Blocking transforming growth factor-β receptor signaling down-regulates transforming growth factor-β1 autoproduction in keloid fibroblasts

Chinese Journal of Traumatology - English Edition

Volumn 5, Issue 2, 2002, Pages 77-81

  Liu, Wei ^a   Cai, Zehao ^a   Wang, Danru ^a   Wu, Xiaoli ^a   Cui, Lei ^a   Shang, Qingxin ^a   Qian, Yunliang ^a   Cao, Yilin ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Keloid; Receptors; Signal transduction; Transforming growth factor beta

Indexed keywords

ADENOVIRUS VECTOR; BETA ADRENERGIC RECEPTOR; RECOMBINANT TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA; ACTIVIN RECEPTOR 1; MESSENGER RNA; TGF BETA TYPE I RECEPTOR; TGF-BETA TYPE I RECEPTOR; TRANSACTIVATOR PROTEIN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR;

ARTICLE; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; FIBROBLAST CULTURE; GENE CONTROL; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; KELOID; NORTHERN BLOTTING; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION; BIOSYNTHESIS; CELL CULTURE; COMPARATIVE STUDY; DRUG EFFECT; FIBROBLAST; GENE EXPRESSION; GENETICS; METABOLISM; SENSITIVITY AND SPECIFICITY; UPREGULATION;

ACTIVIN RECEPTORS, TYPE I; CELLS, CULTURED; DOWN-REGULATION; FIBROBLASTS; GENE EXPRESSION; HUMANS; KELOID; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; RNA, MESSENGER; SENSITIVITY AND SPECIFICITY; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS; UP-REGULATION;

EID: 29744460902     PISSN: 10081275     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (8)

1. Bettinger DA, Yager DR, Diegelmann RF, et al. The effect of TGF-beta on keloid fibroblast proliferation and collagen synthesis. Plast Reconstr Surg 1996;98:827-833.
2. Peltonen J, Hsiao LL, Jaakkola S, et al. Activation of collagen gene expression in keloids: co-localization of type I and IV collagen and transforming growth factor-beta 1 mRNA. J Invest Dermatol 1991;97:240-248.
3. Singer AJ, Clark RA. Cutaneous wound healing. N Engl J Med 1999;341:738-746.
4. Massague J, Wotton D. Transcriptional control by the TGF-beta/Smad signaling system. EMBO J 2000;19:1745-1754.
5. Yamamoto H, Ueno H, Ooshima A, et al. Adenovirus-mediated transfer of a truncated transforming growth factor-beta (TGF-beta) type II receptor completely and specifically abolishes diverse signaling by TGF-beta in vascular wall cells in primary culture. J Biol Chem 1996;271:16253-16259.
6. Li DQ, Lee SB, Tseng SC. Differential expression and regulation of TGF-beta1, TGF-beta2, TGF-beta3, TGF-betaRI, TGF-betaRII and TGF-betaRIII in cultured human corneal, limbal, and conjunctival fibroblasts. Curr Eye Res 1999;19:154-161.
7. Lee TY, Chin GS, Kim WJ, et al. Expression of transforming growth factor beta 1, 2, and 3 proteins in keloids. Ann Plast Surg 1999;43:179-184.
8. Rao JN, Li L, Bass BL, et al. Expression of the TGF-β receptor gene and sensitivity to growth inhibition following polyamine depletion. Am J Rysiol Cell Physiol 2000;279:c1034-1044.