Milrinone and low cardiac output following cardiac surgery in infants: Is there a direct myocardial effect?

Pediatric Cardiology

Volumn 26, Issue 5, 2005, Pages 642-645

  Duggal, B ^a   Pratap, U ^a   Slavik, Z ^a   Kaplanova, J ^b   Macrae, D ^a  

^a ROYAL BROMPTON HOSPITAL   (United Kingdom)

^b UNIVERSITY HOSPITAL HRADEC KRALOVE   (Czech Republic)

Author keywords

Cardiac surgery; Infants; Low cardiac output; Milrinone; Myocardial function

Indexed keywords

MILRINONE;

ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; DOPPLER ECHOCARDIOGRAPHY; DRUG EFFECT; FORWARD HEART FAILURE; HEART FUNCTION; HEART INDEX; HEART LEFT VENTRICLE EJECTION TIME; HEART OUTPUT; HEART RATE; HEART SURGERY; HUMAN; INFANT; INTENSIVE CARE UNIT; OPEN STUDY; PEDIATRIC SURGERY; POSTOPERATIVE COMPLICATION; PRESCHOOL CHILD;

CARDIAC OUTPUT, LOW; CARDIAC SURGICAL PROCEDURES; CARDIOTONIC AGENTS; ECHOCARDIOGRAPHY, DOPPLER; HEART RATE; HUMANS; INFANT; INFUSIONS, INTRAVENOUS; MILRINONE; MYOCARDIAL CONTRACTION; PROSPECTIVE STUDIES; STROKE VOLUME; TREATMENT OUTCOME;

EID: 29544450108     PISSN: 01720643     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00246-005-0881-z     Document Type: Article

References (25)

1. ABPI Compendium of Data Sheets and Summaries of Product Characteristics 1999-2000 (1999). Datapharm, London, p 1419
2. Barton P, sGarcia J, Kouatli A, et al. (1996) Hemodynamic effects of IV milrinone lactate in pediatric patients with septic shock. A prospective, double-blinded, randomized, placebo-controlled, interventional study. Chest 109:1302-1312
3. Chanani NK, Cowan DB, Takeuchi K, et al (2002) Differential effects of amrinone and milrinone upon myocardial inflammatory signaling. Circulation 106 (Suppl 1):284-289
4. Chang AC, Atz AM, Wernovsky G, Burke RP, Wessel DL (1995) Milrinone: systemic and pulmonary hemodynamic effects in neonates after cardiac surgery. Grit Care Med 23:1907-1914
5. Chatterjee K (1989) Phosphodiesterase inhibitors: alterations in systemic and coronary hemodynamics. Basic Res Cardiol 84 (Suppl 1):213-224
6. Eidem BW, O'Leary PW, Tei C, Seward JB (2000) Usefulness of the myocardial performance index in assessing right ventricular function in congenital heart disease. Am J Cardiol 86:654-658
7. Eidem BW, Tei C, O'Leary PW, Cetta F, Seward JB (1998) Nongeometric quantitative assessment of right and left ventricular function: myocardial performance index in normal children and patients with Ebstein's anomaly. J Am Soc Echocardiogr 11:849-856
8. Hiramatsu N, Kageyama K (2003) Anti-thrombotic effect of milrinone is caused by inhibition of calcium release from the dense tubular system in human platelets. Acta Anaesthesiol Scand 47:53-57
9. Hoffman TM, Wernovsky G, Atz AM, et al. (2003) Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease. Circulation 107:996-1002
10. Holmberg SR, Williams AJ (1991) Phosphodiesterase inhibitors and the cardiac sarcoplasmic reticulum calcium release channel: differential effects of milrinone and enoximone. Cardiovasc Res 25:537-545
11. Ishii M, Eto G, Tei C, et al. (2000) Quantitation of global right ventricular function in children with normal heart and congenital heart disease: a right ventricular myocardial performance index. Pediatr-Cardiol 21:416-421
12. Katz AM (1990) Interplay between inotropic and lusitropic effects of cyclic adenosine monophosphate on the myocardial cell. Circulation 82 (Suppl 2):7-11
13. Kauffman RF, Schenk KW, Utterback BG, Crowe VG, Cohen ML (1987) In vitro vascular relaxation by new inotropic agents: relationship to phospfiodiesterase inhibition and cyclic nucleotides. J Pharmacol Exp Ther 242:864-872
14. Kumar A, Kosuri R, Kandula P, et al. (1999) Effects of epinephrine and amrinone on contractility and cyclic adenosine monophospahte generation of tumor necrosis factor alpha-exposed cardiac myocytes. Crit Care Med 27:286-292
15. LaCorte JC, Cabreriza SE, Rabkin DG, et al (2003) Correlation of Tei index with invasive measurements of ventricular function in porcine model. J Am Sosc Echocardiogr 16:442-447
16. Libonati JR, Ciccolo J, Glassber GH (2001) The Tei index and exercise capacity. J Sports Med Phys Fitness 41:108-113
17. Parr GVS, Blackstone EH, Kirklin JW (1975) Cardiac performance and mortality early after intracardiac surgery in infants and young children. Circulation 51:867-874
18. Polla B, Capelli V, Canepari M, Zanardi MC, Reggiani C (1995) Direct depressant effect of phosphodiesterase inhibitors on ATPase activity of cardiac myofibrils. Can J Physiol Pharmacol 73:661-664
19. Ravishankar C, Tabbutt S, Wernovsky G (2003) Critical care in cardiovacsular medicine. Curr Opin Pediatr 15:443-453
20. Ringe HIG, Varnholt V, Gaedicke G (2003) Cardiac rescue with enoximone in volume and catecholamine refractory septic shock. Pediatr Grit Care Med 4:471-475
21. Saatvedt K, Lindberg H, Michelsen S, et al. (1996) Release of soluble tumor necrosis factor alpha receptors during and after cardiopulmonary bypass. Correlation with haemodynamic and clinical variables. Cytokine 8:944-948
22. Tei C (1995) New non-invasive index for combined systolic and diastolic ventricular function. J Cardiol 26:135-136
23. Tei C, Dujardin KS, Hodge DO, et al (1996) Doppler echocardiographic index of global right ventricular function. J Am Soc Echocardiogr 9:838-847
24. Tei C, Nishimura RA, Seward JB, Tajik AJ (1997) Noninvasive Doppler-derived myocardial performance index correlation with simultaneous measurements of cardiac catheterisation measurements. J Am Soc Echocardiogr 10:169-178
25. Wernovsky G, Wypij D, Jonas RA, et al (1995) Postoperative course and hemodynamic profile after the arterial switch operation in neonates and infants. A comparison of low-floow cardiopulmonary bypass and circulatory arrest. Circulation 92:2226-2235