogene 23 2004 311 316