Genomic sequence analysis and organization of BmKαTx11 and BmKαTx15 from Buthus martensii Karsch: Molecular evolution of α-toxin genes

Journal of Biochemistry and Molecular Biology

Volumn 38, Issue 4, 2005, Pages 386-390

  Xu, XiuLing ^a   Cao, ZhiJian ^a   Sheng, JiQun ^a   Wu, WenLan ^a   Luo, Feng ^a   Sha, YongGang ^a   Mao, Xin ^a   Liu, Hui ^a   Jiang, DaHe ^a   Li, WenXin ^a  

^a WUHAN UNIVERSITY   (China)

Author keywords

Evolution; Intron; Organization structure; Scorpion toxin

Indexed keywords

MESOBUTHUS MARTENSII; SCORPIONES;

EID: 29844447494     PISSN: 12258687     EISSN: 12258687     Source Type: Journal    
DOI: 10.5483/bmbrep.2005.38.4.386     Document Type: Article

References (17)

1. Couraud, F., Jover, E., Dubios, J. M. and Rochat, H. (1982) Two types of scorpion toxin receptor siteds, one related to the activation, the other to the inactication of the action potential sodium channel. Toxicon 20, 9-16.
2. Corona, M., Zurita, M., Possani, L. D. and Becerril, B. (1996) Cloning and characterization of the genomic region encoding toxin IV-5 from the scorpion Tiyus serrulatus. Toxicon 34, 251-256.
3. Csank, C., Taylor, F. M. and Martindale, D. W. (1990) Nuclear pre-mRNA introns: analysis and comparison of intron sequence from Tetrdhymena thernophila and other eukaryotes. Nucleic Acids. Res. 18, 5133-5041.
4. Delabre, M. L., Pasero, P., Marilley, M. and Bougis, P. E. (1995) Promoter structure and intron-exon organization of a scorpion alpha-toxin gene. Biochemistry 34, 6729-6736.
5. Goudet, C., Chi, C. and Tytgat, J. (2002) An overview of toxins and genes from the venom of the Asian scorpion Buthus martensii Karsch. Toxicon 40, 1239-1258.
6. Goudet, C., Huys, I., Clynen, E., Schoofs, L., Wang, D., Waelkens, E. and Tytgat, J. (2001) Electrophysiological characterization of BmKM1, an alpha-like toxin from Buthus martensi Karsch venom. FEBS Lett. 495, 61-65.
7. He, X. L., Li, H. M., Zeng, Z. H., Liu, X. Q., Wang, M. and Wang, D. C. (1999) Crystalstructures of two á-like scorpion toxins: Non-proline cis peptide bonds and implications fornew binding site selectivity on the sodium channel. J. Mol. Biol. 292, 125-135.
8. Housset, D., Habersetzer-Rochat, C., Astier, J. P. and Fontecilla-Camps, J. C. (1994) Crystal structure of toxin II from the scorpion Androctonus australis Hector refined at 1.3 Åresolution. J. Mol. Biol. 238, 88-103.
9. Kopeyan, C., Martinez, G. and Rochat, H. (1985) Primary structure of toxin IV of Leiurus quinquestriatus, characterization of a new group of scorpion toxins. FEBS Lett. 181, 211-217.
10. Liu, Y., Ma, R. and Wang, S. (2003) Expression of an antitumor-analgesic peptide from the venom of Chinese scorpion Buthus martensii kirsch in Escherichia coli. Protein Expr. Purif. 27, 253-258.
11. Liu, Y., Hu, J. and Zhang, J. (2002) Isolation, purification, and N-terminal partial sequence of an antitumorpeptide from the venom of the Chinese scorpion Buthus martensii kirsch. Preparative Biochem. Biotech. 32, 317-327.
12. +-channels. Eur. J. Biochem. 264, 287-300.
13. Sambrook, J. and Russell, D. W. (2001) Molecular Cloning: A laboratory manual. 3rd. Cold Spring Harbor Laboratory Press, New York, USA.
14. Sanger, F., Nicklen, S. and Coulson, A. R. (1977) DNA seqencing with chain-termination inhibitors. Proc. Natl. Acad. Sci. USA 74, 5463-5467.
15. Xiong, Y. M., Ling, M. H., Wang, D. C. and Chi, C. W. (1997) The cDNA and genomic DNA sequences of a mammalian neurotoxin from the scorpion Buthus martensii Karsch. Toxicon 35, 1025-1031.
16. Zhu, S. Y., Li, W. X. and Zeng, X. C. (2000) Nine novel precursors of Buthus martensii scorpion a-toxin homologues. Toxicon 38, 1653-1661.
17. Zhu, S. and Li, W. X. (2002) Molecular evolution of scorpion a-toxin: accelerated evolution and function divergence. Progress Nature Scicence 12, 271-276.