Characterization of the humoral immune response to glutamic acid decarboxylase in patients with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) and/or type 1 diabetes

European Journal of Endocrinology

Volumn 153, Issue 6, 2005, Pages 901-906

  Ronkainen, Matti S ^c   Härkönen, Taina ^a   Perheentupa, Jaakko ^a   Knip, Mikael ^a,b  

^a UNIVERSITY OF HELSINKI   (Finland)

^b TAMPERE UNIVERSITY HOSPITAL   (Finland)

^c UNIVERSITY OF OULU   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; GLUTAMATE DECARBOXYLASE 65; GLUTAMATE DECARBOXYLASE 65 ANTIBODY; GLUTAMATE DECARBOXYLASE 67; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2; IMMUNOGLOBULIN G4; IMMUNOGLOBULIN SUBCLASS;

ADOLESCENT; ADULT; AMINO TERMINAL SEQUENCE; ANTIBODY DETECTION; ARTICLE; AUTOIMMUNE POLYENDOCRINOPATHY CANDIDIASIS ECTODERMAL DYSTROPHY; BLOOD SAMPLING; CARBOXY TERMINAL SEQUENCE; CHILD; CLINICAL ARTICLE; CONFIDENCE INTERVAL; CONTROLLED STUDY; DIFFERENTIAL DIAGNOSIS; DISEASE ASSOCIATION; FEMALE; HUMAN; HUMORAL IMMUNITY; IMMUNE RESPONSE; IMMUNOREACTIVITY; INSULIN DEPENDENT DIABETES MELLITUS; MALE; PRIORITY JOURNAL; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE;

ADULT; ANTIBODY FORMATION; AUTOANTIBODIES; CHILD, PRESCHOOL; DIABETES MELLITUS, TYPE 1; EPITOPES; FEMALE; GLUTAMATE DECARBOXYLASE; HUMANS; IMMUNOGLOBULIN G; ISOENZYMES; MALE; MIDDLE AGED; POLYENDOCRINOPATHIES, AUTOIMMUNE;

EID: 29644439025     PISSN: 08044643     EISSN: None     Source Type: Journal    
DOI: 10.1530/eje.1.02026     Document Type: Article

References (27)

1. Leslie RDG, Atkinson MA & Notkins AL. Autoantigens IA-2 and GAD in type I (insulin-dependent) diabetes. Diabetologia 1999 42 3-14.
2. Velloso LA, Winqvist O, Gustafsson J, Kämpe O & Karlsson EA. Autoantibodies against a novel 51 kDa islet antigen and glutamate decarboxylase isoforms in autoimmune polyendocrine syndrome type I. Diabetologia 1994 37 61-69.
3. Christie MR, Genovese S, Cassidy D, Bosi E, Brown TJ, Lai M, Bonifacio E & Bottazzo G. Antibodies to islet 37k antigen, but not to glutamate decarboxylase, discriminate rapid progression to IDDM in endocrine autoimmunity. Diabetes 1994 43 1254-1259.
4. Vianello M, Tavolato B & Giometto B. Glutamic acid decarboxylase autoantibodies and neurological disorders. Neurological Sciences 2002 23 145-151.
5. Karlsen AE, Hagopian WA, Grubin CE, Dube S, Disteche CM, Adler DA, Bärmeier H, Mathews S, Grant FJ, Foster D & Lernmark Å. Cloning and primary structure of a human islet isoform of glutamic acid decarboxylase from chromosome 10. PNAS 1991 88 8337-8341.
6. Bu DF, Erlander MG, Hitz BC, Tillakaratne NJK, Kaufman DL, Wagner-McPherson B, Evans GA & Tobin AJ. Two human glutamate decarboxylases, 65-kDa GAD and 67-kDa GAD, are each encoded by a single gene. PNAS 1992 89 2115-2119.
7. Ujihara N, Daw K, Gianani R, Boel E, Yu L & Powers AC. Identification of glutamic acid decarboxylase autoantibody heterogeneity and epitope regions in type 1 diabetes. Diabetes 1994 43 968-975.
8. Tuomi T, Björses P, Falorni A, Partanen J, Perheentupa J, Lernmark Å & Miettinen A. Antibodies to glutamic acid decarboxylase and insulin-dependent diabetes in patients with autoimmune polyendocrine syndrome type I. Journal of Clinical Endocrinology and Metabolism 1996 81 1488-1494.
9. Björses P, Aaltonen J, Horelli-Kuitunen N, Yaspo ML & Peltonen L. Gene defect behind APECED: a new clue to autoimmunity. Human Molecular Genetics 1998 7 1547-1553.
10. Ahonen P, Myllärniemi S, Sipilä I & Perheentupa J. Clinical variation of autoimmune polyendocrinopathy-candidas-ectodermal dystrophy (APECED) in a series of 68 patients. New England Journal of Medicine 1990 322 1829-1836.
11. Perheentupa J. APS-1/APECED: the clinical disease and therapy. Endocrinology and Metabolism Clinics of North America 2002 31 295-320.
12. Gylling M, Tuomi T, Björses P, Kontiainen S, Partanen J, Christie MR, Knip M, Perheentupa J & Miettinen A. β-Cell autoantibodies, human leukocyte antigen II alleles, and type 1 diabetes in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. Journal of Clinical Endocrinology and Metabolism 2000 85 4434-4440.
13. Kulmala P, Savola K, Petersen JS, Vähäsalo P, Karjalainen J, Löppönen T, Dyrberg T, Åkerblom HK Knip M & the Childhood Diabetes in Finland Study Group. Prediction of insulin-dependent diabetes mellitus in siblings of children with diabetes - a population based study. Journal of Clinical Investigation 1998 101 327-336.
14. Richter W, Shi Y & Baekkeskov S. Autoreactive epitopes defined by diabetes-associated human monoclonal antibodies are localized in the middle and C-terminal domains of the smaller form of glutamate decarboxylase. PNAS 1993 90 2832-2836.
15. Falorni A, Ackefors M, Carlberg C, Daniels T, Persson B, Robertson J & Lernmark Å. Diagnostic sensitivity of immunodominant epitopes of glutamic acid decarboxylase (GAD65) autoantibodies in childhood IDDM. Diabetologia 1996 39 1091-1098.
16. Schwartz HL, Chandonia J-M, Kash SF, Kanaani J, Tunnell E, Domingo A, Cohen FE, Banga JP, Madec A-M, Richter W & Baekkeskov S. High-resolution autoreactive epitope mapping and structural modeling of the 65 kDa form of human glutamic acid decarboxylase. Journal of Molecular Biology 1999 287 983-999.
17. Bonifacio E, Lampasona V, Bernasconi I & Ziegler AG. Maturation of the humoral response to epitopes of GAD in preclinical childhood type 1 diabetes. Diabetes 2000 49 202-208.
18. Bonifacio E, Scirpoli M, Kredel K, Füchtenbusch M & Ziegler AG. Early autoantibody responses in prediabetes are IgG1 dominated and suggest antigen-specific regulation. Journal of Immunology 1999 163 525-532.
19. Björk E, Velloso LA, Kämpe O & Karlsson FA. GAD autoantibodies in IDDM, stiff-man syndrome, and autoimmune polyendocrine syndrome type I recognise different epitopes. Diabetes 1994 43 161-165.
20. Sabbah E, Savola K, Ebeling T, Kulmala P, Vähäsalo P, Salmela PI, Ilonen J & Knip M. Genetic, autoimmune and clinical characteristics of childhood and adult onset type 1 diabetes. Diabetes Care 2000 23 1326-1332.
21. Savola K, Sabbah E, Kulmala P, Vähäsalo P, Ilonen J & Knip M. Autoantibodies associated with type 1 diabetes mellitus persist after diagnosis in children. Diabetologia 1998 41 1293-1297.
22. Hoppu S, Ronkainen MS, Kulmala P, Åkerblom HK Knip M & the Childhood Diabetes in Finland Study Group. GAD65 antibody isotypes and epitope recognition during the prediabetec process in siblings of children with type I diabetes. Clinical and Experimental Immunology 2004 136 120-128.
23. Solimena M, Folli F, Aparisi R, Pozza G & De Camilli P. Autoantibodies to GABA-ergic neurons and pancreatic beta cells in stiffman syndrome. New England Journal of Medicine 1990 322 1555-1560.
24. 2-terminal epitope in the autoantigen GAD65, distinguish stiff-man syndrome from insulin-dependent diabetes mellitus. Journal of Experimental Medicine 1994 180 595-606.
25. Couper JJ, Harrison LC, Aldis JJE, Colman PG, Honeyman MC & Ferrante A. IgG subclass antibodies to glutamic acid decarboxylase and risk for progression to clinical insulin-dependent diabetes. Human Immunology 1998 59 493-499.
26. Petersen JS, Kulmala P, Clausen JT, Knip M Dyrberg T & the Childhood Diabetes in Finland Study Group. Progression to type 1 diabetes is associated with a change in the immunoglobulin isotype profile of autoantibodies to glutamic acid decarboxylase (GAD65). Clinical Immunology 1999 90 276-281.
27. Hawa MI, Fava D, Medici F, Deng Y-J, Notkins AL, De Mattia G & Leslie RDG. Antibodies to IA-2 and GAD65 in type 1 and type 2 diabetes. Diabetes Care 2000 23 228-233.