Expression of p53, bcl-2 and growth hormone receptor in actinic keratosis, hypertrophic type

Archives of Dermatological Research

Volumn 295, Issue 3, 2003, Pages 102-108

  Stanimirović, Andrija ^a,c   Čupić, Hrvoje ^a   Bošnjak, Berislav ^b   Krušlin, Božo ^a   Belicza, Mladen ^a  

^a SESTRE MILOSRDNICE UNIVERSITY HOSPITAL   (Croatia)

^b RUDER BO KOVI INSTITUTE   (Croatia)

^c NONE   (Croatia)

Author keywords

Bcl 2; Growth hormone receptor; Hypertrophic actinic keratosis; Immunohistochemistry; P53

Indexed keywords

BIOLOGICAL MARKER; GROWTH HORMONE RECEPTOR; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53;

ACTINIC KERATOSIS; APOPTOSIS; ARTICLE; CANCER INVASION; GENE MUTATION; HUMAN; HUMAN TISSUE; HYPERTROPHIC SKIN DISEASE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTO ONCOGENE; SQUAMOUS CELL CARCINOMA; TUMOR SUPPRESSOR GENE;

FEMALE; HUMANS; HYPERTROPHY; KERATOSIS; MALE; MIDDLE AGED; PROTO-ONCOGENE PROTEINS C-BCL-2; RECEPTORS, SOMATOTROPIN; SKIN; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0043160515     PISSN: 03403696     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00403-003-0400-0     Document Type: Article

References (41)

1. Argentsinger LS, Campbell GS, Yang X (1993) Identification of JAK2 as a growth hormone receptor associated kinase. Cell 74:237-244
2. Bito T, Ueda M, Ahmed NU, Nagano T, Ichihashi M (1995) Cyclin D and retinoblastoma gene product expression in actinic keratosis and cutaneous squamous cell carcinoma in relation to p53 expression. J Cutan Pathol 22:427-434
3. Campbell C, Quinn AG, Angus B, Farr PM, Rees JL (1993a) Wavelength specific patterns of p53 induction in human skin following exposure to UV irradiation. Cancer Res 53:2697-2699
4. Campbell C, Quinn AG, Angus B, Rees JL (1993b) The relation between p53 mutation and p53 immunostaining in non-melanoma skin cancer. Br J Dermatol 129:235-241
5. Chao DT, Korsmeyer SJ (1998) BCL-2 family: regulators of cell death. Annu Rev Immunol 16:395-419
6. Elder D, Elenitsas R, Jaworsky C, Johnson B Jr (1997) Lever's histopathology of the skin, 8th edn. Lippincott-Raven, Philadelphia, pp 701-740
7. Engman MF (1915) Precancerous conditions of the skin. J Lab Clin Med 1:31-39
8. Farrell PJ, Allan GJ, Shanahan F, Vousden KH, Crook T (1991) p53 is frequently mutated in Burkitt's lymphoma cell lines. EMBO J 88:5413-5417
9. Gilchrest BA, Krassik RL, Wilkins LM, Vrabel MA, Macaig T (1983) Autocrine and paracrine growth stimulation of cells derived from human skin. J Cell Physiol 117:235-240
10. Ginarte M, García-Cabarello T, Fernández-Redondo V, Beiras A, Toribio J (2000) Expression of growth hormone receptor in benign and malignant cutaneous proliferative entities. J Cutan Pathol 27:276-282
11. Green A, Beardmore G, Hart V, Leslie D, Marks R, Staines D (1988) Skin cancer in a Queensland population. J Am Acad Dermatol 19:1045-1052
12. Gusterson BA, Anbazhagan R, Warren W, Midgely C, Lane DP, O'Hare M, et al (1991) Expression of p53 in premalignant and malignant squamous epithelium. Oncogene 6:1785-1789
13. Hall PA, McKee PH, Menage HP, Dover R, Lane DP (1993) High levels of p53 protein in UV-irradiated normal human skin. Oncogene 8:203-207
14. Jenkins JR, Rudge K, Chumakov P, Currie GA (1985) The cellular oncogene p53 can be activated by mutagenesis. Nature 317:816-818
15. Klein G, Klein E (1985) Evolution of tumours and the impact of molecular oncology. Nature 359:190-195
16. Kwa RE, Campana K, Moy RL (1992) Biology of cutaneous squamous cell carcinoma. J Am Acad Dermatol 26:1-26
17. Leffell DJ (2000) The scientific basis of skin cancer. J Am Acad Dermatol 42:S18-S22
18. Lincoln DT, Sinowatz F, Temmim-Baker L, Baker HI, Kölle S, Waters MJ (1998) Growth hormone receptor expression in the nucleus and cytoplasm of normal and neoplastic cells. Histochem Cell Biol 109:141-159
19. Lobie PE, Breipohl W, Lincoln DT, García-Aragón J, Waters MJ (1990) Localization of growth hormone receptor/binding protein in skin. J Endocrinol 126:467-472
20. Mills AE (1997) Solar keratosis can be distinguished from superficial basal cell carcinoma by expression of bcl-2. Am J Dermatopathol 19:443-445
21. Miyashita T, Reed JC (1995) Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 80:293-299
22. Momand J, Zambetti GP, Olson DC, George DL, Levine AJ (1992) The MDM2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell 69:1237-1245
23. Morales-Ducret CR, van de Rijn M, LeBrun DP, Smoller BR (1995) bcl-2 expression in primary malignancies of the skin. Arch Dermatol 131:909-912
24. Moy RL (2000) Clinical presentation of actinic keratoses and squamous cell carcinoma. J Am Acad Dermatol 42:S8-S10
25. Nagano T, Ueda M, Ichihashi M (1993) Expression of p53 protein is an early event in ultraviolet light-induced cutaneous squamous cell carcinogenesis. Arch Dermatol 129:1157-1161
26. Nakagawa K, Yamamura K, Maeda S, Ichihashi M (1994) bcl-2 expression in epidermal keratinocytic diseases. Cancer 74:1720-1724
27. Oakes SR, Haynes KM, Waters MJ, Herington AC, Werther GA (1992) Demonstration and localization of growth hormone receptor in human skin and skin fibroblasts. J Clin Endocrinol Metab 75:1368-1373
28. Oltvai ZN, Milliman CL, Korsmeyer SJ (1993) Bcl-2 heterodimers in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 74:609-619
29. Onodera H, Nakamura S, Sugai T (1996) Cell proliferation and p53 protein expression in cutaneous epithelial neoplasms. Am J Dermatopathol 18:580-588
30. Pinkus H (1979) Epithelial neoplasms and precancerous lesions. In: Fitzpatrick TB, et al (eds) Dermatology in general medicine. McGraw-Hill, New York, pp 354-361
31. Prunieri G, Pignataro L, Carboni N, Luminari S, Cappaccio P, Neri A, Buffa R (1997) MDM-2 oncoprotein overexpression in laryngeal squamous cell carcinoma: association with wild-type p53 accumulation. Mod Pathol 10:785-792
32. Radfar A, Unnikrishnan I, Lee HW, DePinho RA, Rosenberg N (1998) p19(Arf) induces p53-dependent apoptosis during Abelson virus-mediated pre-B cell transformation. Proc Natl Acad Sci U S A 95:13194-13199
33. Reich NC, Oren M. Levine AJ (1983) Two distinct mechanisms regulate the levels of a cellular tumor antigen, p53. Mol Cell Biol 3:2143-2150
34. Rosembloom AL, Guevara-Aguirre J, Fielder PJ, et al (1993) Laron syndrome (growth hormone receptor deficiency) in Ecuador: clinical and biochemical characteristics. In: Laron Z, Parks JS (eds) Lessons from Laron syndrome (LS) 1966-1992. Pediatric and adolescent endocrinology. Karger, Basel, pp 24-34
35. Salasche SJ (2000) Epidemiology of actinic keratoses and squamous cell carcinoma. J Am Acad Dermatol 42:S4-S7
36. Shimizu T, Oga A, Murakami T, Muto M (1999) Overexpression of P53 protein associated with proliferative activity and histological degree of malignancy in solar keratosis. Dermatology 199:113-118
37. Stanimirović A, Čupić H, Krušlin B, Belicza M, Ginarte M (2001) Expression of growth hormone receptor in squamous cell carcinoma of the skin. J Eur Acad Dermatol Venereol 15 [Suppl 2]: 162
38. Taguchi M, Watanabe S, Sato Y, Kameya T, Munakata N, Ishihara K, et al (1993) Immunohistochemical examination of tumor-suppressor gene p53 product and pyrimidine dimer in solar keratosis. J Cancer Res Clin Oncol 119:260-262
39. Tindall JP (1976) Skin changes and lesions in our senior citizens: incidences. Cutis 18:359-362
40. Tucci MG, Offidani A, Lucarini G, Simonelli L, Amati S, Cellini A, et al (1998) Advances in the understanding of malignant transformation of keratinocytes: an immunohistochemical study. J Eur Acad Dermatol Venereol 10:118-124
41. Wikonkal NM, Berg RJ, van Haselen CW, Horkay I, Remenyik E, Begany A, et al (1997) bcl-2 vs. p53 expression and apoptotic rate in human nonmelanoma skin cancers. Arch Dermatol 133:599-602