Minidose warfarin is associated with a high incidence of International Normalized Ratio elevation during chemotherapy with FOLFOX regimen [1]

Annals of Oncology

Volumn 14, Issue 6, 2003, Pages 959-960

  Magagnoli, Massimo ^a   Masci, G ^a   Carnaghi, C ^a   Zucali, P A ^a   Castagna, L ^a   Morenghi, E ^a   Santoro, A ^a  

^a HUMANITAS CLINICAL AND RESEARCH CENTER   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICOAGULANT AGENT; ANTITHROMBOCYTIC AGENT; FLUOROURACIL; FOLINIC ACID; HEPARIN; OXALIPLATIN; PROTHROMBIN; WARFARIN;

BLEEDING; CLINICAL ARTICLE; CLINICAL TRIAL; COLORECTAL CANCER; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG DOSE REGIMEN; DRUG INFUSION; DRUG WITHDRAWAL; EPISTAXIS; HEMATURIA; HUMAN; INTERNATIONAL STANDARD UNIT; LETTER; LOW DRUG DOSE; PRIORITY JOURNAL; PROTHROMBIN TIME; THROMBOCYTE DISORDER; VEIN THROMBOSIS;

ADULT; AGED; ANTICOAGULANTS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; COLONIC NEOPLASMS; DRUG THERAPY, COMBINATION; FEMALE; FLUOROURACIL; HUMANS; INCIDENCE; INTERNATIONAL NORMALIZED RATIO; LEUCOVORIN; LIVER NEOPLASMS; MALE; MIDDLE AGED; ORGANOPLATINUM COMPOUNDS; PROTHROMBIN TIME; RECTAL NEOPLASMS; WARFARIN;

EID: 0038349649     PISSN: 09237534     EISSN: None     Source Type: Journal    
DOI: 10.1093/annonc/mdg238     Document Type: Letter

References (8)

1. De Gramont A, Figer A, Seymour M et al. Leucovorin and fluorouracil with or without oxaliplatin as first line treatment in advanced colorectal cancer. J Clin Oncol 2000; 18: 2938-2947.
2. Giacchetti S, Perpoint B, Zidani R et al. Phase III multicenter randomized trial of oxaliplatin added to chronomodulated fluorouracil-leucovorin as first-line treatment of metastatic colorectal cancer. J Clin Oncol 2000; 18: 136-147.
3. Eastrige BJ, Lefor TA. Complications of indwelling venous catheter devices in cancer patients. J Clin Oncol 1995; 13: 233-238.
4. Bern MM, Lokich JJ, Wallach SR et al. Very low doses of warfarin can prevent thrombosis in central venous catheters. A randomized prospective trial. Ann Intern Med 1990; 112: 423-428.
5. Ratcliffe M, Broadfoot C, Davidson M et al. Thrombosis, markers of thrombotic risk, indwelling central venous catheters and efficiency of antithrombotic prophylaxis using low-dose of warfarin. Br J Haematol 1998; 101: 79-85.
6. Brown MC. An adverse interaction between warfarin and 5-fluorouracil: a case report and review of the literature. Chemotherapy 1999; 45: 392-395.
7. Kolesar JM, Johnson CL, Freeberg BL et al. Warfarin-5-FU interaction - a consecutive case series. Pharmacotherapy 1999; 19: 1445-1449.
8. Masci G, Magagnoli M, Zucali PA et al. Minidose warfarin prophylaxis for catheter-associated thrombosis in cancer patients: can it be safely associated with fluorouracil-based chemotherapy? J Clin Oncol 2003: 21: 736-739.