Participation of tyrosine kinase and phospholipase Cγ in isradipine-induced proliferation of cultured human gingival fibroblasts

European Journal of Medical Research

Volumn 10, Issue 12, 2005, Pages 543-546

  Hattori, Toshimi ^a   Ara, T ^a   Wang, P ^a  

^a MATSUMOTO DENTAL UNIVERSITY   (Japan)

Author keywords

Gingival overgrowth; Isradipine; Phopholipase C ; Tyrosine kinase

Indexed keywords

1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 1H PYRROLE 2,5 DIONE; CALCIUM; HERBIMYCIN A; INOSITOL 1,4,5 TRISPHOSPHATE RECEPTOR; ISRADIPINE; PHOSPHOLIPASE C GAMMA; PROTEIN TYROSINE KINASE; XESTOSPONGIN C;

ARTICLE; CELL CULTURE; CELL GROWTH; CELL PROLIFERATION; CELL STRAIN; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; FIBROBLAST; GINGIVA OVERGROWTH; GROWTH INHIBITION; HUMAN; HUMAN CELL;

BENZOQUINONES; CALCIUM CHANNEL BLOCKERS; CELL PROLIFERATION; CELLS, CULTURED; DRUG INTERACTIONS; ENZYME INHIBITORS; ESTRENES; FIBROBLASTS; GINGIVA; HUMANS; ISRADIPINE; LACTAMS, MACROCYCLIC; MACROCYCLIC COMPOUNDS; OXAZOLES; PHOSPHOLIPASE C GAMMA; PROTEIN-TYROSINE KINASES; PYRROLIDINONES; QUINONES;

EID: 29444446809     PISSN: 09492321     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Amemiya T, Sasamura K, Mifune M, Kitamura I, Hirahashi J, Hayashi M, Saruta T (1999) Vascular endothelial growth factor activates MAP kinase and enhances collagen synthesis in human mesangial cells. Kidney Int 56: 2055-2063
2. Bansal R, Magge S, Winkler S (2003) Specific inhibitor of FGF receptor signaling, FGF-2-mediated effects on proliferation, differentiation, and MAPK activation are inhibited by PD173074 in oligodendrocyte-lineage cells. J Neurosci Res 4: 486-493
3. Becherer U, Moser T, Stuhmer W, Oheim M (2003) Calcium regulates exocytosis at the level of single vesicle. Nat Neurosci 6: 846-853
4. Brown RS, Beave WT, Bottomley WK (1991) On the mechanism of drug-induced gingival hyperplasia. J Oral Pthol Med 20: 201-209
5. 2+ accumulation in gingival fibroblasts in vitro. J Oral Pathol Med 18: 485-489
6. Calaf GM, Hei TK (2004) Ionizing radiation induces alterations in cellular proliferation and c-myc, c-jun and c-fos protein expression in breast epithelial cells. Int J Oncol 25: 1859-1866
7. Gille H, Strahl T, Shaw PE (1995) Activation of ternary complex factor Elk-1 by stress-activated protein kinases. Curr Biol 5: 1191-1200
8. Haendeler J, Yin G, Hojo Y, Saito Y, Melaragno M, Yan C, Sharma VK, Heller M, Aebersold R, Berk BC (2003) GIT1 mediates Src-dependent activation of phospholipase Cγ by angiotensin II and epidermal growth factor. J Biol Chem 278: 49936-49944
9. Hattori T (2003) Calcium influx by isradipine in Gin-1 cells. J Pharmacol Sci 91 (Suppl. 1): 224
10. Hattori T, Hirai K, Wang P, Fujimura S (2004) Proliferation of cultured human gingival fibroblasts caused by isradipine a dihydropyridine-derivative calcium antagonist. Eur J Med Res 9: 313-315
11. Hattori T, Maehashi H (1999) Rise in intracellular calcium concentration by propylene glycol in PC12 cells. Intern J Neurosci 99: 151-157
12. Hattori T, Wang P (2004) Inbibition by tranilast of nifedipine-induced proliferation of cultured human gingival fibroblasts. Eur J Pharmacol 498: 79-81
13. Hattori T, Wang P (2005) Rise in intracellular calcium concentration elicited by isradipine in Gin-1 cells. Pharmacol Res 51: 137-139
14. Johnson RB, Zebrowski EJ, Dai X (2000) Synergistic enhancement of collagenous protein synthesis by human gingival fibroblasts exposed to nifedipine and interleukin-1-beta in vitro. J Oral Pathol Med 29: 8-12
15. Kataoka M, Shimizu Y, Kunikiyo K, Asahara Y, Azuma H, Sawa T, Kido J, Nagata T (2001) Nifedipine induces gingival overgrowth in rats through a reduction in collagen phagocytosis by gingival fibroblasts. J Periodontol 72: 1078-1083
16. Kimball OP (1939) The treatment of epilepsy with sodium diphenyl hydantoinate. J Am Med Assoc 112: 1244-1245
17. Metcalfe JC, Moore JP, Smith GA, Hesketh TR (1986) Calcium and cell proliferation. Br Med Bull 42: 405-412
18. 2+ level in human gingival fibroblasts. Scand J Dent Res 99: 310-315
19. Moodie SA, Willumusen BM, Weber MJ, Wolfman A (1993) Complexes of Ras.GTP with Raf-1 and mitogen -activated protein kinase kinase. Sci 260: 1658-1661
20. Munaron L (2002) Calcium signaling and control of cell proliferation by tyrosine kinase receptors. Intern J Mol Med 10: 671-676
21. 2+ entry, A way to control cell proliferation. Curr Med Chem 11: 1533-1543
22. Rameh LE, Rhee SG, Spokes K, Kazlauskas A, Cantley LC, Cantle LG (1988) Phosphoinositide 3-kinase regulates phospholipase Cγ-mediated calcium signaling. J Biol Chem 273: 23750-23757
23. Smith MR, DeGudicibus SJ, Stacey DW (1986) Requirement for c-ras proteins during viral oncogene transformation. Nature 320: 540-543
24. Spolidorio LC, Spolidorio DM, Neves KA, Gonzaga HFS, Almeida OP (2002) Morphological evaluation of combined effects of cyclosporin and nifedipine on gingival overgrowth in rats. J Periodont Res 37: 192-195
25. Varnfield M, Botha SJ (2000) Drug-induced gingival hyperplasia - A review. SADJ 55:632-641