Analysis of a kanamycin resistance gene (kmr) from Streptomyces kanamyceticus and a mutant with increased aminoglycoside resistance

Journal of Basic Microbiology

Volumn 38, Issue 4, 1998, Pages 231-239

  Demydchuk, Julia ^a   Oliynyk, Zoryana ^a   Fedorenko, Victor ^a  

^a IVAN FRANKO NATIONAL UNIVERSITY OF LVIV   (Ukraine)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOGLYCOSIDE; ANTIBIOTIC RESISTANCE; GENE SEQUENCING; GENTAMICIN; KANAMYCIN; SISOMICIN; TOBRAMYCIN;

AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BASE SEQUENCE; BLOTTING, SOUTHERN; CLONING, MOLECULAR; DRUG RESISTANCE, MICROBIAL; GENES, RRNA; KANAMYCIN; KANAMYCIN RESISTANCE; MOLECULAR SEQUENCE DATA; PLASMIDS; RESTRICTION MAPPING; RNA, RIBOSOMAL, 16S; SEQUENCE ANALYSIS, DNA; STREPTOMYCES; TRNA METHYLTRANSFERASES;

EID: 0031705699     PISSN: 0233111X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-4028(199809)38:4<231::AID-JOBM231>3.0.CO;2-W     Document Type: Article

References (22)

1. BEAUCLERK, A. A. D. and CUNDLIFFE, E., 1987. Sites of two ribosomal RNA methylases responsible for resistance to aminoglycosides. J. Mol. Biol., 193, 661-671.
2. BIBB, M. J. and COHEN, S. N., 1982. Gene expression in Streptomyces: construction and application of promoter-probe plasmid vectors in Streptomyces lividans. Mol. Gen.Genet., 187, 265-277.
3. BIBB, M. J., FINDLAY, P. R. and JOHNSON, M. W., 1984. The relationship between base composition and codon usage in bacterial genes and its use for the simple and reliable identification of protein-coding sequences. Gene, 30, 157-66.
4. CUNDLIFFE, E., 1989. How antibiotic-producing organisms avoid suicide. Annu. Rev. Microbiol., 43, 207-233.
5. DEMYDCHUK, J. A., GOLETS, L. M. and FEDORENKO, V. A., 1996. Characteristics of Streptomyces kanamyceticus mutants resistant to aminoglycoside antibiotics. Antibiot. and Chemioterap., 41, 15-20.
6. DEMYDCHUK, J., 1998. Genetic mechanisms of the resistance of Streptomyces kanamyceticus to amynoglicosides. PhD thesis, in press.
7. FEDORENKO, V. A., GOLETS, L. M. and DEMYDCHUK, J. A., 1998. Analysis of the genomic rearrangements of Streptomyces kanamyceticus strains. Antibiot. and Chemioterap., 43, 14-19.
8. HOLMS, D. and CUNDLIFFE, E., 1991 a. Analysis of a ribosomal RNA methylase gene from Streptomyces tenebrarius which confers resistance to gentamicin. Mol. General.Genetics, 229, 229-237.
9. HOLMS, D., DROCOURT, D. and TIRABY, G., 1991 b. Cloning of an aminoglycoside-resistance-encoding gene, kamC, from Saccharopolyspora hirsuta: comparison with kamB from Streptomyces tenebrarius. Gene, 102, 19-26.
10. HOPWOOD, D. A., BIBB, M. J., CHATER, K. F. and KIESER, T., 1985. Gene Manipulation of Streptomyces, a Laboratory Manual. The John Innes Foundation, Norwich, U.K.
11. KELEMEN, G. H., CUNDLIFFE, E. and FINANCSEK, I., 1991. Cloning and characterization of gentamicin-resistance genes from Micromonospora purpurea and Micromonospora rosea. Gene, 98, 53-60.
12. KOJIC, M., TOPISIROVIC, L. and VASILJEVIC, B., 1992. Cloning and characterization of an aminoglycoside resistance determinant from Micromonospora zionensis. J. Bacteriol., 174, 7868-7872.
13. MARTIN, J. F. and DEMAIN, A. L., 1980. Control of antibiotic biosynthesis. Microbiol. Rev., 44, 230-251.
14. MASAROU, M. and TOSHIO, N., 1978. Interaction of kanamycin and related antibiotics with the large subunit of ribosomes and the inhibition of translocation. Biochem. and Biophys. Res. Commun., 84, 358-365.
15. MURAKAMI, T., NOJIRI, C. and TOYAMA, H., 1983. Cloning of antibiotic-resistance genes in Streptomyces. J. Antibiot., 36, 1305-1311.
16. NAKANO, M., BUTSUYA, I. and OGAWARA, H., 1989. Expression of the kanamycin resistance gene in a kanamycin-producing strain of Streptomyces kanamyceticus. J. Antibiot., 152, 423-430.
17. NAKANO, M. and KIKUCHI, T., 1989. Analysis of the promoter region from Streptomyces kanamyceticus. J. Antibiot., 152, 413-422.
18. NAKANO, M., MASHIKO, H. and OGAWARA, H., 1984. Cloning of the kanamycin resistance gene from a kanamycin-producing Streptomyces species. J. Bacteriol., 157, 79-83.
19. OHTA, T., DAIRI, T. and HASEGAWA, M., 1993. Characterization of two different types of resistance genes among producers of fortimicin-group antibiotics. J. Gen. Microb., 139, 591-599.
20. SAMBROOK, J. and FRITSCH, E. F., 1989. Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory Press New York.
21. SANGER, F., MCCLEN, S. and CARLSON, A. R., 1977. DNA sequencing with chain-terminating inhibitors. Proc. Nat. Acad. Sci. USA, 74, 5463-5467.
22. SKEGGS, P. A., THOMPSON, J. and CUNDLIFFE, E., 1985. Methylation of 16S ribosomal RNA and resistance to aminoglycoside antibiotics in clones of Streptomyces lividans carrying DNA from Streptomyces tenjimariensis. Mol. Gen. Genet., 204, 415-421.