High incidence of INR alteration in gastrointestinal cancer patients treated with mini-dose warfarin and 5-fluorouracil-based regimens [2]

Annals of Oncology

Volumn 17, Issue 1, 2006, Pages 174-176

  Magagnoli, Massimo ^a   Masci, G ^a   Castagna, L ^a   Morenghi, E ^a   Santoro, A ^a  

^a HUMANITAS CLINICAL AND RESEARCH CENTER   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

FLUOROURACIL; FOLINIC ACID; OXALIPLATIN; WARFARIN;

BLEEDING; BLOOD CLOTTING; BLOOD CLOTTING DISORDER; CANCER CHEMOTHERAPY; CENTRAL VENOUS CATHETERIZATION; CLINICAL TRIAL; CONTINUOUS INFUSION; DIGESTIVE SYSTEM CANCER; DRUG ABSORPTION; DRUG DOSE REGIMEN; DRUG SAFETY; HUMAN; INCIDENCE; INTERNATIONAL NORMALIZED RATIO; LETTER; PRIORITY JOURNAL; PROPHYLAXIS; PROSPECTIVE STUDY; PROTHROMBIN TIME; REFERENCE VALUE; RETROSPECTIVE STUDY; THROMBOEMBOLISM; THROMBOSIS;

ADULT; AGED; ANTICOAGULANTS; ANTIMETABOLITES, ANTINEOPLASTIC; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CATHETERIZATION, CENTRAL VENOUS; FLUOROURACIL; GASTROINTESTINAL NEOPLASMS; HUMANS; INTERNATIONAL NORMALIZED RATIO; MIDDLE AGED; PROSPECTIVE STUDIES; THROMBOSIS; WARFARIN;

EID: 29844454065     PISSN: 09237534     EISSN: 15698041     Source Type: Journal    
DOI: 10.1093/annonc/mdj002     Document Type: Letter

References (7)

1. Bern MM, Lokich JJ, Wallach SR et al. Very low doses of warfarin can prevent thrombosis in central venous catheters. Ann Intern Med 1990; 112: 423-428.
2. Boraks P, Seale J, Price J et al. Prevention of central venous catheter associated thrombosis using minidose warfarin in patients with haematological malignancies. Br J Haematol 1998; 101: 483-486.
3. Couban S, Goodyear M, Burnell M et al. Randomized placebo-controlled study of low-dose warfarin for the prevention of CVC-associated thrombosis in patients with cancer. J Clin Oncol 2005; 23: 4063-4069.
4. Heaton DC, Han DY, Inder A. Minidose (1 mg) warfarin as prophylaxis for central vein catheter thrombosis. Intern Med J 2002; 32: 84-88.
5. Masci G, Magagnoli M, Zucali PA et al. Minidose warfarin prophylaxis for catheter-associated thrombosis in cancer patients. Can it be safely associated with 5-fluorouracil-based chemotherapy? J Clin Oncol 2003; 21: 736-739.
6. Afsar A, Lee C, Riddick DS. Modulation of the expression on constitutive rat epatic cytocrome p450 isozymes by 5-fluorouracil. Can J Physiol Pharmacol 1996; 74: 150-156.
7. Magagnoli M, Masci G, Carnaghi C et al. Minidose warfarin is associated with high incidence of International Normalized Ratio elevation during chemotherapy with FOLFOX regimen. Ann Oncol 2003; 14: 959-960.