Chimeric recombinant human metapneumoviruses with the nucleoprotein or phosphoprotein open reading frame replaced by that of avian metapneumovirus exhibit improved growth in vitro and attenuation in vivo

Journal of Virology

Volumn 79, Issue 24, 2005, Pages 15114-15122

  Pham, Quynh N ^a   Biacchesi, Stéphane ^a   Skiadopoulos, Mario H ^a   Murphy, Brian R ^a   Collins, Peter L ^a   Buchholz, Ursula J ^a,b  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b MSC 8007 ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LIVE VACCINE; NEUTRALIZING ANTIBODY; NUCLEOPROTEIN; PHOSPHOPROTEIN;

ANIMAL CELL; ANTIGENIC VARIATION; ARTICLE; AVIAN PNEUMOVIRUS; CERCOPITHECIDAE; CHIMERA; CONTROLLED STUDY; GENE EXPRESSION; GENETIC MANIPULATION; HAMSTER; HUMAN METAPNEUMOVIRUS; IMMUNITY; IMMUNIZATION; IMMUNOGENICITY; IN VITRO STUDY; IN VIVO STUDY; LOWER RESPIRATORY TRACT; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PRIORITY JOURNAL; RECOMBINANT HUMAN METAPNEUMOVIRUS; TURBINATE; UPPER RESPIRATORY TRACT; VERO CELL; VIROGENESIS; VIRUS ATTENUATION; VIRUS LOAD; VIRUS RECOMBINANT; VIRUS REPLICATION;

ANIMALS; CERCOPITHECUS AETHIOPS; CRICETINAE; GENE DELETION; GENES, VIRAL; HUMANS; METAPNEUMOVIRUS; NUCLEOPROTEINS; OPEN READING FRAMES; PHOSPHOPROTEINS; RECOMBINANT FUSION PROTEINS; RECOMBINATION, GENETIC; VERO CELLS; VIRAL VACCINES; VIRULENCE; VIRUS REPLICATION;

ANIMALIA; AVIAN METAPNEUMOVIRUS; CERCOPITHECIDAE; CERCOPITHECUS AETHIOPS; CRICETINAE; HUMAN METAPNEUMOVIRUS; MAMMALIA;

EID: 29744436425     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.79.24.15114-15122.2005     Document Type: Article

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