p53 tumor suppressor protein regulates the levels of huntingtin gene expression

Oncogene

Volumn 25, Issue 1, 2006, Pages 1-7

  Feng, Z ^a   Jin, S ^a,b   Zupnick, A ^c   Hoh, J ^d   De Stanchina, E ^e   Lowe, S ^e   Prives, C ^c   Levine, A J ^a,f  

^a RUTGERS CANCER INSTITUTE OF NEW JERSEY   (United States)

^b UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY   (United States)

^c Och Spine at New York Presbyterian Hospitals   (United States)

^d YALE UNIVERSITY   (United States)

^e Howard Hughes Medical Institute Cold Spring Harbor Laboratory Cold Spring Harbor   (United States)

^f INSTITUTE FOR ADVANCED STUDY   (United States)

Author keywords

Gene expression; Hungtingtin; Huntington's disease; p53; p53 responsive element; Transcription regulation

Indexed keywords

HUNTINGTIN; MESSENGER RNA; PROTEIN P53; TUMOR SUPPRESSOR PROTEIN;

ANIMAL EXPERIMENT; ARTICLE; BRAIN CORTEX; CELL CULTURE; CONTROLLED STUDY; CORPUS STRIATUM; FEMALE; GAMMA IRRADIATION; GENE EXPRESSION; HUMAN; HUMAN CELL; HUNTINGTON CHOREA; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; TEMPERATURE SENSITIVITY; TRANSCRIPTION REGULATION;

ANIMALS; BLOTTING, NORTHERN; BLOTTING, WESTERN; CELL LINE, TUMOR; CHROMATIN IMMUNOPRECIPITATION; DNA DAMAGE; GAMMA RAYS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; HUNTINGTON DISEASE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; MUTATION; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; RESPONSE ELEMENTS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; TEMPERATURE; TIME FACTORS; TRANSCRIPTION, GENETIC; TUMOR SUPPRESSOR PROTEIN P53;

ANIMALIA; MURINAE;

EID: 30044438329     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/sj.onc.1209021     Document Type: Article

References (20)

1. Anca MH, Gazit E, Loewenthal R, Ostrovsky O, Frydman M, Giladi N. (2004). Am J Med Genet A 124: 89-91.
2. Bunz F, Dutriaux A, Lengauer C, Waldman T, Zhou S, Brown JP et al. (1998). Science 282: 1497-1501.
3. DiFiglia M, Sapp E, Chase KO, Davies SW, Bates GP, Vonsattel JP et al. (1997). Science 277: 1990-1993.
4. Dixon KT, Cearley JA, Hunter JM, Detloff PJ. (2004). Gene Expr 11: 221-231.
5. el-Deiry WS, Kern SE, Pietenpol JA, Kinzler KW, Vogelstein B. (1992). Nat Genet 1: 45-49.
6. Georgiou N, Bradshaw JL, Chiu E, Tudor A, O'Gorman L, Phillips JG. (1999). Mov Disord 14: 320-325.
7. Hoh J, Jin S, Parrado T, Edington J, Levine AJ, Ott J. (2002). Proc Natl Acad Sci USA 99: 8467-8472.
8. Huntington's Disease Collaborative Research Group (1993). Cell 72: 971-983.
9. Jin S, Levine AJ. (2001). J Cell Sci 114: 4139-4140.
10. Jin Y, Zeng SX, Dai MS, Yang XJ, Lu H. (2002). J Biol Chem 277: 30838-30843.
11. Levine AJ. (1997). Cell 88: 323-331.
12. Li SH, Li XJ. (2004). Trends Genet 20: 146-154.
13. Lowe SW, Schmitt EM, Smith SW, Osborne BA, Jacks T. (1993). Nature 362: 847-849.
14. Nasir J, Floresco SB, O'Kusky JR, Diewert VM, Richman JM, Zeisler J et al. (1995). Cell 81: 811-823.
15. Pochampally R, Fodera B, Chen L, Lu W, Chen J. (1999). J Biol Chem 274: 15271-15277.
16. Sharp AH, Ross CA. (1996). Neurobiol Dis 3: 3-15.
17. Steffan JS, Kazantsev A, Spasic-Boskovic O, Greenwald M, Zhu YZ, Gohler H et al. (2000). Proc Natl Acad Sci USA 97: 6763-6768.
18. Trushina E, Dyer RB, Badger II JD, Ure D, Eide L, Tran DD et al. (2004). Mol Cell Biol 24: 8195-8209.
19. Vogelstein B, Lane D, Levine AJ. (2000). Nature 408: 307-310.
20. Wu X, Levine AJ. (1994). Proc Natl Acad Sci USA 91: 3602-3606.