TP53, Bcl-2 and growth hormone receptor expression in cutaneous squamous cell carcinoma

Acta Dermatovenerologica Croatica

Volumn 13, Issue 4, 2005, Pages 201-205

  Stanimirović, Andrija ^a   Čupić, Hrvoje ^a   Bošnjak, Berislav ^b   Tomas, Davor ^a   Krušlin, Božo ^a   Belicza, Mladen ^a  

^a SESTRE MILOSRDNICE UNIVERSITY HOSPITAL   (Croatia)

^b PLIVA Research Institute Ltd   (Croatia)

Author keywords

Bcl 2; Growth hormone receptor; Immunohistochemistry; Squamous cell carcinoma; TP53

Indexed keywords

GROWTH HORMONE RECEPTOR; PROTEIN BCL 2; PROTEIN P53;

ADULT; ARTICLE; CELL PROLIFERATION; CORRELATION ANALYSIS; FEMALE; GENE MUTATION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MAJOR CLINICAL STUDY; MALE; PRECANCER; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTO ONCOGENE; QUANTITATIVE ANALYSIS; SKIN CARCINOGENESIS; SKIN CARCINOMA; SQUAMOUS CELL CARCINOMA;

CARCINOMA, SQUAMOUS CELL; CARRIER PROTEINS; FEMALE; HUMANS; MALE; MIDDLE AGED; PROTO-ONCOGENE PROTEINS C-BCL-2; SKIN NEOPLASMS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 29944443430     PISSN: 1330027X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Salasche SJ. Epidemiology of actinic keratosis and squamous cell carcinoma. J Am Acad Dermatol 2000;42:S4-7.
2. Mittelbronn MA, Mullins DL, Ramos-Caro FA, Flowers FP. Frequency of pre-exisiting actinic keratoses in cutaneous squamous cell carcinoma. Int J Dermatol 1998;37:677-81.
3. Lober BA, Lober CW. Actinic keratosis is squamous cell carcinoma. South Med J 2000;93:650-5.
4. Cockerell CJ. Histopathology of incipient intraepidermal squamous cell carcinoma ("actinic keratosis"). J Am Acad Dermatol 2000;42:S11-7.
5. Tucci MG, Offidani A, Lucarini G, Simonelli L, Amati S, Cellini A, et al. Advances in the understanding of malignant transformation of keratinocytes: an immunohistochemical study. J Eur Acad Dermatol Venereol 1998;10:118-24.
6. Wikonkal NM, Berg RJ, van Haselen CW, Horkay I, Remenyik E, Begany A, et al. Bcl-2 vs p53 protein expression and apoptotic rate in human nonmelanoma skin cancers. Arch Dermatol 1997;133:599-602.
7. Ziegler A, Leffell DJ, Kunala S, Sharma HW, Gailani M, Simon JA, et al. Sunburn and p53 in the onset of skin cancer. Nature 1994;372: 773-6.
8. Gusterson BA, Anbazhagan R, Warren W, Midgely C, Lane DP, O'Hare M, et al. Expression of p53 in premalignant and malignant squamous epithelium. Oncogene 1991;6: 1785-9.
9. Nelson MA, Einspahr JG, Alberts DS, Balfour CA, Wymer JA, Welch KL, et al. Analysis of the p53 gene in human precancerous actinic keratosis lesions and squamous cell cancers. Cancer Lett 1994;85:23-9.
10. Nagano T, Ueda M, Ichihashi M. Expression of p53 protein is an early event in ultraviolet light-induced cutaneous squamous cell carcinogenesis. Arch Dermatol 1993;129:1157-61.
11. Onodera H, Nakamura S-I, Sugai T. Cell proliferation and p53 protein expression in cutaneous epithelial neoplasms. Am J Dermatopathol 1996;18:580-8.
12. Bito T, Ueda M, Ahmed NU, Nagano T, Ichihashi M. Cyclin D and retinoblastoma gene product expression in actinic keratosis and cutaneous squamous cell carcinoma in relation to p53 expression. J Cutan Pathol 1995;22:427-34.
13. McGregor JM, Yu CCW, Dublin EA, Levison DA, MacDonald DM. Aberrant expression of p53 tumour-suppressor protein in non-melanoma skin cancer. Br J Dermatol 1992;127:463-9.
14. Stephenson TJ, Royds J, Silcoks PB, Bleehen SS. Mutant p53 oncogene expression in keratoacanthoma and squamous cell carcinoma. Br J Dermatol 1992;127:566-70.
15. Nakagawa K, Yamamura K, Maeda S, Ichihasi M. Bcl-2 expression in epidermal keratinocytic diseases. Cancer 1994;74:1720-4.
16. Wrone-Smith T, Bergstrom J, Quevedo ME, Reddy V, Gutierrez-Steil C, Nickoloff BJ. Differential expression of cell survival and cell cycle regulatory proteins in cutaneous squamoproliferative lesions. J Dermatol Sci 1999;19:53-67.
17. Delehedde M, Cho SH, Sarkiss M, Brisbay S, Davies M, El-Naggar AK, et al. Altered expression of bcl-2 family member proteins in nonmelanoma skin cancer. Cancer 1999;85: 1514-22.
18. Morales-Ducret CR, van de Rijn M, LeBrun DP, Smoller BR. Bcl-2 expression in primary malignancies of the skin. Arch Dermatol 1995;131:909-12.
19. Lincoln DT, Sinowatz F, Temmim-Baker L, Baker HI, Kölle S, Waters MJ. Growth hormone receptor expression in the nucleus and cytoplasm of normal and neoplastic cells. Histochem Cell Biol 1998;109:141-59.
20. Ginarte M, Garcia-Cabarello T, Fernández-Redondo V, Beiras A, Toribio J. Expression of growth hormone receptor in benign and malignant cutaneous proliferative entities. J Cutan Pathol 2000;27:276-82.
21. Stanimirović A, Čupić H, Bošnjak B, Krušlin B, Belicza M. Expression of p53, bcl-2 and growth hormone receptor in actinic keratosis, hypertrophic type. Arch Dermatol Res 2003;295: 102-8.
22. Stanimirović A, Čupić H, Bošnjak B, Tomas D, Baličević D, Krušlin B, et al. Expression of p53, bcl-2 and growth hormone receptor in atrophic type of actinic keratosis. J Dermatol Sci 2004;34:49-53.
23. Rossiter H, Beissert S, Mayer C, Schon MP, Wienrich BG, Tschachler E, et al. Targeted expression of bcl-2 to murine basal epidermal keratinocytes results in paradoxical retardation of ultraviolet- and chemical-induced tumorigenesis. Cancer Res 2001;61:3619-29.
24. Miyashita T, Reed JC. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 1995;80:293-9.
25. Chao DT, Korsmeyer SJ. BCL-2 family: regulators of cell death. Annu Rev Immunol 1998;16:395-419.