Does Cd36 gene play a key role in disturbed glucose and fatty acid metabolism in Prague hypertensive hypertriglyceridemic rats?

Physiological Research

Volumn 53, Issue 3, 2004, Pages 265-271

  Kadlecova M ^a   Cejka J ^a   Zicha, J ^a   Kuneš, Jaroslav ^a  

^a INSTITUTE OF PHYSIOLOGY   (Czech Republic)

Author keywords

Fatty acid; Hypertension; Insulin resistance; Metabolic syndrome; Oral glucose test

Indexed keywords

FATTY ACID; GLUCOSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD36 GENE; CHROMOSOME 4; CONTROLLED STUDY; CZECH REPUBLIC; FATTY ACID METABOLISM; GENE; GENE IDENTIFICATION; GENETIC DISORDER; GENOTYPE; GLUCOSE METABOLISM; HEREDITARY HYPERTENSION; HUMAN; HYPERTENSION; HYPERTRIGLYCERIDEMIA; INSULIN RESISTANCE; JAPAN; METABOLIC DISORDER; METABOLIC SYNDROME X; NONHUMAN; PATHOGENESIS; POLYMERASE CHAIN REACTION; QUANTITATIVE TRAIT LOCUS; RAT; STRAIN IDENTIFICATION; SYMPTOMATOLOGY;

ANIMALS; ANTIGENS, CD36; DISEASE MODELS, ANIMAL; FATTY ACIDS; GLUCOSE; HUMANS; HYPERTENSION; HYPERTRIGLYCERIDEMIA; INSULIN RESISTANCE; MALE; METABOLIC SYNDROME X; PHYLOGENY; POLYMORPHISM, GENETIC; RATS; RATS, INBRED LEW; RATS, INBRED WKY;

EID: 2942739218     PISSN: 08628408     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. AITMAN TJ, GLAZIER AM, WALLACE CA, COOPER LD, NORSWORTHY PJ, WAHID FN, AL-MAJALI KM, TREMBLING PM, MANN CJ, SHOULDERS CC, GRAF D, ST LEZIN E, KURTZ TW, KŘEN V, PRAVENEC M, IBRAHIMI A, ABUMRAD NA, STANTON LW, SCOTT J: Identification of Cd36 (FAT) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats. Nat Genet 21: 76-83, 1999.
2. DEVYNCK M-A, KUNEŠ J, LE QUAN SANG KH, ZICHA J: Membrane microviscosity and plasma triacylglycerols in the rat. Clin Sci 94: 79-85, 1998.
3. FERRANNINI E, BUZZIGOLI G, BANADONNA R, GIORICO MA, OLEGGINI M, GRAZIADEI L, PEDRINELLI R, BRANDI L, BEVILACQUA S: Insulin resistance in essential hypertension. N Engl J Med 317: 350-357, 1987.
4. GOTODA T, IIZUKA Y, KATO N, OSUGA J, BIHOREAU M-T, MURAKAMI T, YAMORI Y, SHIMANO H, ISHIBASHI S, YAMADA N: Absence of Cd36 mutation in the original spontaneously hypertensive rats with insulin resistance. Nat Genet 22: 226-228, 1999.
5. GREENWALT DE, SCHECK SH, RHINEHART-JONES T: Heart CD36 expression is increased in murine models of diabetes and in mice fed a high fat diet. J Clin Invest 96: 1382-1388, 1995.
6. HWANG I-S, HO H, HOFFMAN BB, REAVEN GM: Fructose-induced insulin resistance and hypertension in rats. Hypertension 10: 512-516, 1987.
7. KADLECOVÁ M, DOBEŠOVÁ Z, ZICHA J, KUNEŠ J: Nitric oxide synthase isoforms in Prague hypertriglyceridemic rats (HTG), gene polymorphisms, protein expression and participation in blood pressure regulation. Physiol Res 52: 51P, 2003.
8. KINCER JF, UITTENBOGAARD A, DRESSMAN J, GUERIN T, FEBBRAIO M, GUO L, SMART EJ: Hypercholesterolemia promotes a CD36-dependent and endothelial nitric-oxide synthase-mediated vascular dysfunction. J Biol Chem 277: 23525-23533, 2002.
9. KRISTEK F, URMANSKÁ M, KUNEŠ J, DOBEŠOVÁ Z: Geometry of conduit arteries of hypertriglyceridemic rats during ontogenic development. Physiol Res 52: 51P, 2003.
10. KUNEŠ J, DOBEŠOVÁ Z, ZICHA J: Altered balance of main vasopressor and vasodepressor systems in rats with genetic hypertension and hypertriglyceridaemia. Clin Sci 102: 269-277, 2002.
11. PRAVENEC M, LANDA V, ZÍDEK V, MUSILOVÁ A, KŘEN V, KAZDOVÁ L, AITMAN TJ, GLAZIER AM, IBRAHIMI A, ABUMRAD NA, QI N, WANG J-M, ST LEZIN EM, KURTZ TW: Transgenic rescue of defective Cd36 ameliorates insulin resistance in spontaneously hypertensive rats. Nat Genet 27: 156-158, 2001.
12. PRAVENEC M, LANDA V, ZÍDEK V, MUSILOVÁ A, KAZDOVÁ L, QI N, WANG J, ST LEZIN E, KURTZ TW: Transgenic expression of CD36 in the spontaneously hypertensive rat is associated with amelioration of metabolic disturbances but has no effect on hypertension. Physiol Res 52: 681-688, 2003.
13. REAVEN GM, CHANG H: Relationship between blood pressure, plasma insulin and triglyceride concentration, and insulin action in spontaneous hypertensive and Wistar-Kyoto rats. Am J Hypertens 4: 34-38, 1991.
14. REAVEN GM, HO H, HOFFMAN BB: Attenuation of fructose-induced hypertension in rats by exercise training. Hypertension 12: 129-132, 1988.
15. SHEN DC, SHIEH SM, FUH MM, WU DA, CHEN YD, REAVEN GM: Resistance to insulin-stimulated-glucose uptake in patients with hypertension. J Clin Endocrinol Metab 66: 580-583, 1988.
16. ŠTOLBA P, DOBEŠOVÁ Z, HUŠEK P, OPLTOVÁ H, ZICHA J, VRÁNA A, KUNEŠ J: The hypertriglyceridemic rat as a genetic model of hypertension and diabetes. Life Sci 51: 733-740, 1992.
17. TÖRÖK J, KRISTEK F, GEROVÁ M, KUNEŠ J, DOBEŠOVÁ Z: Endothelial function of conduit artery in newborn rats with hereditary hypertriglyceridemia. Physiol Res 52: 52P, 2003.
18. UENO T, TREMBLAY J, KUNEŠ J, ZICHA J, DOBEŠOVÁ Z, PAUSOVÁ Z, DENG AY, SUN Y-L, JACOB HJ, HAMET P: Resolving the composite trait of hypertension into its pharmacogenetic determinants by acute pharmacological modulation of blood pressure regulatory systems. J Mol Med 81: 51-60, 2003a.
19. UENO T, TREMBLAY J, KUNEŠ J, ZICHA J, DOBEŠOVÁ Z, PAUSOVÁ Z, DENG AY, SUN Y, JACOB HJ, HAMET P: Gender-specific genetic determinants of blood pressure and organ weight: pharmacogenetic approach. Physiol Res 52: 689-700, 2003b.
20. UENO T, TREMBLAY J, KUNEŠ J, ZICHA J, DOBEŠOVÁ Z, PAUSOVÁ Z, DENG AY, SUN YL, JACOB HJ, HAMET P: Rat model of familial combined hyperlipidemia as a result of comparative mapping. Physiol Genomics 17: 38-47, 2004.
21. VRÁNA A, KAZDOVÁ L: The hereditary hypertriglyceridemic nonobese rat: an experimental model of human hypertriglyceridemia. Transplant Proc 22: 2579, 1990.
22. ZICHA J, DOBEŠOVÁ Z, KUNEŠ J: Plasma triglycerides and red cell ion transport alterations in genetically hypertensive rats. Hypertension 30: 636-640, 1997.