Ultrastructural observation of effect of moderate hypothermia on axonal damage in an animal model of diffuse axonal injury

Chinese Journal of Traumatology - English Edition

Volumn 5, Issue 6, 2002, Pages 355-360

  Sun, Xiaochuan ^a   Tang, Wenyuan ^a   Zheng, Lüping ^a  

^a CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

Axons; Cytoskeleton; Diffuse axonal injury; Hypothermia

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DAMAGE; CONTROLLED STUDY; CORE TEMPERATURE; CYTOSKELETON; DIFFUSE AXONAL INJURY; DISEASE COURSE; DISEASE SEVERITY; HYPOTHERMIA; MICROTUBULE; NEUROFILAMENT; NONHUMAN; OPTIC NERVE FIBER; QUANTITATIVE ANALYSIS; TRANSMISSION ELECTRON MICROSCOPY; ULTRASTRUCTURE; ANIMAL; COMPARATIVE STUDY; CRYOANESTHESIA; CULTURE TECHNIQUE; DISEASE MODEL; ELECTRON MICROSCOPY; GUINEA PIG; MALE; METHODOLOGY; NERVE FIBER; OPTIC NERVE; OPTIC NERVE INJURY; PATHOLOGY; PROBABILITY; RANDOMIZATION; REFERENCE VALUE;

ANIMALS; AXONS; CULTURE TECHNIQUES; DIFFUSE AXONAL INJURY; DISEASE MODELS, ANIMAL; GUINEA PIGS; HYPOTHERMIA, INDUCED; MALE; MICROSCOPY, ELECTRON; OPTIC NERVE; OPTIC NERVE INJURIES; PROBABILITY; RANDOM ALLOCATION; REFERENCE VALUES;

EID: 29644437760     PISSN: 10081275     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Sun XC, Maxwell WL, Graham DI, et al. Ultrastructural study of Node of Ranvier in early stage of axonal injury of optic nerve. Chin J Traumatol 1999;15:422-425.
2. Povlishock JT, Christman CW. The pathobiology of traumatically induced axonal injury in animals and humans: a review of current thoughts. J Neurotrauma 1995;12:555-564.
3. Maxwell WL, Povlishock JT, Graham DI. A mechanistic analysis of non-disruptive axonal injury: a review. J Neurotrauma 1997;14:419-440.
4. Marion DW, White MJ. Treatment of experimental brain injury with moderate hypothermia and 21-aminosteroids. J Neurotrauma 1996;13:139-147.
5. Koizumi H, Povlishock JT. Posttraumatic hypothermia in the treatment of axonal damage in an animal model of traumatic axonal injury. J Neurosurg 1998;89:303-309.
6. Gaskin F, Cantor CR, Shelanski ML. Biochemical studies on in vitro assembly and disassembly of microtubules. Ann NY Acad Sci 1975;253:133-146.
7. Maxwell WL, McCreath BJ, Graham DI, et, al. Cytochemical evidence for redistribution of membrane pump calcium-ATPase and ecto-Ca-ATPase activity, and calcium influx in myelinated nerve fibers of the optic nerve after stretch injury. J Neurocytol 1995;24:925-942.
8. Job D, Fischer EH, Margolis RL. Rapid disassembly of cold-stable microtubules by calmodulin. Proc Natl Acad Sci USA 1981;78:4679-4682.
9. Mitani A, Kadoya F, Kataoka K. Temperature dependence of hypoxia-induced calcium accumulation in gerbil hippocampal slices. Brain Res 1991;562:159-163.
10. Widmann R, Miyazaawa T, Hossmann KA. Protective effect of hypothermia on hippocampal injury after 30 minutes of forebrain ischemia in rats is mediated by post ischemic recovery of protein synthesis. J Neurochem 1993;61:200-209.