Dose-incidence modeling: Consequences of linking quantal measures of response to depletion of critical tissue targets

Toxicological Sciences

Volumn 89, Issue 1, 2006, Pages 331-337

  Andersen, Melvin E ^a   Lutz, Roman W ^b   Liao, Kai H ^a   Lutz, Werner K ^c  

^a CIIT CENTERS FOR HEALTH RESEARCH   (United States)

^b ETH ZURICH   (Switzerland)

^c UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Biologically effective dose; Dose incidence relationship; Individual susceptibility; Logarithm; Pharmacodynamic modeling; Pharmacokinetic modeling

Indexed keywords

TOXIC SUBSTANCE;

ARTICLE; CONTROLLED STUDY; NONLINEAR SYSTEM; NORMAL DISTRIBUTION; RECEPTOR BINDING; STATISTICAL MODEL; TOXICOKINETICS;

ANIMALS; DISEASE SUSCEPTIBILITY; DOSE-RESPONSE RELATIONSHIP, DRUG; INCIDENCE; LOGISTIC MODELS; MODELS, BIOLOGICAL; RECEPTORS, DRUG; TOXICOLOGY; XENOBIOTICS;

EID: 29544450089     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfj024     Document Type: Article

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