Metabolism of aminoguanidine, diaminoguanidine, and NG-amino-L- arginine by neuronal NO-synthase and covalent alteration of the heme prosthetic group

Chemical Research in Toxicology

Volumn 18, Issue 12, 2005, Pages 1927-1933

  Lee, Anthony J ^a   Noon, Kathleen R ^a   Jianmongkol, Suree ^a   Lau, Miranda ^a   Jenkins, Gary J ^a   Osawa, Yoichi ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOGUANIDINE; ARGININE DERIVATIVE; CARBON 14; CYTOCHROME P450; DIAMINOGUANIDINE; GUANIDINE DERIVATIVE; HEME; HYDRAZINE; MICROSOME ENZYME; N(G) AMINOARGININE; NEURONAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL MODIFICATION; COMPUTER ANALYSIS; COMPUTER PROGRAM; COVALENT BOND; COVALENT MODIFICATION; DIFFERENTIAL METABOLIC PROFILING; DRUG METABOLISM; ENZYME INACTIVATION; ENZYME SUBSTRATE; ISOTOPE LABELING; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MOLECULAR WEIGHT; OXIDATION;

ARGININE; CELLS, CULTURED; ENZYME ACTIVATION; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; GUANIDINES; HEME; MODELS, CHEMICAL; MOLECULAR STRUCTURE; NITRIC OXIDE SYNTHASE TYPE I;

EID: 29644441043     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx050263c     Document Type: Article

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