Role of intergenic human γ-δ-globin sequences in human hemoglobin switching and reactivation of fetal hemoglobin in adult erythroid cells

Annals of the New York Academy of Sciences

Volumn 1054, Issue , 2005, Pages 48-54

  Bank, Arthur ^a   O'Neill, David ^b   Lopez, Rocio ^c   Pulte, Dianne ^d   Ward, Maureen ^a   Mantha, Simon ^a   Richardson, Christine ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b NEW YORK UNIVERSITY   (United States)

^c Erimos Pharmaceuticals   (United States)

^d VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Fetal hemoglobin; Human hemoglobin switching; PYR complex

Indexed keywords

DELTA GLOBIN; GAMMA GLOBIN; HEMOGLOBIN F; PYRIMIDINE DERIVATIVE;

ADULT; ANEMIA; BETA THALASSEMIA; BINDING SITE; CHROMATIN ASSEMBLY AND DISASSEMBLY; COMPLEX FORMATION; CONFERENCE PAPER; DISEASE SEVERITY; EMBRYO CELL; ERYTHROID CELL; FETUS CELL; GENE ACTIVATION; GENE DELETION; GENE LOSS; GENE SEQUENCE; GENE SWITCHING; GLOBIN GENE; HEMATOPOIESIS; HEMATOPOIETIC CELL; HOMOZYGOSITY; HUMAN; HUMAN CELL;

EID: 29744442892     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1345.057     Document Type: Conference Paper

References (9)

1. VAKOC, C.R., D.L. LETTING, N. GHELDOF, et al. 2005. Proximity among distant regulatory elements at the β-globin locus requires GATA-1 and FOG-1. Mol. Cell 17: 453-462.
2. FORGET, B.G. 1998. Molecular basis of hereditary persistence of fetal hemoglobin. Ann. N.Y. Acad. Sci. 850: 38-44.
3. KATSANTONI, E.Z., A. LANGEVELD, A.W. WAI, et al. 2003. Persistent γ-globin expression in adult transgenic mice is mediated by HPFH-2, HPFH-3, and HPFH-6 breakpoint sequences. Blood 102: 3412-3419.
4. CHAKALOVA, L., C.S. OSBORNE, Y.F. DAI, et al. 2005. The Corfu δβ thalassemia deletion disrupts γ-globin gene silencing and reveals post-transcriptional regulation of HbF expression. Blood 105: 2154-2160.
5. O'NEILL, D., K. BORNSCHLEGEL, M. FLAMM, et al. 1991. A DNA-binding factor in adult hematopoietic cells interacts with a pyrimidine-rich domain upstream from the human δ-globin gene. Proc. Natl. Acad. Sci. USA 88: 8953-8957.
6. O'NEILL, D., J. YANG, H. ERDJUMENT-BROMAGE, et al. 1999. Tissue-specific and developmental stage-specific binding of a SWI/SNF complex associated with human fetal to adult globin switching. Proc. Natl. Acad. Sci. USA 96: 349-354.
7. O'NEILL, D., S. SCHOETZ, R. LOPEZ, et al. 2000. An Ikaros-containing chromatin-remodeling complex in adult-type erythroid cells. Mol. Cell. Biol. 20: 7572-7582.
8. LOPEZ, R.A., S. SCHOETZ, K. DEANGELIS, et al. 2002. Multiple hematopoietic defects and delayed globin switching in Ikaros null mice. Proc. Natl. Acad. Sci. USA 99: 602-607.
9. GRIBNAU, J., K. DIDERICH, S. PRUZINA, et al. 2000. Intergenic transcription and developmental remodeling of chromatin subdomains in the human β-globin locus. Mol. Cell 5: 377-386.