Influence of oxygen concentration on redox cycling of alloxan and dialuric acid

Hormone and Metabolic Research

Volumn 37, Issue 12, 2005, Pages 729-733

  Brömme, Hans Jürgen ^a   Weinandy, R ^a   Peschke, E ^a  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

Chemical diabetes; GSH; HPLC; ROS

Indexed keywords

ALLOXAN; ARGON; DIALURIC ACID; GLUTATHIONE; OXYGEN; REACTIVE OXYGEN METABOLITE;

AIR; ARTICLE; CALCULATION; CONCENTRATION (PARAMETERS); DECOMPOSITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IN VITRO STUDY; INSULIN DEFICIENCY; NONHUMAN; OXIDATION; OXIDATION REDUCTION REACTION; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; TEMPERATURE;

ALLOXAN; BARBITURATES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUTATHIONE; KINETICS; OXIDATION-REDUCTION; OXYGEN; REACTIVE OXYGEN SPECIES; STATISTICS, NONPARAMETRIC;

EID: 29744458623     PISSN: 00185043     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2005-921093     Document Type: Article

References (23)

1. Resnik R, Wolff A. The reaction of alloxan with glutathione and protein. Arch Biochem Biophys 1956; 64: 33-50
2. Patterson J, Lazarow A, Levey S. Alloxan and dialuric acid: their stabilities and ultraviolet absorption spectra. J Biol Chem 1949; 177: 187-196
3. Halliwell B, Gutteridge JMC. Free Radicals in Biology and Medicine. Third Edition ed. Oxford: Oxford University Press, 1999
4. Lenzen S, Fanten U. Alloxan: history and mechanism of action. Diabetologia 1988; 31: 337-342
5. Munday R. Dialuric acid autoxidation. Effects of transition metals on the reaction rate and on the generation of "active oxygen" species. Biochem Pharmacol 1988; 37: 409-413
6. Oberley LW. Free radicals and diabetes. Free Radic Biol Med 1988; 5: 113-124
7. Brömme HJ, Peschke E. Molekulare Mechanismen der Alloxan-Toxizität sowie die radikalfangende und antidiabetogene Bedeutung von Melatonin. Abhandlungen der Sächsischen Akademie der Wissen-schaften zu Leipzig. Mathematisch-naturwissenschaftliche Klasse 2003; 60: 137-162
8. Brömme HJ et al. Simultaneous quantitative determination of alloxan, GSH and GSSG by HP1c. Estimation of the frequency of redox cycling between alloxan and dialuric acid. Horm Metab Res 2001; 33: 106-109
9. Winterbourn C, Cowden W, Sutton H. Auto-oxidation of dialuric acide, divicine and isouramil. Superoxide dependent and independent mechanism. Biochem Pharmacol 1989; 38: 611-618
10. Washburn M, Wells W. Glutathion dependent reduction of alloxan to dialuric acid catalyzed by thioltransferase (glutaredoxin): a possible role for thioltransferase in alloxan toxicity. Free Radical Biol Med 1997; 23: 563-570
11. Lenzen S, Munday R. Thiol-group reactivity, hydrophilicity and stability of alloxan, its reduction products and its N-methyl derivatives and comparison with ninhydrin. Biochem Pharmacol 1991; 42: 1385-1391
12. 2+ homeostasis and respiration. Biosci Rep 1997; 17: 53-66
13. Gnaiger E et al. Mitochondrial respiration in the low oxygen environment of the cell. Effect of ADP on oxygen kinetics. Biochim Biophys Acta 1998; 1365: 249-254
14. Frerichs H, Creutzfeldt W. Der experimentelle chemische Diabetes. In: Dörzbach E(ed). Handbuch der experimentellen Pharmakologie, Insulin Teil 1. Berlin, Heidelberg, New York: Springer Verlag, 1971: 159-202
15. Jones DP, Brown LA, Sternberg P. Variability in glutathione-dependent detoxication in vivo and its relevance to detoxication of chemical mixtures. Toxicology 1995; 105: 267-274
16. Naidu KA. Vitamin C in human health and disease is still a mystery? An overview. Nitrition J 2003; 2: 1-10
17. Navarro J et al. Blood glutathione as an index of radiation-induced oxidative stress in mice and humans. Free Radic Biol Med 1997; 22: 1203-1209
18. Gomori G, Goldner M. Acute nature of alloxan damage. Proc Soc exp Biol (N.Y.) 1945; 58: 232-233
19. Weaver DC, McDaniel M, Lacy PE. Alloxan uptake by isolated islets of Langerhans. Endocrinology 1978; 102: 1874-1855
20. Elsner M et al. Importance of the GLUT2 glucose transporter for pancreatic beta cell toxicity of alloxan. Diabetologia 2002; 45: 1542-1549
21. Elsner M, Tiedge M, Lenzen S. Mechanism underlying resistance of human pancreatic beta cells against toxicity of streptozotocin and alloxan. Diabetologia 2003; 46: 1713-1714
22. Brömme HJ et al. Alloxan acts as a prooxidant only under reducing conditions: influence of melatonin. Cell Mol Life Sci 1999; 55: 487-493
23. Lenzen S, Drinkgern J, Tiedge M. Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues. Free Radic Biol Med 1996; 20: 463-466