Evaluation of bivalent live attenuated influenza A vaccines in children 2 months to 3 years of age: Safety, immunogenicity and dose-response

Vaccine

Volumn 15, Issue 12-13, 1997, Pages 1379-1384

  Gruber, William C ^a   Darden, Paul M ^c   Still, J Gordon ^d   Lohr, Jacob ^e   Reed, George ^a   Wright, Peter F ^a,b  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Wyeth Ayerst ca Influenza Vacc S   (United States)

^c MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^d DUKE UNIVERSITY MEDICAL CENTER   (United States)

^e UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INFLUENZA VACCINE;

ANTIBODY RESPONSE; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; HUMAN; HUMAN EXPERIMENT; IMMUNE RESPONSE; IMMUNOGENICITY; INFANT; INFLUENZA VIRUS A; INTRANASAL DRUG ADMINISTRATION; PRESCHOOL CHILD; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SEROCONVERSION;

ANTIBODIES, VIRAL; CHILD, PRESCHOOL; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; DOUBLE-BLIND METHOD; HUMANS; INFANT; INFLUENZA A VIRUS; INFLUENZA VACCINES; VACCINES, ATTENUATED;

EID: 0030884809     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0264-410X(97)00032-7     Document Type: Article

References (26)

1. Arden, N.H., Cox, N.J. and Schonberger, L.B. Prevention and control of influenza: Part I, Vaccines. Recommendations of the advisory committee on Immunization practices (ACIP). MMWR 1994, 43, 1-13.
2. Frank, A.L., Taber, L.H. and Wells, J.M. Comparison of infection rates and severity of illness for influenza A subtypes H1N1 and H3N2. Journal of Infectious Diseases 1985, 151, 73-80.
3. Kim, H.W., Brandt, C.D. and Arrobio, J.O. et al. Influenza A and B virus infection in infants and young children during the years 1957-1976. American Journal of Epidemiology 1979, 109, 464-479.
4. Monto, A.S., Davenport, F.M. and Napier, S.A. et al. Effect of vaccination of a school-age population upon the course of an A2/Hong Kong influenza epidemic. Bulletins of the World Health Organization 1969, 41, 537-542.
5. Wright, P.F., Thompson, J. and Vaught, W.K. et al. Trials of influenza A/New Jersey/76 virus vaccine in normal children: an overview of age-related antigenicity and reactogenicity. Journal of Infectious Diseases 1977, 136, S731-S741.
6. Wright, P.F., Cherry, J.D. and Fox, H.M. et al. Antigenicity and reactogenicity of influenza A/USSR/77 virus vaccines in children. Review of Infectious Diseases 1983, 5, 758-764.
7. Groothuis, J.R., Levin, M.J. and Rabalais, G.P. et al. Immunization of high-risk infants younger than 18 months of age with split-product influenza vaccine. Pediatrics 1991, 87, 823-828.
8. Piedra, P.A., Glezen, W.P. and Mbawuike, I. et al. Studies on reactogenicity and immunogenicity of attenuated bivalent cold recombinant influenza type A (CRA) and inactivated trivalent influenza virus (TI) vaccines in infants and young children. Vaccine 1993, 11, 718-724.
9. Maassab, H.F. Adaptation and growth characteristics of influenza virus at 25E C. Nature 1967, 213, 612-614.
10. Maassab, H.F., Kendal, A.P., Abrams, G.D. and Monto, A.S. Evaluation of a cold-recombinant influenza virus vaccine in ferrets. Journal of Infectious Diseases 1982, 146, 780-790.
11. Cox, N.F., Maassab, H.F. and Kendal, A.P. Comparative studies of wild-type and cold mutant (temperature-sensitive) influenza viruses: nonrandom reassortment of genes during preparation of live virus vaccine candidates by recombination at 25E between recent H3N2 and H1N1 epidemic strain and cold-adapted A/Ann Arbor/6/60. Virology 1979, 97, 190-194.
12. Davenport, F.M., Hennessy, A.V. and Maassab, H.F. et al. Pilot studies on recombinant cold-adapted live type A and B influenza virus vaccines. Journal of Infectious Diseases 1977, 136, 17-25.
13. Wright, P.F., Okabe, N. and McKee, K.T.J. et al. Cold-adapted recombinant influenza A virus vaccines in seronegative young children. Journal of Infectious Diseases 1982, 146, 71-79.
14. Feldman, S., Wright, P.F. and Webster, R.G. et al. Use of influenza A virus vaccines in seronegative children: live cold-adapted versus inactivated whole virus. Journal of Infectious Diseases 1985, 152, 1212-1218.
15. Wright, P.F. and Karzon, D.T. Live attenuated influenza vaccines.. Progress in Medical Virology 1987, 34, 70-88.
16. Belshe, R.B., Van Voris, L.P. and Bartram, J. et al. Live attenuated influenza A virus vaccines in children: results of a field trial. Journal of Infectious Diseases 1984, 150, 834-840.
17. Gruber, W.C., Kirschner, K. and Tollefson, S. et al. Comparison of monovalent and trivalent live attenuated influenza vaccines in young children. Journal of Infectious Diseases 1993, 168, 53-60.
18. Edwards, K.M., King, J.C. and Steinhoff, M.C. et al. Safety and immunogenicity of live attenuated cold-adapted influenza B/Ann Arbor/1/86 reassortant virus vaccine in infants and children. Journal of Infectious Diseases 1991, 163, 740-745.
19. Wright, P.F., Bhargava, M., Johnson, P.R., Thompson, J. and Karzon, D.T. Simultaneous administration of live, attenuated influenza A vaccines representing different serotypes. Vaccine 1985, 3, 305-308.
20. Gruber, W.C., King, J.C., Kirschner, K.F. et al., Evaluation of live attenuated monovalent and bivalent influenza vaccine in seronegative children. Abstract # 415. In Program and Abstracts of the Twenty-eighth Interscience Conference on Antimicrobial Agents and Chemotherapy, Los Angeles, CA, 1988, p. 182
21. Belshe, R.B., Swierkosz, E.M., Anderson, E.L., Newman, F.K., Nugent, S.L. and Maassab, H.F. Immunization of infants and young children with live attenuated trivalent cold-recombinant influenza A H1N1, H3N2, and B vaccine. Journal of Infectious Diseases 1992, 165, 727-732.
22. Swierkosz, E.M., Newman, F.K. and Anderson, E.L. et al. Multidose, live attenuated, cold-recombinant, trivalent influenza vaccine in infants and young children. Journal of Infectious Diseases 1994, 169, 1121-1124.
23. Edwards, K.M., Dupont, W.D. and Westrich, M.K. et al. A randomized controlled trial of cold-adapted and inactivated vaccines for the prevention of influenza A disease. Journal of Infectious Diseases 1994, 169, 68-76.
24. Gruber, W.C., Belshe, R.B., King, J.C., Treanor, J.J. and Piedra, P.A. Wyeth-Ayerst CA influenza Vaccine Investigators Group. Evalution of live attenuated influenza vaccines in children 6-18 months of age: safety, immunogenicity, and efficacy. Journal of Infectious Diseases 1996, 143, 1313-1319.
25. Karron, R.A., Steinhoff, M.D. and Subbarao, E.K. et al. Safety and immunogenicity of a cold-adapted influenza A (H1N1) reassortant virus vaccine administered to infants less than six months of age. Pediatric Infectious Diseases 1995, 14, 10-16.
26. Clements, M.L., Makhene, M.K. and Karron, R.A. et al. Effective immunization with live attenuated influenza A virus can be achieved in early infancy. Journal of Infectious Diseases 1996, 173, 44-51.